Caloric restriction-induced life extension of rats and mice: A critique of proposed mechanisms

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions*

1984 • 3,073 citations

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

1999 • 2,199 citations

The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size

1935 • 2,189 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

2004 • 1,877 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

2005 • 1,272 citations

Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway

2004 • 1,229 citations

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

2002 • 1,051 citations

Overview of caloric restriction and ageing

2005 • 1,040 citations

Influence of TOR kinase on lifespan in C. elegans

2003 • 1,017 citations

Hormesis defined

2007 • 1,010 citations

Extension of chronological life span in yeast by decreased TOR pathway signaling

2006 • 939 citations

The genetics of caloric restriction in Caenorhabditis elegans

1998 • 918 citations

Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

2004 • 874 citations

Handbook of the Biology of Aging

1978 • 871 citations

Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

2006 • 856 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance

2005 • 696 citations

The Rate of Living.

1928 • 686 citations

Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

2006 • 664 citations

Longevity, senescence, and the genome

1992 • 609 citations

The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

2006 • 603 citations

Nutritional Influences on Aging of Fischer 344 Rats: I. Physical, Metabolic, and Longevity Characteristics

1985 • 587 citations

Life Span Study of SPF Fischer 344 Male Rats Fed AdLibitum or Restricted Diets: Longevity, Growth, Lean Body Mass and Disease

1982 • 573 citations

Effects of diet restriction on life span and age-related changes in dogs

2002 • 569 citations

Low methionine ingestion by rats extends life span.

1993 • 547 citations

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

2007 • 534 citations

Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

2007 • 531 citations

Aging and oxidative stress: Modulation by dietary restriction

1996 • 450 citations

Extending the lifespan of long-lived mice

2001 • 425 citations

Handbook of the Biology of Aging

2005 • 413 citations

Dietary restriction in Drosophila

2005 • 350 citations

Retarded Growth, Life Span, Ultimate Body Size and Age Changes in the Albino Rat after Feeding Diets Restricted in Calories

1939 • 347 citations

Nutrition and Longevity in the Rat

1960 • 319 citations

Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction

2006 • 311 citations

The Inflammation Hypothesis of Aging

2001 • 307 citations

Dietary Restriction Alters Characteristics of Glucose Fuel Use

1992 • 304 citations

How to Live Long and Prosper: Autophagy, Mitochondria, and Aging

2008 • 265 citations

Temporal linkage between the phenotypic and genomic responses to caloric restriction

2004 • 261 citations

Assessment of the Role of the Glucocorticoid System in Aging Processes and in the Action of Food Restriction

1991 • 245 citations

Action of food restriction in delaying the aging process.

1982 • 243 citations

Influence of Age and Long-term Dietary Restriction on Plasma Insulin-like Growth Factor-1 (IGF-1), IGF-1 Gene Expression, and IGF-1 Binding Proteins

1991 • 237 citations

Caloric Restriction in Primates and Relevance to Humans

2001 • 227 citations

Pleiotropic Effects of Growth Hormone and Insulin-like Growth Factor (IGF)-1 on Biological Aging: Inferences From Moderate Caloric-Restricted Animals

1999 • 220 citations

Changes in Adipose Mass and Cellularity Through the Adult Life of Rats Fed Ad Libitum or a Life-Prolonging Restricted Diet

1980 • 203 citations

Why Do Life Spans Differ? Partitioning Mean Longevity Differences in Terms of Age-Specific Mortality Parameters

2000 • 203 citations

Energy metabolism and aging: a lifelong study of Fischer 344 rats

1992 • 202 citations

Visceral adipose tissue modulates mammalian longevity

2008 • 199 citations

Hormesis as a biological hypothesis.

1998 • 195 citations

Effects of food restriction on aging: separation of food intake and adiposity.

1984 • 191 citations

Onset of puberty and duration of fertility in rats fed a restricted diet

1979 • 183 citations

Hormesis and the Antiaging Action of Dietary Restriction

1998 • 166 citations

Modulation of redox-sensitive transcription factors by calorie restriction during aging

2002 • 164 citations

Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein

1989 • 154 citations

Differential Effects of Intermittent Feeding and Voluntary Exercise on Body Weight and Lifespan in Adult Rats

1983 • 153 citations

THE EXPERIMENTAL MANIPULATION OF AGEING BY DIET

1986 • 152 citations

Influence of the Restriction of Individual Dietary Components on Longevity And Age-Related Disease of Fischer Rats: The Fat Component and the Mineral Component

1988 • 132 citations

Energy Restriction Lowers the Expression of Genes Linked to Inflammation, the Cytoskeleton, the Extracellular Matrix, and Angiogenesis in Mouse Adipose Tissue

2006 • 130 citations

Caloric Restriction and Aging: Controversial Issues

2006 • 122 citations

Caloric restriction and genomic stability

2007 • 118 citations

Caloric Restriction: A Key to Understanding and Modulating Aging

2013 • 112 citations

Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice.

