Heparan Sulfate Proteoglycans (HSPGs) Modulate BMP2 Osteogenic Bioactivity in C2C12 Cells

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

1994 • 1,442 citations

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

2003 • 1,115 citations

Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome

1996 • 767 citations

Human Bone Morphogenetic Protein 2 Contains a Heparin‐Binding Site which Modifies Its Biological Activity

1996 • 555 citations

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling

1999 • 474 citations

Developmental Regulation of Neural Response to FGF-1 and FGF-2 by Heparan Sulfate Proteoglycan

1993 • 420 citations

Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions

2000 • 361 citations

Overexpression of an Osteogenic Morphogen in Fibrodysplasia Ossificans Progressiva

1996 • 360 citations

Heparan sulfate proteoglycan as a plasma membrane carrier

2003 • 305 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

Different Heparan Sulfate Proteoglycans Serve asCellular Receptors for HumanPapillomaviruses

2003 • 272 citations

Sulfated Polysaccharides Enhance the Biological Activities of Bone Morphogenetic Proteins

2003 • 262 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

Dimethylmethylene blue-based spectrophotometry of glycosaminoglycans in untreated urine: a rapid screening procedure for mucopolysaccharidoses.

1989 • 218 citations

Opposing Activities of Dally-like Glypican at High and Low Levels of Wingless Morphogen Activity

2004 • 213 citations

Heparan Sulfate Proteoglycans Retain Noggin at the Cell Surface

2002 • 209 citations

Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila

1997 • 196 citations

Domain-specific Modification of Heparan Sulfate by Qsulf1 Modulates the Binding of the Bone Morphogenetic Protein Antagonist Noggin

2004 • 190 citations

Hereditary multiple exostoses and heparan sulfate polymerization

2002 • 185 citations

Glypican-3 Modulates BMP- and FGF-Mediated Effects during Renal Branching Morphogenesis

2001 • 179 citations

Action Range of BMP Is Defined by Its N-Terminal Basic Amino Acid Core

2002 • 175 citations

Spatial Regulation of Wingless Morphogen Distribution and Signaling by Dally-like Protein

2004 • 164 citations

IN VIVO SOMATIC CELL GENE TRANSFER OF AN ENGINEERED NOGGIN MUTEIN PREVENTS BMP4-INDUCED HETEROTOPIC OSSIFICATION

2003 • 144 citations

Heparan sulfate is required for bone morphogenetic protein-7 signaling

2003 • 117 citations

PARESIS OF A BONE MORPHOGENETIC PROTEIN-ANTAGONIST RESPONSE IN A GENETIC DISORDER OF HETEROTOPIC SKELETOGENESIS

2003 • 88 citations

A Kinase Domain-truncated Type I Receptor Blocks Bone Morphogenetic Protein-2-induced Signal Transduction in C2C12 Myoblasts

1997 • 82 citations

Endocytosis and Signaling

2003 • 76 citations

Cell surface heparan sulfate proteoglycans and lipoprotein metabolism

1999 • 76 citations

Genetic dissection of proteoglycan function in Drosophila and C. elegans

2001 • 71 citations

Cell-surface Heparan Sulfate Proteoglycans Potentiate Chordin Antagonism of Bone Morphogenetic Protein Signaling and Are Necessary for Cellular Uptake of Chordin

2004 • 71 citations

Thromboprophylaxis Using a Low Molecular Weight Heparin Delays Fracture Repair

2000 • 68 citations

Low doses and high doses of heparin have different effects on osteoblast‐like Saos‐2 cells in vitro

2004 • 60 citations

In Vivo Involvement of Heparan Sulfate Proteoglycan in the Bioavailability, Internalization, and Catabolism of Exogenous Basic Fibroblast Growth Factor

1999 • 49 citations

Bmps: multifunctional regulators of mammalian embryonic development.

1996 • 28 citations

Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes

2001 • 27 citations

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