The μ rather than the δ subtype of opioid receptors appears to be involved in enkephalin-induced analgesia

Individual Comparisons by Ranking Methods

1945 • 12,649 citations

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE

1957 • 1,523 citations

pA, A NEW SCALE FOR THE MEASUREMENT OF DRUG ANTAGONISM

1947 • 759 citations

The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice

1980 • 705 citations

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

1979 • 684 citations

Analogues of β-LPH61–64 posessing selective agonist activity at μ-opiate receptors

1981 • 503 citations

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

1980 • 463 citations

EFFECTS OF CHANGES IN THE STRUCTURE OF ENKEPHALINS AND OF NARCOTIC ANALGESIC DRUGS ON THEIR INTERACTIONS WITH μ‐ AND δ‐RECEPTORS

1980 • 314 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Opiate receptor binding affected differentially by opiates and opioid peptides

1979 • 187 citations

Selective antagonists at the opiate delta-receptor

1982 • 170 citations

Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr: A new highly potent and fully specific agonist for opiate δ-receptors

1983 • 169 citations

D‐Tyr—Ser—Gly—Phe—Leu—Thr, a highly preferential ligand for δ‐opiate receptors

1980 • 165 citations

In vivo evidence for multiple opiate receptors mediating analgesia in the rat spinal cord

1982 • 148 citations

Increase in potencies of opioid peptides after peptidase inhibition

1983 • 143 citations

Participation of both ‘enkephalinase’ and aminopeptidase activities in the metabolism of endogenous enkephalins

1983 • 140 citations

Inhibition of enkepha,in metabolism by, and antinociceptive activity of, bestatin, an aminopeptidase inhibitor

1983 • 139 citations

Selective protection of stereospecific enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors.

1980 • 129 citations

Specific protection of the binding sites of D-Ala ² -D-Leu ⁵ - enkephalin (δ-receptors) and dihydromorphine (μ-receptors)

1979 • 121 citations

Allosteric coupling between morphine and enkephalin receptors in vitro.

1982 • 116 citations

Metkephamid, a Systemically Active Analog of Methionine Enkephalin with Potent Opioid δ-Receptor Activity

1981 • 110 citations

A protein-lipid model of the opiate receptor

1980 • 105 citations

Analgesic activity of intracerebroventricular administration of morphiceptin and β-casomorphins: Correlation with the morphine (μ) receptor binding affinity

1982 • 90 citations

Evidence of the preferential involvement of .mu.-receptors in analgesia using enkephalins highly selective for peripheral .mu. or .delta. receptors

1981 • 72 citations

Improved assays for the assessment of ϰ- and δ-properties of opioid ligands

1982 • 69 citations

evaluation of the opiate delta receptor antagonist ICI 154, 129

1982 • 66 citations

Increased levels of met-enkephalin-like material in the CSF of anaesthetized cats after tooth pulp stimulation

1982 • 60 citations

[3H]Tyr-D-Ser-Gly-Phe-Leu-Thr: A specific probe for the δ-opiate receptor subtype in brain membranes

1982 • 53 citations

Effects of various opiates including specific delta and mu agonists on dopamine release from nigrostriatal dopaminergic neurons in the rat and in the cat

1982 • 44 citations

Inhibitors of a Rat Brain Enkephalin Aminopeptidase

1982 • 41 citations

Cataclysmic conferences show convergence

1980 • 1 citations