Mitochondrial nitric oxide synthase

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Nitric oxide synthases: structure, function and inhibition

2001 • 3,508 citations

Arginine metabolism: nitric oxide and beyond

1998 • 2,697 citations

Nitric oxide synthases: structure, function and inhibition

2001 • 2,499 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

The mitochondrial permeability transition pore and its role in cell death

1999 • 2,326 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide

2003 • 1,199 citations

Dynamic activation of endothelial nitric oxide synthase by Hsp90

1998 • 1,016 citations

Subcellular Distribution of Superoxide Dismutases (SOD) in Rat Liver

2001 • 971 citations

Superoxide Dismutase

1973 • 887 citations

Methods in nitric oxide research

1996 • 826 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

Methods in Nitric Oxide Research

1997 • 726 citations

The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O ₂

2000 • 696 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Production of Nitric Oxide by Mitochondria

1998 • 573 citations

Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen.

2001 • 497 citations

Endothelial-Type Nitric Oxide Synthase (ec-NOS) in Skeletal Muscle Fibers: Mitochondrial Relationships

1995 • 379 citations

Peroxisome Proliferator-Activated Receptor γ-Dependent Repression of the Inducible Nitric Oxide Synthase Gene

2000 • 377 citations

Nitric oxide inhibition of mitochondrial respiration and its role in cell death

2002 • 372 citations

The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties

2000 • 358 citations

Biochemistry of Mitochondrial Nitric-oxide Synthase

2002 • 349 citations

Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection

2001 • 339 citations

Mitochondrial Nitric-oxide Synthase Stimulation Causes Cytochrome c Release from Isolated Mitochondria

1999 • 333 citations

Purification and Characterization of a Nitric-oxide Synthase from Rat Liver Mitochondria

1998 • 329 citations

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease

2000 • 326 citations

Control of mitochondrial and cellular respiration by oxygen

1995 • 303 citations

Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species 1,2 1Guest Editor: Harry Ischiropoulos 2This article is part of a series of reviews on “Reactive Nitrogen Species, Tyrosine Nitration and Cell Signaling.” The full list of papers may be found on the homepage of the journal.

2002 • 301 citations

Nitric Oxide and Peroxynitrite Interactions with Mitochondria

2002 • 287 citations

Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung

1996 • 261 citations

Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?

1996 • 244 citations

Protein Import Into Mitochondria

2001 • 224 citations

Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism

1998 • 221 citations

High-throughput profiling of the mitochondrial proteome using affinity fractionation and automation

2000 • 219 citations

Cytochrome oxidase.

1969 • 218 citations

Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase

2001 • 211 citations

Localization of Nitric Oxide Synthase in Human Skeletal Muscle

1996 • 210 citations

Ca2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase.

1992 • 210 citations

Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver

1995 • 204 citations

Interfering with Nitric Oxide Measurements

2002 • 190 citations

Melatonin counteracts lipopolysaccharide‐induced expression and activity of mitochondrial nitric oxide synthase in rats

2003 • 184 citations

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

2000 • 177 citations

Endogenous Endothelial Nitric Oxide Synthase–Derived Nitric Oxide Is a Physiological Regulator of Myocardial Oxygen Consumption

1999 • 173 citations

The role of mitochondrial nitric oxide synthase in inflammation and septic shock

2002 • 169 citations

High throughput two-dimensional blue-native electrophoresis: A tool for functional proteomics of mitochondria and signaling complexes

2002 • 163 citations

Nitric Oxide and Cytochrome c Oxidase: Mechanisms of Inhibition and NO Degradation

2000 • 161 citations

Determination of Km for oxygen of nitric oxide synthase isoforms.

1996 • 149 citations

Mitochondrial nitric oxide synthase is not eNOS, nNOS or iNOS

2003 • 144 citations

Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells

2004 • 143 citations

Characterization and function of mitochondrial nitric-oxide synthase

2003 • 141 citations

Mitochondrial Ca<sup>2+</sup> Transport and the Role of Intramitochondrial Ca<sup>2+</sup> in the Regulation of Energy Metabolism

1993 • 141 citations

Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia

2001 • 134 citations

Mitochondrial respiration at low levels of oxygen and cytochrome c

2002 • 133 citations

Subcellular localization and characterization of nitric oxide synthase(s) in endothelial cells: physiological implications

1994 • 133 citations

Direct Evidence of Nitric Oxide Presence within Mitochondria

2000 • 127 citations

Kinetics of the inhibition of mitochondrial respiration by NO

1997 • 125 citations

The regulation of carbamoyl phosphate synthase activity in rat liver mitochondria

1976 • 118 citations

Mitochondria recycle nitrite back to the bioregulator nitric monoxide.

2000 • 116 citations

Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.

