Oral Tolerance: New Approaches, New Problems

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Evidence for function of Ia molecules on gut epithelial cells in man.

1987 • 521 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Generalized systemic and mucosal immunity in mice after mucosal stimulation with cholera toxin.

1984 • 445 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity

1997 • 305 citations

Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein

1988 • 291 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.

1986 • 252 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen.

1990 • 229 citations

Treatment of rheumatoid arthritis with oral type II collagen: Results of a multicenter, double-blind, placebo-controlled trial

1998 • 219 citations

IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis

1998 • 218 citations

Poliovirus type 1 enters the human host through intestinal M cells

1990 • 215 citations

Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in the murine Peyer's patch after protein feeding.

1981 • 195 citations

Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols.

1993 • 184 citations

Mechanism for transforming growth factor beta and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures.

1990 • 183 citations

Mechanisms for Mucosal Immunogenicity and Adjuvancy of Escherichia coli Labile Enterotoxin

1996 • 173 citations

Treatment of Uveitis by Oral Administration of Retinal Antigens: Results of a Phase I/II Randomized Masked Trial

1997 • 155 citations

In Situ Immune Response in Gut-Associated Lymphoid Tissue (GALT) Following Oral Antigen in TCR-Transgenic Mice

1998 • 145 citations

Oral but Not Parenteral Interleukin (IL)-12 Redirects T Helper 2 (Th2)-type Responses to an Oral Vaccine Without Altering Mucosal IgA Responses

1997 • 124 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin

1994 • 119 citations

In vivo tolerization of Th1 lymphocytes following a single feeding with ovalbumin: Anergy in the absence of suppression

1994 • 113 citations

Orally inducible immune unresponsiveness is abrogated by IFN-gamma treatment.

1990 • 113 citations

Oral tolerance.

1998 • 102 citations

Oral administration of acetylcholine receptor: Effects on experimental myasthenia gravis

1994 • 100 citations

Isolation and purification of CD14-negative mucosal macrophages from normal human small intestine

1997 • 99 citations

Mechanisms of Oral Tolerance

1997 • 96 citations

Oral tolerance to ovalbumin in mice: studies of chemically modified and 'biologically filtered' antigen.

1986 • 90 citations

Studies on the induction of tolerance to alloantigens. I. The abrogation of potentials for delayed-type-hypersensitivity response to alloantigens by portal venous inoculation with allogeneic cells.

1985 • 85 citations

Differential regulation of B7 mRNA in enterocytes and lymphoid cells.

1993 • 84 citations

The influence of intestinal processing on the immunogenicity and molecular size of absorbed, circulating ovalbumin in mice.

1986 • 78 citations

Mechanisms of Nasal Tolerance Induction in Experimental Autoimmune Myasthenia Gravis: Identification of Regulatory Cells

1999 • 75 citations

Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans.

1997 • 73 citations

Suppression of Collagen Induced Arthritis by Oral Administration of Type II Collagen: Changes in Immune and Arthritic Responses Mediated by Active Peripheral Suppression

1993 • 71 citations

Oral Administration of Myelin Basic Protein Is Superior to Myelin in Suppressing Established Relapsing Experimental Autoimmune Encephalomyelitis

1999 • 70 citations

Lack of oral tolerance but oral priming for contact sensitivity to dinitrofluorobenzene in major histocompatibility complex class II‐deficient mice and in CD4⁺ T cell‐depleted mice

1996 • 68 citations

Rat intestinal dendritic cells: immunostimulatory potency and phenotypic characterization.

1995 • 67 citations

Characterization of the specificity and duration of T cell tolerance to intranasally administered peptides in mice: a role for intramolecular epitope suppression

1997 • 66 citations

Characterization of a 180-kDa Intestinal Epithelial Cell Membrane Glycoprotein, gp180

1997 • 66 citations

T cell immunity to oral allergens

1998 • 64 citations

Amino acid and peptide absorption from the gastrointestinal tract.

1986 • 54 citations

Intraocular Inflammatory Disease (Uveitis) and the Use of Oral Tolerance.

1996 • 54 citations

The role of antigen recognition and suppressor cells in mice with oral tolerance to ovalbumin.

