Production and assay of the interleukins

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Interleukin-1

1984 • 1,625 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

Structure and expression of a cloned cDNA for human interleukin-2

1983 • 1,176 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

T‐Cell Growth Factor

1980 • 917 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

1984 • 820 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, P cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity

1983 • 702 citations

The functional relationship of the interleukins.

1980 • 660 citations

Interleukin l and T Cell Activation

1982 • 622 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

Immunochemistry in practice

1982 • 514 citations

Thymoma production of T cell growth factor (Interleukin 2).

1980 • 487 citations

Molecular cloning of cDNA for murine interleukin-3

1984 • 485 citations

Hemopoietic colony-stimulating factors

1984 • 468 citations

Regulation of B-Cell Growth and Differentiation by Soluble Factors

1983 • 432 citations

Prostaglandin E inhibits the production of human interleukin 2.

1982 • 423 citations

Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromide

1975 • 417 citations

Human interleukin-2 promotes proliferation of activated B cells via surface receptors similar to those of activated T cells

1984 • 375 citations

Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects.

1984 • 367 citations

Interleukin 2: the molecule and its function

1984 • 367 citations

Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.

1984 • 361 citations

Immunochemistry in Practice

1983 • 355 citations

Epidermal Cell Production of Thymocyte Activating Factor (ETAF)

1982 • 319 citations

Interleukin 1 is more than an interleukin

1982 • 257 citations

Purification to apparent homogeneity of murine interleukin 1.

1981 • 257 citations

Regulation of T cell differentiation: in vitro induction of 20 alpha-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine.

1981 • 252 citations

Constitutive production of a unique lymphokine (IL 3) by the WEHI-3 cell line.

1982 • 227 citations

Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation

1981 • 217 citations

Clones of Killer and Helper T Cells: Growth Requirements, Specificity and Retention of Function in Long‐Term Culture

1980 • 206 citations

Unique structure of murine interleukin-2 as deduced from cloned cDNAs

1985 • 205 citations

Evidence for two distinct classes of murine B cell growth factors with activities in different functional assays.

1983 • 204 citations

Immortalized B lymphocytes produce B-cell growth factor

1984 • 204 citations

Production and characterization of monoclonal antibodies to human interleukin 2: strategy and tactics.

1983 • 203 citations

Heterogeneity of human T-cell growth factor(s) due to variable glycosylation

1981 • 193 citations

Characterization and partial purification of a haemopoietic cell growth factor in WEHI-3 cell conditioned medium

1983 • 192 citations

The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes.

1984 • 186 citations

B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation.

1983 • 182 citations

Differential sensitivity of human B cell subsets to activation signals delivered by anti-mu antibody and proliferative signals delivered by a monoclonal B cell growth factor.

1983 • 179 citations

Interleukin 2: A Class of T Cell Growth Factors

1980 • 178 citations

Induction and Suppression of Polyclonal Antibody Responses by Anti‐Ig Reagents and Antigen‐Nonspecific Helper Factors:

1980 • 169 citations

Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo.

1981 • 166 citations

Interleukin 3: Possible Roles in the Regulation of Lymphocyte Differentiation and Growth

1982 • 157 citations

Purification of human interleukin 2 to apparent homogeneity and its molecular heterogeneity.

1982 • 155 citations

Proliferation of Murine Thymic Lymphocytes in Vitro Is Mediated by the Concanavalin A-Induced Release of a Lymphokine (Costimulator)

1976 • 151 citations

Glucocorticoid inhibition of lymphokine secretion by alloreactive T lymphocyte clones.

1984 • 150 citations

Proliferative responses of normal human B lymphocytes. Development of an assay system for human B cell growth factor (BCGF).

1982 • 142 citations

Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I.

1983 • 136 citations

Long-term in vitro culture of murine mast cells. II. Purification of a mast cell growth factor and its dissociation from TCGF.

1981 • 131 citations

B cell activation: Three steps and their variations

1984 • 130 citations

B Cell Growth and Differentiation Factors

1984 • 126 citations

Biochemical and biologic characterization of lymphocyte regulatory molecules. III. The isolation and phenotypic characterization of Interleukin-2 producing T cell lymphomas.

1980 • 125 citations

Dendritic cells induce T lymphocytes to release B cell-stimulating factors by an interleukin 2-dependent mechanism.

1983 • 118 citations

A rapid biologic assay for the detection of interleukin 1.

1983 • 117 citations

Preparation of lymphocyte-activating factor from continuous murine macrophage cell lines

1977 • 117 citations

The pyrogenic and mitogenic actions of interleukin-1 are related

1983 • 116 citations

A cell line secreting stimulating factors for CFU-GEMM culture

1984 • 113 citations

Establishment of continuous cultures of Thy1.2+, Lytl+,2−T cells with purified interleukin 3

1981 • 112 citations

Interferons as macrophage‐activating factors. II. Enhanced secretion of interleukin 1 by lipopolysaccharide‐stimulated human monocytes

1983 • 112 citations

The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.

1985 • 111 citations

Characterization of human B cell growth factor (BCGF) from cloned T cells or mitogen-stimulated T cells.

1983 • 109 citations

Development of a human T-T cell hybridoma secreting B cell growth factor.

1983 • 104 citations

P cell-stimulating factor: biochemical characterization of a new T cell-derived factor.

