Thermotolerance Requires Refolding of Aggregated Proteins by Substrate Translocation through the Central Pore of ClpB

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

2002 • 3,280 citations

Hsp104, Hsp70, and Hsp40

1998 • 1,346 citations

Posttranslational Quality Control: Folding, Refolding, and Degrading Proteins

1999 • 1,064 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

HSP104 Required for Induced Thermotolerance

1990 • 822 citations

Addition of a photocrosslinking amino acid to the genetic code of Escherichia coli

2002 • 680 citations

Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB

1999 • 587 citations

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

1999 • 578 citations

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA

1999 • 427 citations

The Structure of ClpB

2003 • 426 citations

Dynamics of Substrate Denaturation and Translocation by the ClpXP Degradation Machine

2000 • 336 citations

ClpB is the Escherichia coli heat shock protein F84.1

1991 • 336 citations

Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol

2001 • 332 citations

Refolding of Substrates Bound to Small Hsps Relies on a Disaggregation Reaction Mediated Most Efficiently by ClpB/DnaK

2003 • 280 citations

Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

2001 • 263 citations

Heat-inactivated proteins are rescued by the DnaK⋅J-GrpE set and ClpB chaperones

1999 • 252 citations

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP

2000 • 249 citations

Roles of Individual Domains and Conserved Motifs of the AAA+ Chaperone ClpB in Oligomerization, ATP Hydrolysis, and Chaperone Activity

2003 • 240 citations

Evidence for an Unfolding/Threading Mechanism for Protein Disaggregation by Saccharomyces cerevisiae Hsp104

2004 • 237 citations

Review: Mechanisms of Disaggregation and Refolding of Stable Protein Aggregates by Molecular Chaperones

2001 • 237 citations

Crystal Structures of the HslVU Peptidase–ATPase Complex Reveal an ATP-Dependent Proteolysis Mechanism

2001 • 233 citations

Size-dependent Disaggregation of Stable Protein Aggregates by the DnaK Chaperone Machinery

2000 • 226 citations

Substrate recognition by the AAA+ chaperone ClpB

2004 • 225 citations

Crystal Structure of ClpA, an Hsp100 Chaperone and Regulator of ClpAP Protease

2002 • 202 citations

Visualization of Substrate Binding and Translocation by the ATP-Dependent Protease, ClpXP

2000 • 172 citations

Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates

2004 • 166 citations

Characterization of a Trap Mutant of the AAA+ Chaperone ClpB

2003 • 157 citations

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP

2000 • 154 citations

ClpA mediates directional translocation of substrate proteins into the ClpP protease

2001 • 148 citations

Communication between ClpX and ClpP during substrate processing and degradation

2004 • 148 citations

Mitochondrial Hsp78, a member of the Clp/Hsp100 family in Saccharomyces cerevisiae, cooperates with Hsp70 in protein refolding

2001 • 141 citations

Mutational studies on HslU and its docking mode with HslV

2000 • 136 citations

Conserved Pore Residues in the AAA Protease FtsH Are Important for Proteolysis and Its Coupling to ATP Hydrolysis

2003 • 130 citations

Defining a Pathway of Communication from the C-Terminal Peptide Binding Domain to the N-Terminal ATPase Domain in a AAA Protein

2002 • 123 citations

Identification and purification of the Lon ⁺ (capR ⁺ ) gene product, a DNA-binding protein

1981 • 95 citations

ClpAP and ClpXP degrade proteins with tags located in the interior of the primary sequence

2002 • 85 citations

Increased ubiquitin-dependent degradation can replace the essential requirement for heat shock protein induction

2003 • 80 citations

A Chaperone Network for the Resolubilization of Protein Aggregates: Direct Interaction of ClpB and DnaK

2003 • 79 citations

Structure and Function of the Middle Domain of ClpB fromEscherichia coli

2003 • 68 citations

Protein Binding and Disruption by Clp/Hsp100 Chaperones

2004 • 61 citations

Cooperative Action of Escherichia coli ClpB Protein and DnaK Chaperone in the Activation of a Replication Initiation Protein

2002 • 50 citations