Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Resveratrol improves health and survival of mice on a high-calorie diet

2006 • 4,102 citations

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

2006 • 3,767 citations

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

2009 • 3,397 citations

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

2006 • 2,113 citations

Stereological Methods. Practical methods for biological morphometry

1979 • 2,038 citations

Practical methods for biological morphometry

1979 • 1,498 citations

Antioxidants prevent health-promoting effects of physical exercise in humans

2009 • 1,466 citations

mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex

2007 • 1,345 citations

Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide

2003 • 1,199 citations

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

2008 • 1,122 citations

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

2005 • 1,075 citations

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

2009 • 1,068 citations

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

2002 • 1,051 citations

Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals

2006 • 925 citations

Elevated blood pressures in mice lacking endothelial nitric oxide synthase

1996 • 888 citations

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

1994 • 785 citations

Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

2007 • 761 citations

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

2008 • 614 citations

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

2006 • 603 citations

Tissue-specific regulation of SIRT1 by calorie restriction

2008 • 546 citations

4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila

2009 • 523 citations

Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

2008 • 503 citations

Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals

2004 • 485 citations

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

2008 • 468 citations

Reduced TOR Signaling Extends Chronological Life Span via Increased Respiration and Upregulation of Mitochondrial Gene Expression

2007 • 421 citations

Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels

2009 • 394 citations

Exogenous amino acids stimulate net muscle protein synthesis in the elderly.

1998 • 393 citations

Transgenic Mice with a Reduced Core Body Temperature Have an Increased Life Span

2006 • 373 citations

Amino acid regulation of TOR complex 1

2008 • 372 citations

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

2007 • 371 citations

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

2009 • 345 citations

Endocrine regulation of ageing

2007 • 345 citations

Mitochondrial biogenesis and healthy aging

2008 • 344 citations

The TOR pathway comes of age

2009 • 333 citations

Metabolic reprogramming, caloric restriction and aging

2009 • 279 citations

Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women

2009 • 268 citations

Nutritional Supplements with Oral Amino Acid Mixtures Increases Whole-Body Lean Mass and Insulin Sensitivity in Elderly Subjects with Sarcopenia

2008 • 226 citations

Autophagy and amino acid homeostasis are required for chronological longevity in Saccharomyces cerevisiae

2009 • 224 citations

Restoration of Human Dystrophin Following Transplantation of Exon-Skipping-Engineered DMD Patient Stem Cells into Dystrophic Mice

2007 • 222 citations

Mitochondrial Oxygen Consumption and Reactive Oxygen Species Production are Independently Modulated: Implications for Aging Studies

2007 • 212 citations

Development of Calorie Restriction Mimetics as a Prolongevity Strategy

2004 • 199 citations

Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction

2009 • 176 citations

Nutritional and Anti-Inflammatory Interventions in Chronic Heart Failure

2008 • 172 citations

Dietary Energy Restriction Modulates the Activity of AMP-Activated Protein Kinase, Akt, and Mammalian Target of Rapamycin in Mammary Carcinomas, Mammary Gland, and Liver

2008 • 169 citations

AMPKα1 regulates the antioxidant status of vascular endothelial cells

2009 • 169 citations

Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice

2003 • 163 citations

Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes

2008 • 142 citations

Pathology of Aging B6;129 Mice

2001 • 137 citations

Exercise Increases Average Longevity of Female Rats Despite Increased Food Intake and No Growth Retardation

1993 • 130 citations

Nitric Oxide in Physiologic Concentrations Targets the Translational Machinery to Increase the Proliferation of Human Breast Cancer Cells: Involvement of Mammalian Target of Rapamycin/eIF4E Pathway

2007 • 130 citations

Nitric Oxide-Dependent Mitochondrial Biogenesis Generates Ca2+ Signaling Profile of Lupus T Cells

2004 • 124 citations

Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms

2009 • 122 citations

In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function

2008 • 110 citations

Transcriptional response to aging and caloric restriction in heart and adipose tissue

2007 • 99 citations

Improvement of Blood Glucose Control and Insulin Sensitivity During a Long-Term (60 Weeks) Randomized Study with Amino Acid Dietary Supplements in Elderly Subjects with Type 2 Diabetes Mellitus

2008 • 82 citations

Premature death and age-related cardiac dysfunction in male eNOS-knockout mice

2004 • 80 citations

Skeletal muscle subsarcolemmal mitochondrial dysfunction in high-fat fed rats exhibiting impaired glucose homeostasis

2007 • 71 citations

Effect of exercise training on whole-body insulin sensitivity and responsiveness

1984 • 68 citations

Effects of voluntary wheel running and amino acid supplementation on skeletal muscle of mice

2004 • 51 citations

Age-related changes in the motricity of the inbred mice strains 129/sv and C57BL/6j

2006 • 44 citations

Oral Amino Acid Supplementation Counteracts Age-Induced Sarcopenia in Elderly Rats

2008 • 38 citations