The effects of age and liver disease on the disposition and elimination of diazepam in adult man.

Clearance concepts in pharmacokinetics

1973 • 741 citations

Lidocaine Pharmacokinetics in Advanced Heart Failure, Liver Disease, and Renal Failure in Humans

1973 • 504 citations

Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single Compartment

1968 • 383 citations

Effect of Age and Sex on Human Drug Metabolism

1971 • 379 citations

Determination of drug metabolizing enzymes in needle biopsies of human liver

1972 • 332 citations

Variation in the activity of liver microsomal drug-metabolizing enzymes in rats in relation to the age

1964 • 258 citations

Pharmacokinetic Profile of Diazepam in Man following Single Intravenous and Oral and Chronic Oral Administrations

1973 • 257 citations

Pharmacological and clinical studies on Valium (T.M.) a new psychotherapeutic agent of the benzodiazepine class.

1961 • 242 citations

Metabolism of diazepam in rat, dog, and man.

1965 • 229 citations

The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat.

1973 • 205 citations

Blood Level Distribution Patterns of Diazepam and its Major Metabolite in Man

1966 • 202 citations

PHENYLBUTAZONE AND ISONIAZID METABOLISM IN PATIENTS WITH LIVER DISEASE IN RELATION TO PREVIOUS DRUG THERAPY

1968 • 196 citations

Clinical Depression of the Central Nervous System Due to Diazepam and Chlordiazepoxide in Relation to Cigarette Smoking and Age

1973 • 189 citations

Determinants of serum antipyrine half-lives in patients with liver disease

1973 • 178 citations

Concept of a Volume of Distribution and Possible Errors in Evaluation of This Parameter

1968 • 164 citations

The effect of cirrhosis on the disposition and elimination of meperidine in man

1974 • 163 citations

THE EFFECT OF INCREASING AGE ON THE DISTRIBUTION OF PERIPHERAL BLOOD FLOW IN MAN

1965 • 163 citations

PERSISTENCE OF ANTIBIOTICS IN BLOOD OF PATIENTS WITH ACUTE RENAL FAILURE. II. CHLORAMPHENICOL AND ITS METABOLIC PRODUCTS IN THE BLOOD OF PATIENTS WITH SEVERE RENAL DISEASE OR HEPATIC CIRRHOSIS*†

1959 • 162 citations

Determination medazepam (Nobrium), diazepam (Valium), and their major biotransformation products in blood and urine by electron capture gas-liquid chromatography

1970 • 158 citations

Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease

1972 • 119 citations

Diazepam elimination in premature and full term infants, and children

1973 • 116 citations

Determination of bioavailability of diazepam in various formulations from steady state plasma concentration data

1972 • 101 citations

Diazepam metabolism during chronic medication

1973 • 98 citations

Effects of Change in Elimination on Various Parameters of the Two-Compartment Open Model

1972 • 97 citations

METABOLISM OF DRUGS IN OLD RATS (II) METABOLISM IN VIVO AND EFFECT OF DRUGS IN OLD RATS

1968 • 91 citations

Metabolism of amylobarbitone in patients with chronic liver disease

1972 • 90 citations

Pharmacodynamics of Carbenicillin in Hepatic and Renal Failure

1970 • 89 citations

Pharmacokinetics of Diazepam in Dogs, Mice and Humans

1971 • 89 citations

Species difference in diazepam metabolism and anticonvulsant effect

1968 • 77 citations

PHARMACOLOGIC ASPECTS OF AGING: A SURVEY OF THE EFFECT OF INCREASING AGE ON DRUG ACTIVITY IN ADULTS

1964 • 60 citations

Disappearance Rate of Tolbutamide in Normal Subjects and in Diabetes Mellitus, Liver Cirrhosis, and Renal Disease

1963 • 59 citations

Hepatic Hemodynamics During Viral Hepatitis in Man

1966 • 51 citations

Further studies on species difference in diazepam metabolism

1970 • 49 citations

The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver.

1973 • 48 citations

Metabolism of diazepam in vitro

1968 • 43 citations

The metabolism of diazepam by liver microsomal enzymes of rats and mice

1969 • 43 citations

Rate of Aminopyrine Disappearance from Plasma in Young and Aged Humans

1972 • 40 citations

Metabolism of diazepam in isolated perfused liver of rat and mouse

1968 • 27 citations

Clinical and Electroencephalographic Assessment of Diazepam in Liver Disease

1971 • 23 citations

Relationship between plasma or serum drug concentration and amount of drug in the body at steady state upon multiple dosing

1973 • 23 citations

Correlation between the duration of the anticonvulsant activity of diazepam and its physiological disposition in mice

1970 • 21 citations

PHARMACOKINETICS OF DISTRIBUTION AND METABOLISM OF ATARACTIC DRUGS AND AN EVALUATION OF THE SITE OF ANTIANXIETY ACTIVITY*

1971 • 20 citations

Microsomal Pentobarbital Hydroxylase Activity in Acute Viral Hepatitis

1972 • 20 citations

Time Integral of Drug Concentration in the Central (Plasma) Compartment

1970 • 17 citations

Effect of Experimental Hepatic Injury on the Clearance of Phenobarbital and Paraldehyde

1973 • 16 citations

Pharmacodynamic consequences of aging and their implications in the treatment of the elderly patient.

1967 • 6 citations

Influence of acute and chronic nicotine administration on EEG reactivity to drugs in rabbits. 2. Psychoactive agents.

1970 • 3 citations

Disappearance Rate of Tolbutamide in Normal Subjects and in Diabetes Mellitus, Liver Cirrhosis, and Renal Disease

1963 • 2 citations