1999 • 110 citations

Long-term calorie restriction reduces proton leak and hydrogen peroxide production in liver mitochondria

2004 • 109 citations

Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition

2005 • 107 citations

Hyperadrenocorticism, Attenuated Inflammation, and the Life-Prolonging Action of Food Restriction in Mice

1995 • 105 citations

Aging, anti-aging, and hormesis

2004 • 105 citations

Peroxisome Proliferator-Activated Receptor Coactivator 1 in Caloric Restriction and Other Models of Longevity

2005 • 103 citations

Sir2 and calorie restriction in yeast: A skeptical perspective

2007 • 101 citations

Survival Characteristics and Age-Adjusted Disease Incidences in C57BL/6 Mice Fed a Commonly Used Cereal-Based Diet Modulated by Dietary Restriction

2002 • 98 citations

Effect of caloric restriction on the expression of heat shock protein 70 and the activation of heat shock transcription factor 1

1996 • 95 citations

Adipocytokines and the Regulation of Lipid Metabolism in Growth Hormone Transgenic and Calorie-Restricted Mice

2007 • 91 citations

Physical activity as a factor in the action of dietary restriction on aging: Effects in Fischer 344 rats

1997 • 90 citations

Protein, calories and life expectancy.

1959 • 88 citations

Long-term food restriction depresses serum thyroid hormone concentrations in the rat

1990 • 86 citations

Applying hormesis in aging research and therapy

2001 • 85 citations

The Role of Hormesis in Life Extension by Dietary Restriction

2006 • 85 citations

Energy Restriction Reduces Metabolic Rate in Adult Male Fisher-344 Rats

1993 • 76 citations

Histology and survival in age-delayed low-tryptophan-fed rats

1988 • 74 citations

Effects of Dietary Calorie Restriction or Exercise on the PI3K and Ras Signaling Pathways in the Skin of Mice

2007 • 70 citations

Metabolic Reprogramming in Dietary Restriction

2006 • 67 citations

A Unifying Hypothesis To Explain the Retardation of Aging and Tumorigenesis by Caloric Restriction

1995 • 64 citations

A Physiological Dose of Triiodothyronine Normalizes Cardiac Myosin Adenosine Triphosphatase Activity and Changes Myosin Isoenzyme Distribution in Semistarved Rats*

1983 • 56 citations

A tumor preventive effect of dietary restriction is antagonized by a high housing temperature through deprivation of torpor

1996 • 54 citations

Moderate caloric restriction increases type 1 IGF receptors and protein synthesis in aging rats

1993 • 54 citations

Effect of Aging and Anti-Aging Caloric Restriction on the Endocrine Regulation of Rat Liver Autophagy

2008 • 49 citations

In vivo DNA synthesis in the dietary restricted long-lived rat

1985 • 40 citations

Brief Dietary Restriction Increases Skeletal Muscle Glucose Transport in Old Fischer 344 Rats

1996 • 35 citations

Secrets of the lac Operon

2006 • 34 citations

Dietary Restriction in the Nematode Caenorhabditis elegans

2006 • 33 citations

Hepatic Gene Expression Profile of Lipid Metabolism in Rats: Impact of Caloric Restriction and Growth Hormone/Insulin-Like Growth Factor-1 Suppression

2006 • 29 citations

Hormesis - Implications for risk assessment caloric intake (body weight) as an exemplar

1998 • 21 citations

Mechanisms of Dietary Restriction in Aging and Disease

2006 • 21 citations

Mechanisms of Dietary Restriction in Aging and Disease

2006 • 19 citations

The role of dna damage in cellular aging: Is it time for a reassessment?

1996 • 16 citations

Dietary Restriction, Hormesis, and Small Molecule Mimetics

2005 • 15 citations

Chemosensory and caloric mechanisms influence distinct components of mortality rate

2008 • 11 citations

Dissecting the Processes of Aging Using the Nematode Caenorhabditis elegans

2005 • 11 citations

Hormesis – Implications for risk assessment caloric intake (body weight) as an exemplar

1998 • 10 citations

Vertebrate aging research 2006

2007 • 9 citations

A Critical Evaluation of Nonmammalian Models for Aging Research

2005 • 8 citations

p53 and Mouse Aging Models

2005 • 7 citations

Microarray Analysis of Gene Expression Changes in Aging

2005 • 4 citations