Opiate Peptide Modulation of Amino Acid Responses Suggests Novel Form of Neuronal Communication

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

1976 • 811 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties

1977 • 510 citations

[D-Ala ² ]-Met-Enkephalinamide: A Potent, Long-Lasting Synthetic Pentapeptide Analgesic

1976 • 466 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Morphine and Enkephalin: Analgesic and Epileptic Properties

1977 • 358 citations

Regional distribution of leu and met enkephalin in rat brain

1977 • 307 citations

Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

1977 • 299 citations

Enkephalin pentapeptides — A review of current evidence for a physiological role in vertebrate neurotransmission

1977 • 269 citations

The regional distribution of a morphine-like factor enkephalin in monkey brain

1976 • 266 citations

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

1976 • 264 citations

Purification and properties of enkephalin — The possible endogenous ligand for the morphine receptor

1975 • 240 citations

Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity

1976 • 216 citations

Morphine, enkephalin and the substantia gelatinosa

1976 • 188 citations

An Analog of Enkephalin Having Prolonged Opiate-Like Effects in Vivo

1977 • 159 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

Enkephalin-Induced Depression of Single Neurons in Brain Areas with Opiate Receptors—Antagonism by Naloxone

1976 • 150 citations

Choline acetyltransferase activity of spinal cord cell cultures increased by co-culture with muscle and by muscle-conditioned medium

1977 • 141 citations

Induction of excessive grooming in the rat by fragments of lipotropin

1976 • 136 citations

Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

1976 • 135 citations

Peptide regulation of neuronal membrane properties

1976 • 108 citations

An electrophysiological approach to drug-receptor mechanisms

1969 • 104 citations

Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent rats

1976 • 97 citations

Effects of enkephalin and morphine on Renshaw cells in feline spinal cord

1976 • 97 citations

Effects of methionine-enkephalin and leucine-enkephalin compared with those of morphine on brainstem neurones in cat

1976 • 94 citations

Depression of nociceptive and other neurones in the brain by iontophoretically applied met-enkephalin

1976 • 87 citations

Enkephalin inhibits firing of myenteric neurones

1976 • 72 citations

Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats

1976 • 56 citations

Peptides with Morphine-like Action in the Brain

1977 • 54 citations

Analgesic activity of enkephalins following intracerebral administration in the rat

1977 • 47 citations

Agonist–antagonist properties of N-allyl-[D-Ala]2-Met-enkephalin

1977 • 26 citations