Morphine and Enkephalin: Analgesic and Epileptic Properties

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 • 811 citations

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

1976 • 811 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

1976 • 664 citations

Autoradiographic localization of opiate receptors in rat brain. II. The brain stem

1977 • 573 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

Noradrenergic neurons: Morphine inhibition of spontaneous activity

1974 • 433 citations

The C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?

1976 • 427 citations

Paradoxical Effects after Microinjection of Morphine in the Periaqueductal Gray Matter in the Rat

1974 • 268 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analogues

1976 • 214 citations

Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat

1974 • 157 citations

Enkephalin-Induced Depression of Single Neurons in Brain Areas with Opiate Receptors—Antagonism by Naloxone

1976 • 150 citations

Effects of pain-attenuating brain stimulation and morphine on electrical activity in the raphe nuclei of the awake rat

1977 • 101 citations

Morphine: Ability to block neuronal activity evoked by a nociceptive stimulus

1976 • 59 citations

Intraventricular Met5-enkephalin causes unexpected lowering of pain threshold and narcotic withdrawal signs in rats

1976 • 56 citations