The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor Theory

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

A MODIFICATION OF RECEPTOR THEORY

1956 • 1,126 citations

On some physiological actions of ergot

1906 • 980 citations

Chemical structure and sympathomimetic action of amines

1910 • 720 citations

The Uptake and Storage of Noradrenaline in Sympathetic Nerves

1967 • 706 citations

ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*

1967 • 682 citations

Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.

1953 • 643 citations

Advances in Drug Research

1964 • 615 citations

Molecular Pharmacology

1964 • 599 citations

On the reaction of cells and of nerve‐endings to certain poisons, chiefly as regards the reaction of striated muscle to nicotine and to curari

1905 • 581 citations

Effects of Lipolytic and Antilipolytic Substances on Adenosine 3′,5′-Monophosphate Levels in Isolated Fat Cells

1968 • 555 citations

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

1967 • 517 citations

Differentiation of receptors responsive to isoproterenol

1967 • 484 citations

The Pharmacology of Vascular Smooth Muscle

1996 • 435 citations

A theory of drug action based on the rate of drug-receptor combination

1961 • 430 citations

SELECTIVE BLOCKADE OF ADRENOCEPTIVE BETA RECEPTORS IN THE HEART

1968 • 415 citations

THE PHARMACOLOGICAL DIFFERENTIATION OF ADRENERGIC RECEPTORS*

1967 • 376 citations

Blocking of inhibitory adrenergic receptors by a dichloro analog of isoproterenol.

1958 • 373 citations

Sympathetic regulation of metabolism.

1967 • 338 citations

Actions of sympathomimetic amines and their antagonists on skeletal muscle.

1969 • 272 citations

pA_x AND COMPETITIVE DRUG ANTAGONISM

1949 • 247 citations

Ciba Foundation Symposium - Adrenergic Mechanisms

1961 • 220 citations

Adrenergic blockade of the mammalian heart by a dichloro analogue of isoproterenol.

1958 • 218 citations

EVALUATION OF THE CARDIAC EFFECTS OF SEVERAL BETA ADRENERGIC BLOCKING AGENTS

1967 • 205 citations

Central Synaptic Transmission-Microelectrophoretic Studies

1969 • 203 citations

THE PHARMACOLOGY OF ADRENERGIC BLOCKADE

1949 • 203 citations

ACTIONS AND INTERACTIONS OF NOREPINEPHRINE, TYRAMINE AND COCAINE ON AORTIC STRIPS OF RABBIT AND LEFT ATRIA OF GUINEA PIG AND CAT.

1963 • 199 citations

Importance of fundamental principles in drug evaluation

1968 • 196 citations

The receptors for epinephrine and norepinephrine (adrenergic receptors).

1959 • 180 citations

Dibenamine blockade in strips of rabbit aorta and its use in differentiating receptors.

1954 • 165 citations

Andrenergic receptive mechanism of canine ileum.

1959 • 150 citations

Myocardial alpha adrenergic receptors and their role in the production of a positive inotropic effect by sympathomimetic agents.

1968 • 146 citations

THE ANTIARRHYTHMIC ACTIONS OF BETA ADRENERGIC BLOCKING AGENTS.

1965 • 143 citations

THE STRUCTURE‐ACTIVITY RELATIONSHIPS OF BETA ADRENERGIC DRUGS AND BETA ADRENERGIC BLOCKING DRUGS

1967 • 131 citations

Different types of sympathomimetic α-receptors

1965 • 129 citations

The effect of a saturable uptake mechanism on the slopes of dose-response curves for sympathomimetic amines and on the shifts of dose-response curves produced by a competitive antagonist.

1969 • 127 citations

Methoxamine as a tool to assess the importance of intraneuronal uptake of l-norepinephrine in the cat's nictitating membrane.

1970 • 127 citations

The kinetics of action of acetylcholine antagonists in smooth muscle

1966 • 122 citations

Physiologic and Pharmacologic Considerations of Biogenic Amines in the Nervous System

1968 • 118 citations

Adrenergic receptors in the veins of the dog

1969 • 110 citations

The adrenergic blocking activity of N-tert.-butylmethoxamine (butoxamine).

