Pulmonary Disease and Drug Kinetics

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

THE PLASMA PROTEINS

1960 • 934 citations

Digitalis Intoxication

1971 • 579 citations

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

1973 • 504 citations

Theophylline-Induced Seizures in Adults

1975 • 426 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

Clinical Experience With Theophylline

1976 • 271 citations

Clinical Pharmacokinetics of Digoxin

1977 • 255 citations

Plasma protein binding of basic drugs

1977 • 228 citations

Effect of smoking on theophylline disposition

1976 • 228 citations

Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion model

1974 • 214 citations

Altered Hepatic Blood Flow and Drug Disposition1

1976 • 209 citations

Pharmacokinetics of intravenous theophylline

1973 • 187 citations

A nomogram for digoxin therapy

1974 • 156 citations

α1-Acid Glycoprotein

1975 • 153 citations

Renal function in respiratory distress syndrome

1976 • 148 citations

Digoxin pharmacokinetics: Role of renal failure in dosage regimen design

1975 • 130 citations

Effect of Plasma Protein Binding on Elimination of Warfarin

1974 • 126 citations

Decreased theophylline half-life in cigarette smokers

1975 • 124 citations

Digitalis toxicity: Epidemiology and clinical use of serum concentration measurements

1975 • 123 citations

Frequent Toxicity from IV Aminophylline Infusions in Critically ILL Patients

2006 • 123 citations

Concepts in Biochemical Pharmacology

1975 • 122 citations

Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis.

1975 • 119 citations

The influence of heart failure, liver disease, and renal failure on the disposition of lidocaine in man

1971 • 114 citations

Lidocaine disposition kinetics in monkey and man; II. Effects of hemorrhage and sympathomimetic drug administration

1974 • 108 citations

Intravenous Aminophylline Dosage

1976 • 108 citations

Drug Disposition and Liver Disease

1975 • 102 citations

Increased plasma binding of quinidine after surgery: A preliminary report

1976 • 101 citations

Pharmacokinetics of Methicillin in Patients with Cystic Fibrosis

1977 • 93 citations

INTRAVENOUS CORTICOSTEROIDS IN TREATMENT OF ACUTE BRONCHIAL ASTHMA

1970 • 91 citations

Drug dosage in patients with renal disease

1974 • 87 citations

Ampicillin levels in sputum, serum, and saliva

1970 • 84 citations

Physiologically Based Pharmacokinetic Model for Digoxin Distribution and Elimination in the Rat

1977 • 66 citations

Physiologically Based Pharmacokinetic Model for Digoxin Disposition in Dogs and Its Preliminary Application to Humans

1977 • 63 citations

Effect of Binding to Plasma Proteins on the Distribution, Activity and Elimination of Drugs

1971 • 60 citations

Effect of Plasma Protein Binding of Drugs on Duration and Intensity of Pharmacological Activity

1976 • 59 citations

Absorption, Metabolism, and Excretion of the Ephedrines in Man II

1968 • 56 citations

Cor pulmonale (pulmonary heart disease): present-day status

1975 • 53 citations

The effect of arterial oxygen tension on antipyrine half‐time in plasma

1976 • 49 citations

A STUDY OF CORTISOL METABOLISM IN PATIENTS WITH CHRONIC ASTHMA

1967 • 48 citations

Theophylline Toxicity due to Impaired Theophylline Degradation^1,2

1974 • 47 citations

Effects of Low Oxygen and of Carbon Monoxide on the Renal Circulation in Unanesthetized Rabbits

1963 • 45 citations

Factors involved in digitalis sensitivity in chronic pulmonary insufficiency

1959 • 44 citations

The pharmacokinetics of ephedrine after oral dosage in asthmatics receiving acute and chronic treatment.

1976 • 38 citations

Role of blood flow in carbon monoxide- and hypoxic hypoxia-induced alterations in hexobarbital metabolism in rats.

1976 • 37 citations

Alteration of Rat Brain Catecholamine Metabolism During Exposure to Hypobaric Hypoxia

1972 • 37 citations

Protein binding of salicylate and quinidine in plasma from patients with renal failure, chronic liver disease and chronic respiratory insufficiency

1977 • 35 citations

Loading and Maintenance Doses of Digoxin in Patients with Normal Renal Function and Those with Severely Impaired Renal Function

1974 • 33 citations

Role of Hypoxia in Digitalis Toxicity

1968 • 33 citations

Effect of phenobarbital administration on the oxygen requirement for hexobarbital metabolism in the isolated, perfused rat liver and in the intact rat

1970 • 33 citations

Effects of Gestational Age, Birth Weight, and Hypoxemia on Pharmacokinetics of Amikacin in Serum of Infants

1977 • 33 citations

Atrioventricular Conduction System in Left Bundle-Branch Block with Normal QRS Axis

1972 • 32 citations

Metabolism of procainamide in patients with chronic heart failure, chronic respiratory failure and chronic renal failure

1978 • 27 citations

Urinary Excretion of Ephedrine in Man without pH Control following Oral Administration of Three Commercial Ephedrine Sulfate Preparations

1971 • 25 citations

Pharmacokinetic Analysis of Renal Handling of Sulfamethizole

1976 • 24 citations

Digitalis and cor pulmonale.

1965 • 23 citations

Oxygenation during inhibition of drug metabolism by carbon monoxide or hypoxic hypoxia.

1973 • 22 citations

Pharmacology of some oral penicillins in the newborn infant.

1975 • 20 citations

Altitude-induced alterations in drug action and metabolism

1968 • 20 citations

Half-life of tolbutamide in patients with chronic respiratory failure

1971 • 19 citations

Increased clearance of tolbutamide from the blood of asthmatic patients.

1971 • 16 citations

Digitalis in Pulmonary Heart Disease (Cor Pulmonale)1

1977 • 15 citations

Digitalis Toxicity in Chronic Cor Pulmonale

1956 • 15 citations

Transient cardiac arrhythmias after single daily maintenance doses of digoxin

1976 • 15 citations

Effect of alkalosis on ouabain toxicity in the dog.

1973 • 12 citations

Chronic pulmonary disease and antipyrine disposition.

1978 • 12 citations

Erratic and incomplete absorption of furosemide in congestive heart failure

1976 • 10 citations

Drug metabolism and pharmacologic action in mice exposed to reduced barometric pressure

1970 • 8 citations

The use of the potassium-43 myocardial scan in evaluating myocardial revascularization

1973 • 6 citations

Effect of chronic hypoxia on ouabain-induced arrhythmias

1973 • 5 citations

Protein-binding and metabolic clearance of cortisol in asthmatic patients.

1974 • 4 citations

Indoor Air Pollution by Mercury

1973 • 3 citations