1985 • 53 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein VI. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization

1993 • 52 citations

Oral Tolerization Leads to Active Suppression and Bystander Tolerance in Adult Rats while Anergy Dominates in Young Rats

1996 • 50 citations

Inhibition of relapsing experimental autoimmune encephalomyelitis in SJL mice by feeding the immunodominant PLP139-151 peptide

1996 • 48 citations

Genetic differences in immune exclusion and partial tolerance to ingested antigens.

1983 • 42 citations

Inactivation of Th1 and Th2 Cells by Feeding Ovalbumina

1996 • 39 citations

ORAL TOLERIZATION AS A TREATMENT OF RHEUMATOID ARTHRITIS

1998 • 38 citations

Abrogation by subsequent feeding of antibody response including IgE, in parenterally immunized mice.

1982 • 38 citations

Chemical Denaturation of Ovalbumin Abrogates the Induction of Oral Tolerance of Specific IgG Antibody and DTH Responses in Mice

1995 • 35 citations

Immunosuppression of thyroiditis.

1996 • 35 citations

Induction of Anergy in Th1 Lymphocytes by Oral Tolerance.

1996 • 35 citations

Induction of Oral Tolerance in Human Autoimmune Thyroid Disease

1998 • 34 citations

Clonal Anergy Is a Potent Mechanism of Oral Tolerance in the Suppression of Acute Antigen-Induced Arthritis in Rats by Oral Administration of the Inducing Antigen

1997 • 33 citations

Oral tolerance : mechanisms and applications

1996 • 31 citations

CD8 T-Cells Are Not Essential for the Induction of “Low-Dose” Oral Tolerance

1996 • 29 citations

Induction of clonal anergy by oral administration of staphylococcal enterotoxin B

1994 • 28 citations

Modulation of experimental autoimmune neuritis in Lewis rats by oral application of myelin antigens

1997 • 28 citations

The role of clonal deletion and anergy in oral tolerance

1997 • 27 citations

The Role of Dendritic Cells in Antigen Processing in the Peyer's Patch

1996 • 27 citations

Mechanisms of Oral Tolerance by MHC Peptides

1996 • 26 citations

Studies on the induction of tolerance to alloantigens. III. Induction of antibodies directed against alloantigen-specific delayed-type hypersensitivity T cells by a single injection of allogeneic lymphocytes via portal venous route.

1988 • 26 citations

Introduction

1996 • 25 citations

Oral tolerance: Elucidation of mechanisms and application to treatment of autoimmune diseases

1997 • 20 citations

ORAL TOLERANCE AND ACCESSORY‐CELL FUNCTION OF PEYER'S PATCHES

1983 • 19 citations

Arthritis: Animal Models of Oral Tolerancea

1996 • 16 citations

Oral tolerance: mechanisms and possible role in inflammatory joint diseases

1996 • 12 citations

New Strategies in Oral Immunotherapy for Diabetes Prevention

1996 • 11 citations

New Strategies in Oral Immunotherapy for Diabetes Prevention

1996 • 10 citations

Oral tolerance: mechanisms and therapy of autoimmune diseases.

1998 • 9 citations

The influence of antigen digestion on orally induced immunity and tolerance.

1995 • 9 citations

Heterologous epitopes of IRBP protect against autoimmune uveitis induced by the autologous epitope

1998 • 8 citations

[Immunologic suppression of experimental autoimmune uveitis].

1991 • 8 citations

T-cell regulation

1995 • 7 citations

Suppression of Adjuvant Arthritis in Rats by Oral Administration of Type II Collagen in Combination with Type I Interferon

1996 • 7 citations

Orally administered cholera toxin prevents murine intestinal T cells from staphylococcal enterotoxin B-induced anergy

1998 • 7 citations

Induction of Tolerance in Rodent Cardiac Allotransplantation Using an MHC Class I-Derived Peptide and Cyclosporin A

1998 • 7 citations

Oral Tolerance in Autoimmune Encephalomyelitis.

1996 • 2 citations

Characteristic immunological tolerance in intrahepatic lymphocytes induced by bacterial superantigen SEB.

1996 • 1 citations