1966 • 110 citations

Evidence favouring the Existence of a Single Adrenergic Receptor

1968 • 107 citations

Receptor Mechanisms

1964 • 107 citations

ADRENERGIC RECEPTORS IN CORONARY ARTERIES*

1967 • 103 citations

Inhibition of rabbit intestine mediated by α‐ and β‐adrenoceptors

1970 • 100 citations

The Adrenergic Receptor

1966 • 94 citations

ANTIARRHYTHMIC EFFECTS OF BETA ADRENERGIC BLOCKING AGENTS*

1967 • 93 citations

INHIBITION OF LIPID MOBILIZATION BY N-ISOPROPYL METHOXAMINE (B.W. 61-43).

1964 • 88 citations

ADRENERGIC BLOCKADE OF HORMONE‐INDUCED LIPOLYSIS IN ISOLATED FAT CELLS*

1967 • 85 citations

Analysis of beta receptor drug interactions in isolated rabbit atrium, aorta, stomach and trachea.

1970 • 84 citations

INTERACTIONS OF SYMPATHOMIMETIC DRUGS, PROPRANOLOL AND PHENTOLAMINE, ON ATRIAL REFRACTORY PERIOD AND CONTRACTILITY

1967 • 82 citations

Myocardial alpha and beta adrenergic receptors as demonstrated by atrial functional refractory-period changes.

1966 • 81 citations

The nature of the adrenergic receptors of the trachea of the guinea-pig

1966 • 80 citations

Steric Aspects of Adrenergic Drugs

1970 • 79 citations

Pharmacological characteristics of adrenergic receptors.

1970 • 77 citations

Suppression of spontaneous spike generation by catecholamines in the smooth muscle of the guinea-pig taenia coli

1969 • 76 citations

ADRENERGIC RECEPTORS IN THE MYOMETRIUM

1967 • 75 citations

Disposition of norepinephrine and epinephrine in vascular tissue, determined by the technique of oil immersion.

1969 • 75 citations

Uptake of propranolol by isolated guinea-pig atria.

1967 • 70 citations

THE ADRENERGIC RECEPTIVE MECHANISM OF THE RAT UTERUS.

1963 • 69 citations

Temperature modulation of α‐ and β‐adrenoceptors in the isolated frog heart

1970 • 68 citations

The effects of some β‐adrenoreceptor blocking drugs on the uptake and release of noradrenaline by the heart

1968 • 66 citations

The rate of action of atropine.

1968 • 64 citations

A comparison of the β-adrenoreceptor stimulant properties of isoprenaline, with those of orciprenaline, salbutamol, soterenol and trimetoquinol on isolated atria and trachea of the guinea-pig

1970 • 63 citations

A new preparation of the isolated intact trachea of the guinea-pig

1970 • 57 citations

THE POTENTIATION OF THE RESPONSES TO NORADRENALINE AND ISOPRENALINE OF THE GUINEA‐PIG ISOLATED TRACHEAL CHAIN PREPARATION BY DESIPRAMINE, COCAINE, PHENTOLAMINE, PHENOXYBENZAMINE, GUANETHIDINE, METANEPHRINE AND COOLING

1967 • 56 citations

BLOCKADE OF THE BIOCHEMICAL CORRELATES OF CONTRACTION AND RELAXATION IN UTERINE AND INTESTINAL SMOOTH MUSCLE*

1967 • 54 citations

Steric aspects of adrenergic drugs. 8. Optical isomers of beta adrenergic receptor antagonists.

1968 • 52 citations

AUTONOMIC CONTROL OF METABOLISM*

1967 • 52 citations

Steric aspects of adrenergic drugs. XVI. Beta adrenergic receptors of guinea-pig atria and trachea.

1971 • 50 citations

Adrenergic receptors for metabolic responses in adipose tissue.

1970 • 48 citations

Receptor-reserve and threshold-phenomena. II. Theories on drug-action and a quantitative approach to spare receptors and threshold values.

1962 • 48 citations

An uptake of radioactivity from (±)‐³H‐isoprenaline and its inhibition by drugs which potentiate the responses to (—)‐isoprenaline in the guinea‐pig isolated trachea

1969 • 47 citations

THE DEVELOPMENT OF BETA ADRENERGIC BLOCKING DRUGS: A RETROSPECTIVE AND PROSPECTIVE EVALUATION*

1967 • 47 citations

MODIFICATION BY RESERPINE OF THE RESPONSE OF THE ATRIAL PACEMAKER TO SYMPATHOMIMETIC AMINES.

