T cell immunity to oral allergens

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease

1998 • 1,158 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Oral tolerance: immune mechanisms and treatment of autoimmune diseases

1997 • 757 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Handbook of Mucosal Immunology

1994 • 711 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

1993 • 549 citations

Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.

1996 • 487 citations

Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease

1998 • 460 citations

Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy.

1991 • 450 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Regulation of IgE Responses to Inhaled Antigen in Mice by Antigen-Specific γδ T Cells

1994 • 406 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma.

1995 • 346 citations

Expanding Dendritic Cells In Vivo Enhances the Induction of Oral Tolerance

1998 • 327 citations

Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells.

1996 • 260 citations

Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite-induced rhinoconjunctivitis

1998 • 259 citations

Immunohistochemical observations on lymphoid tissues from conventional and germ-free mice.

1970 • 238 citations

Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy☆☆☆★★★

1997 • 237 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

High dose oral tolerance in ovalbumin TCR-transgenic mice: systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis.

1996 • 221 citations

Treatment of rheumatoid arthritis with oral type II collagen: Results of a multicenter, double-blind, placebo-controlled trial

1998 • 219 citations

Induction of Rapid T Cell Activation and Tolerance by Systemic Presentation of an Orally Administered Antigen

1998 • 219 citations

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

1992 • 186 citations

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

1997 • 180 citations

T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction.

1995 • 171 citations

In Situ Immune Response in Gut-Associated Lymphoid Tissue (GALT) Following Oral Antigen in TCR-Transgenic Mice

1998 • 145 citations

Monocyte Chemotactic Protein 1 Regulates Oral Tolerance Induction by Inhibition of T Helper Cell 1–related Cytokines

1998 • 138 citations

Direct measurement of anergy of antigen-specific T cells following oral tolerance induction.

1996 • 118 citations

Activation and migration of CD8 T cells in the intestinal mucosa.

1997 • 102 citations

Milk-responsive atopic dermatitis is associated with a casein-specific lymphocyte response in adolescent and adult patients

1997 • 99 citations

Inductive Events in Oral Tolerance in the TCR Transgenic Adoptive Transfer Model

1997 • 98 citations

The role of circulating food antigen-specific lymphocytes in food allergic children with atopic dermatitis

1996 • 93 citations

The Frequency of Cells Secreting Interferon-γ and Interleukin-4, -5, and -10 in the Blood and Duodenal Mucosa of Children with Cow's Milk Hypersensitivity

1997 • 92 citations

TGF-beta induced by oral tolerance ameliorates experimental tracheal eosinophilia.

1997 • 90 citations

Oral Tolerance and Regulation of Immunity to Dietary Antigens

1994 • 86 citations

Effector and Regulatory Lymphoid Cells and Cytokines in Mucosal Sites

1999 • 83 citations

Lack of orally induced systemic unresponsiveness in IFN-gamma knockout mice.

1998 • 81 citations

Regulation of transforming growth factor‐β production by interleukin‐12

1997 • 77 citations

The role of small intestinal antigen‐presenting cells in the induction of T‐cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance

1996 • 64 citations

Lack of Local Suppression in Orally Tolerant CD8-Deficient Mice Reveals a Critical Regulatory Role of CD8+ T Cells in the Normal Gut Mucosa

1998 • 63 citations

Lack of Orally Induced Systemic Unresponsiveness in IFN-γ Knockout Mice

1998 • 61 citations

Food allergen (peanut)–specific T clones generated from the peripheral blood of a patient with peanut allergy

1996 • 59 citations

Dendritic Cells from Peyer's Patch and Spleen Induce Different T Helper Cell Responses

1998 • 53 citations

Functional differentiation of T cells in the intestine of T cell receptor transgenic mice

1997 • 51 citations

A Helminth-Induced Mucosal Th2 Response Alters Nonresponsiveness to Oral Administration of a Soluble Antigen

1998 • 49 citations

Phenotypes of T Cells in the Gut

1998 • 46 citations

Blockage of T-cell costimulation inhibits T-cell action in celiac disease

1998 • 46 citations

Polyclonal and clonal analysis of human CD4+ T-lymphocyte responses to nut extracts.

1995 • 44 citations

Cytokines in the Mucosal Immune System

1994 • 42 citations

Gamma‐interferon production in cow milk allergy

1993 • 41 citations

Lymphocytes from orally tolerized mice display enhanced susceptibility to death by apoptosis when cultured in the absence of antigen in vitro.

1996 • 37 citations

Interleukin‐4 and interferon‐gamma production by peripheral bloGd mononuclear cells from food‐allergic patients

1996 • 37 citations

The cow milk allergy complex: overlapping disease profiles in infancy.

1995 • 34 citations

Reversal of mucosal tolerance by subcutaneous administration of interleukin‐12 at the site of attempted sensitization

1996 • 29 citations

Modulation of experimental autoimmune neuritis in Lewis rats by oral application of myelin antigens

1997 • 28 citations

Selective suppression of antigen-specific Th2 cells by continuous micro-dose oral tolerance

1998 • 25 citations

CD4⁺ cells proliferate after peanut‐extract‐specific and CD8⁺ cells proliferate after polyclonal stimulation of PBMC of children with atopic dermatitis

1998 • 25 citations

Oral cow milk challenge abolishes antigen‐specific interferon‐γ production in the peripheral blood of children with atopic dermatitis and cow milk allergy

1997 • 24 citations

Interleukin-4 and interferon-gamma production by peripheral blood mononuclear cells from food-allergic patients

1996 • 22 citations

Establishment and characterization of αs1-casein–specific T-cell lines from patients allergic to cow’s milk: Unexpected higher frequency of CD8+ T-cell lines

1996 • 17 citations

Inhibition of Airway Inflammation in rDer f 2-Sensitized Mice by Oral Administration of Recombinant Der f 2

1997 • 14 citations

T-Cell Response to Orally Administered Antigens and Its Role in the Treatment of Antoimmune Diseases

1998 • 6 citations