1981 • 103 citations

B Cell Growth and Differentiation Factors and Mechanism of B Cell Activation

1984 • 99 citations

A rapid, large scale purification procedure for gibbon interleukin 2.

1983 • 94 citations

The effect of temperature on the activation of thymocytes by interleukins I and II.

1983 • 90 citations

Soluble factor activation of human B lymphocytes

1981 • 80 citations

Long-term culture and cloning of nontransformed human B lymphocytes.

1981 • 78 citations

Thymic reticulum in mice III. Phagocytic cells of the thymic reticulum in culture secrete both prostaglandin E₂ and interleukin 1 which regulate thymocyte proliferation

1983 • 77 citations

The detection of endotoxin by in vitro production of endogenous pyrogen: Comparison with limulus amebocyte lysate gelation

1982 • 74 citations

Quantitative representation of all T cells committed to develop into cytotoxic effector cells and/or interleukin 2 activity‐producing helper cells within murine T lymphocyte subsets

1984 • 69 citations

Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2.

1983 • 68 citations

The Production of Antibody against Human Leukocytic Pyrogen

1977 • 66 citations

T cell-derived B cell growth and differentiation factors. Dichotomy between the responsiveness of B cells from adult and neonatal mice.

1983 • 64 citations

T-cell hybridomas which produce B lymphocyte replication factors only

1982 • 62 citations

Cytotoxic T cells both produce and respond to interleukin 2

1984 • 55 citations

Accessory function of human tumor cell lines I Production of interleukin 1 by the human histiocytic lymphoma cell line U‐937

1982 • 51 citations

Human B cell activation and cell cycle progression: stimulation with anti‐μ and Staphylococcus aureus Cowan strain I

1984 • 48 citations

T-cell growth factors: interleukin 2

1980 • 43 citations

Role of interleukin 1 in antigen-specific T cell proliferation.

1984 • 43 citations

Purification of murine T cell growth factor. A lymphocyte mitogen with helper activity.

1981 • 43 citations

Partial purification and characterization of a BCGFII from EL4 culture supernatants.

1984 • 42 citations

Frequent coexpression of cytolytic activity and lymphokine production among human T lymphocytes. Production of B cell growth factor and interleukin 2 by T8⁺ and T4⁺ cytolytic clones

1984 • 40 citations

Properties of sodium dodecyl sulfate-denatured Interleukin 2.

1981 • 37 citations

Human B cell differentiation. IV. Effect of monoclonal anti-immunoglobulin M and D antibodies on B cell proliferation and differentiation induced by T cell factors.

1983 • 36 citations

Assessment of interleukin 1 and interleukin 2 effects on cycling and noncycling murine thymocytes

1982 • 34 citations

Activation of mouse lymphocytes by anti-immunoglobulin

1984 • 33 citations

An ELISA-based assay for quantitation of human interleukin 2

1984 • 32 citations

Calcium mediates one of the signals required for interleukin 1 and 2 production by murine cell lines

1984 • 31 citations

Characterization of the response of human thymocytes and blood lymphocytes to the synergistic mitogenicity of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) ionomycin

1984 • 31 citations

Purification of mouse interleukin 2 to apparent homogeneity.

1983 • 28 citations

Human B-lymphocyte Function: Activation and Immunoregulation

1982 • 27 citations

Induction of phenotypic differentiation, interleukin 2 production, and PHA responsiveness of "immature" human thymocytes by interleukin 1 and phorbol ester.

1983 • 27 citations

Altered lymphocyte markers and blastogenic responses associated with 24 hour delay in processing of blood samples

1982 • 26 citations

A B cell growth factor-like activity is secreted by cloned, neoplastic B cells.

1984 • 26 citations

Biochemical separation of interleukin 2

1980 • 24 citations

Constitutive production of interleukin 2 activity by a T cell hybridoma.

1981 • 24 citations

Long-term growth of lines of murine dinitrophenyl-specific B lymphocytes in vitro.

1983 • 23 citations

Human B cell proliferation is stimulated by interleukin 2

1985 • 22 citations

Interleukin 1 secretion is not required for human macrophage support of T-cell proliferation

1984 • 19 citations

Triggering of monoclonal human lymphoma B cells with antibodies to IgM heavy chains: differences of response obtained with monoclonal as compared to polyclonal antibodies.

1983 • 17 citations

Relationship of haemopoietic growth factor to lymphocytes and interleukin 3: a short review.

1983 • 17 citations

20α‐Hydroxysteroid dehydrogenase expression in hemopoietic cell cultures and its relationship to interleukin 3

1982 • 15 citations

Development and characterization of interleukin-2-independent antigen-specific human T cell clones that produce multiple lymphokines

1984 • 12 citations

Characterization of a human X mouse T cell hybridoma and identification of a clone secreting and binding interleukin-2.

1984 • 10 citations

Isolation and partial characterization of human T-cell growth factor

1983 • 9 citations

Production of lymphocyte activating factor in vivo.

1983 • 7 citations

Proposed nomenclature for B-cell stimulating factors

1983 • 6 citations

Characterization of a long-term T-helper-cell line which produces IL-2 and induces immunoglobulin secretion

1984 • 4 citations

A mitogenic factor, released by stimulated human mononuclear cells and distinct from interleukin 2 (IL 2), B cell growth factor (BCGF), and interleukin 1 (IL 1).

1984 • 3 citations