1979 • 112 citations

Nitric oxide synthase activity in hyperthyroid and hypothyroid rats

2002 • 105 citations

Mitochondrial Uptake and Recycling of Ascorbic Acid

2001 • 105 citations

Classical and Slow-Binding Inhibitors of Human Type II Arginase

2001 • 103 citations

The Modulation of Mitochondrial Nitric-oxide Synthase Activity in Rat Brain Development

2002 • 103 citations

Nitric oxide and cytochrome oxidase: reaction mechanisms from the enzyme to the cell

2003 • 101 citations

Pharmacological regulation of mitochondrial nitric oxide synthase

2002 • 101 citations

Oxygen dependence of mitochondrial nitric oxide synthase activity

2003 • 94 citations

Hyperglycemic switch from mitochondrial nitric oxide to superoxide production in endothelial cells

2002 • 93 citations

Nitric oxide production by endothelial cells: Comparison of three methods of quantification

1997 • 90 citations

Measurement of the intramitochondrial volume in hepatocytes without cell disruption and its elevation by hormones and valinomycin

1983 • 89 citations

The Nitric Oxide Producing Reactions of Hydroxyurea

2003 • 87 citations

Nitric oxide synthase in porcine heart mitochondria: evidence for low physiological activity

2001 • 85 citations

Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons

1996 • 84 citations

REACTIONS OF CYTOCHROME OXIDASE

1955 • 81 citations

Metabolism of S-nitrosoglutathione in intact mitochondria

2001 • 78 citations

Analysis of the pathways of nitric oxide utilization in mitochondria

2000 • 75 citations

hsp90 Is Required for Heme Binding and Activation of Apo-Neuronal Nitric-oxide Synthase

2002 • 73 citations

Differing roles of mitochondrial nitric oxide synthase in cardiomyocytes and urothelial cells

2004 • 73 citations

Modulation of liver mitochondrial NOS is implicated in thyroid-dependent regulation of O₂ uptake

2001 • 72 citations

Histochemical localization of nadph-dependent diaphorase (nitric oxide synthase) activity in vascular endothelial cells in the rat brain

1993 • 72 citations

Protective role of nitric oxide synthase against ischemia-reperfusion injury in guinea pig myocardial mitochondria

1999 • 71 citations

Near-neighbor relations of the subunits of cytochrome c oxidase

1977 • 68 citations

Development of Enzymes of Energy Metabolism in the Neonatal Mammalian Brain

1993 • 65 citations

Mitochondrial Nitric Oxide Synthase Regulates Mitochondrial Matrix pH

1999 • 65 citations

Sequential NO Production by Mitochondria and Endoplasmic Reticulum during Induced Apoptosis

2002 • 64 citations

Electrochemical methods for detection of nitric oxide

1996 • 61 citations

Signaling Complex Organization by PDZ Domain Proteins

2002 • 59 citations

Long-term angiotensin II inhibition increases mitochondrial nitric oxide synthase and not antioxidant enzyme activities in rat heart

2002 • 55 citations

Regulation of the urea cycle enzyme genes in nitric oxide synthesis

1998 • 51 citations

Metabolism of S-nitrosoglutathione in intact mitochondria

2001 • 42 citations

Modulation of mitochondrial nitric oxide synthase and energy expenditure in rats during cold acclimation

2003 • 41 citations

Arginine, mitochondrial arginase, and the control of carbamyl phosphate synthesis

1981 • 40 citations

Mitochondrial Nitric Oxide Localization in H9c2 Cells Revealed by Confocal Microscopy

2002 • 37 citations

Tetrahydrobiopterin, a Cofactor in Mitochondrial Electron Transfer. Effect of Tetrahydropterins on Intact Rat-Liver Mitochondria

1972 • 36 citations

Arginase Activity is Inhibited by l -NAME, both In Vitro and In Vivo

2002 • 36 citations

Measurement of mitochondrial respiratory thresholds and the control of respiration by nitric oxide

2002 • 33 citations

Nitric oxide, a physiological modulator of mitochondrial function.

1996 • 31 citations

Reversible Inhibition of Cytochrome c Oxidase by Peroxynitrite Proceeds through Ascorbate-dependent Generation of Nitric Oxide

2003 • 27 citations

Cytosolic and Membrane-Bound Nitric Oxide Synthase.

1991 • 27 citations

Stimulatory effect of arginine on acetylglutamate synthesis in isolated mitochondria of mouse and rat liver

1985 • 20 citations

Tetrahydrobiopterin, a Cofactor in Mitochondrial Electron Transfer

1972 • 20 citations

Mitochondrial nitric oxide inhibits ATP synthesis Effect of free calcium in rat heart

2003 • 20 citations

Characterization of mitochondrial nitric oxide synthase

2002 • 16 citations

Mitochondrial Control of Inducible Nitric Oxide Production in Stimulated RAW 264.7 Macrophages

2001 • 16 citations

Triiodothyronine Administration Affects Urea Synthesis in Rats

1991 • 15 citations

Changes in Liver Concentration of N-Acetylglutamate and Ornithine are Involved in Regulating Urea Synthesis in Rats Treated with Thyroid Hormone

1992 • 14 citations

Antipain inhibits thyroxine-induced synthesis of carbamyl phosphate synthetase I in tadpole liver.

1978 • 13 citations

The mechanism of Ca2+ stimulation of citrulline and N-acetylglutamate synthesis by mitochondria

1990 • 11 citations

Cytosolic and Membrane-Bound Nitric Oxide Synthase

1991 • 5 citations

[25] Fluorescent imaging of mitochondrial nitric oxide in living cells

2002 • 4 citations