1963 • 46 citations

A Pharmacological Investigation of Human Isolated Ileum

1965 • 43 citations

Comparison of the action of isoproterenol and several related compounds on blood pressure, heart and bronchioles.

1966 • 42 citations

Ganglionic Transmission

1969 • 40 citations

THE RESPONSE OF ISOLATED STRIPS OF CAT SPLEEN TO SYMPATHOMIMETIC DRUGS AND THEIR ANTAGONISTS.

1963 • 39 citations

Analysis of supersensitivity in the isolated spleen of the cat.

1968 • 38 citations

Central adrenergic synapses.

1966 • 37 citations

Steric aspects of adrenegic drugs. XV. Use of isomeric activity ratio as a criterion to differentiate adrenergic receptors.

1971 • 37 citations

Differentiation of β-adrenoreceptors by the use of blocking agents

1970 • 34 citations

THE USE OF DRUG ANTAGONISTS FOR THE IDENTIFICATION AND CLASSIFICATION OF DRUGS

1947 • 34 citations

The interaction of cocaine and propranolol with catecholamines on guinea pig trachea

1967 • 34 citations

INTERACTIONS BETWEEN POTENTIATING AGENTS OF ADRENERGIC AMINES IN RABBIT AORTIC STRIPS

1970 • 33 citations

Adrenergic receptors for metabolic responses in the liver.

1970 • 33 citations

The mathematics of drug-receptor interactions

1966 • 30 citations

Studies on a biphasic lipolytic response to catecholamines in isolated fat cells

1969 • 30 citations

Effects of a haloalkylamine on responses to and disposition of sympathomimetic amines

1969 • 30 citations

The beta-2 receptor mediated glycogenolytic responses to catecholamines in the dog.

1968 • 29 citations

Activities of catecholamines on the rat muscle glycogenolytic (β-2) receptor

1968 • 28 citations

NEW DEVELOPMENTS IN ADRENERGIC BLOCKING DRUGS*

1967 • 27 citations

Receptors for Sympathomimetic Amines

2008 • 27 citations

ADRENERGIC BLOCKING DRUGS AS TOOLS IN THE STUDY OF THE ACTIONS OF CATECHOLAMINES ON THE SMOOTH MUSCLE MEMBRANE

1967 • 26 citations

Relative sensitivity of some large blood vessels of the rabbit to sympathomimetic amines.

1965 • 25 citations

EVIDENCE FOR A SYMPATHETIC ALPHA RECEPTOR BLOCKING ACTION OF BETA RECEPTOR BLOCKING AGENTS

1969 • 25 citations

RELAXATION OF THE NICTITATING MEMBRANE OF THE SPINAL CAT BY SYMPATHOMIMETIC AMINES.

1963 • 24 citations

The presence of antagonistically acting alpha and beta adrenergic receptors in the mouse spleen.

1968 • 24 citations

Effects of adrenergic blocking agents on epinephrine- and 3',5'-amp-induced responses in the perfused rat liver.

1968 • 24 citations

A potent β-adrenoreceptor blocking drug: 4-(2-hydroxy-3-isopropylaminopropoxy)indole

1970 • 23 citations

Beta-receptors in human isolated smooth muscle.

1969 • 23 citations

A CORRELATION BETWEEN INHIBITION OF THE UPTAKE OF ³H FROM (±)‐³H‐NORADRENALINE AND POTENTIATION OF THE RESPONSES TO (–)‐NORADRENALINE IN THE GUINEA‐PIG ISOLATED TRACHEA

1968 • 23 citations

METABOLIC BLOCKADE BY METHOXAMINE AND ITS ANALOGS

1967 • 22 citations

Steric aspects of adrenergic drugs. XI. Interactions of dibenamine and beta adrenergic blockers.

1968 • 22 citations

THE POTENTIATION AND PARALYSIS OF ADRENERGIC EFFECTS BY ERGOTOXINE AND OTHER SUBSTANCES

1941 • 22 citations

Dihydroergotamine, propranolol and the beta adrenergic receptors of fat cells.

