Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women

Exercise Training and Nutritional Supplementation for Physical Frailty in Very Elderly People

1994 • 2,823 citations

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

2001 • 2,539 citations

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

2004 • 1,836 citations

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

2004 • 1,149 citations

A controlled trial

1971 • 982 citations

A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly

2006 • 859 citations

An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein

1997 • 817 citations

Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults

2003 • 797 citations

Intracellular free amino acid concentration in human muscle tissue.

1974 • 733 citations

Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis

1992 • 635 citations

Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis

2006 • 587 citations

Testosterone administration to older men improves muscle function: molecular and physiological mechanisms

2002 • 507 citations

Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis

2004 • 502 citations

Insulin-like Growth Factor-1 (IGF-1) Inversely Regulates Atrophy-induced Genes via the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Pathway

2004 • 498 citations

Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids

2005 • 490 citations

Human Muscle Protein Synthesis is Modulated by Extracellular, Not Intramuscular Amino Acid Availability: A Dose‐Response Study

2003 • 489 citations

Amino acid ingestion improves muscle protein synthesis in the young and elderly

2004 • 454 citations

The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly¹

2000 • 450 citations

Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction

1999 • 417 citations

Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans

2004 • 400 citations

The Recommended Dietary Allowance for Protein May Not Be Adequate for Older People to Maintain Skeletal Muscle

2001 • 393 citations

Exogenous amino acids stimulate net muscle protein synthesis in the elderly.

1998 • 393 citations

Insulin resistance of muscle protein metabolism in aging

2006 • 382 citations

Leg Blood Flow during Exercise in Man

1971 • 378 citations

The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly

2000 • 362 citations

Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis

1993 • 325 citations

Regulation of Muscle Protein by Amino Acids

2002 • 273 citations

Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis

2008 • 253 citations

Stimulation of In Vitro Rat Muscle Protein Synthesis by Leucine Decreases with Age

2000 • 239 citations

Protein-energy oral supplementation in malnourished nursing-home residents. A controlled trial

2000 • 227 citations

Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine

2002 • 226 citations

Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein

2005 • 218 citations

The determination of low d₅‐phenylalanine enrichment (0.002–0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gass chromatography/electron ionization mass spectrometry

1992 • 178 citations

Precursor pools of protein synthesis: a stable isotope study in a swine model

1994 • 134 citations

The effect of oral nutritional supplements on habitual dietary quality and quantity in frail elders.

2000 • 129 citations

An isotopic method for measurement of muscle protein fractional breakdown rate in vivo

1996 • 89 citations

Use of oral supplements in malnourished elderly patients living in the community: a pharmaco-economic study*1

2004 • 85 citations

Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion

2004 • 81 citations

Protein requirements of elderly people.

1996 • 77 citations

Nitrogen balance studies in apparently healthy elderly people and those who are housebound

1987 • 69 citations

Effects of Dietary Carbohydrate Restriction with High Protein Intake on Protein Metabolism and the Somatotropic Axis

2005 • 59 citations

Use of stable isotopically labeled tracers for studies of metabolic kinetics: An overview

1997 • 55 citations

Predictability of body segment volumes in living subjects.

1975 • 43 citations