1970 • 21 citations

The antagonism of phentolamine against exogenously administered and endogenously released norepinephrine in rabbit aortic strips.

1970 • 21 citations

Die Wirkung von α- und β-Sympathomimetica und Sympatholytica auf die renale Exkretion und Resorption von Flüssigkeit und Elektrolyten in Ausscheidungs- und Mikropunktionsversuchen an Ratten

1969 • 21 citations

Adrenotrophic β-receptors in the frog and chicken

1969 • 20 citations

The effect of ergotamine on humoral and neuronal actions in the nictitating membrane and the spleen of the cat

1968 • 20 citations

Relative potencies of sympathetic amines in human smooth muscle.

1969 • 20 citations

α-Adrenergic blocking action of propranolol

1967 • 20 citations

The actions of dichloroisoproterenol in the dog heart-lung preparation and the isolated guinea-pig atrium.

1960 • 20 citations

Adrenergic receptors of the bovine iris sphincter.

1969 • 19 citations

SOME ASPECTS OF THE ACTION OF BETA ADRENERGIC BLOCKING DRUGS ON ADRENERGIC LIPID MOBILIZATION

1967 • 17 citations

Selective interactions with beta adrenergic receptors.

1970 • 16 citations

Adrenergic Receptors in the Guinea Pig Trachea and Lung

1969 • 16 citations

The adrenergic receptors of the coronary circulation in the isolated dog heart.

1969 • 15 citations

Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea‐pig

1968 • 14 citations

Specificity of β-receptor antagonists

1968 • 14 citations

Effect of beta adrenergic receptor blockade on skeletal muscle vasodilatation produced by isoxsuprine and nylidrin.

1968 • 13 citations

Bedeutung der N- und ?-Methylierung f�r die Affinit�t von Brenzcatechinaminen zu den adrenergischen Receptoren

1967 • 13 citations

Separation of the effects of alpha and beta adrenergic receptor stimulation on taenia coli.

1969 • 12 citations

RECEPTORS FOR SYMPATHOMIMETIC AMINES IN THE RABBIT AORTA: DIFFERENTIATION BY SPECIFIC ANTAGONISTS

1968 • 12 citations

Adrenergic receptors for metabolic responses in skeletal and smooth muscles.

1970 • 12 citations

THE EFFECT OF ADRENALINE AND NORADRENALINE ON THE ACTIVITY OF ISOLATED PREPARATIONS OF THE GUT FROM THE FOETAL GUINEA‐PIG

1953 • 11 citations

Guinea-pig adipose tissue responsiveness to catecholamines

1968 • 11 citations

Adrenergic receptors for metabolic responses in the heart.

1970 • 8 citations

Insulin and adrenergic receptors.

1970 • 8 citations

BETA-ADRENERGIC RECEPTORS IN VARIOUS ORGANS

1970 • 8 citations

Blockade of catecholamine mediated release of free fatty acids from adipose tissue in vitro.

1967 • 7 citations

An evaluation of the adrenergic receptor types in isolated segments of the small intestine of the rabbit.

1968 • 7 citations

ADRENERGIC CONSTRICTION IN ISOLATED GUINEA-PIG LING REVEALED BY NETHALIDE.

1964 • 6 citations

Dichloroisoproterenol blockade of the rabbit aortic strip.

1963 • 6 citations

Correlation of calorigenesis with other beta-1 receptor mediated responses to catecholamines.

1969 • 5 citations

Selective beta receptor blockade in rat smooth muscle.

1967 • 5 citations

Effects of two beta-adrenergic blocking agents, propranolol and INPEA, on lipid metabolism.

1967 • 5 citations

Steric aspects of adrenergic drugs VII Certain pharmacological actions of d(−)-pseudoephedrine

1967 • 5 citations

The effects of beta adrenoceptor blocking agents on the membrane potential and spike generation in the smooth muscle of guinea‐pig taenia coli

1970 • 5 citations

Comparison of lipomobilizing effects of norepinephrine and phenyl-t-butyl-noroxedrine in vitro.

1967 • 1 citations