GABAA receptor pharmacology

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

GABA_A Receptor Channels

1994 • 1,948 citations

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

Benzodiazepine receptors in rat brain

1977 • 1,459 citations

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

1989 • 1,283 citations

Amino acid transmitters in the mammalian central nervous system

1974 • 1,169 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Phospholipid Methylation and Biological Signal Transmission

1980 • 1,101 citations

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1981 • 1,044 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

A Review of Psychoendocrine Research on the Pituitary-Adrenal Cortical System

1968 • 874 citations

Pharmacological studies on presynaptic inhibition

1963 • 765 citations

GABAergic modulation of benzodiazepine binding site sensitivity

1978 • 726 citations

Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat

1971 • 685 citations

Ionic basis of GABAA receptor channel function in the nervous system

1994 • 679 citations

Interaction of Convulsive Ligands with Benzodiazepine Receptors

1982 • 549 citations

GABA, Bicuculline and Central Inhibition

1970 • 545 citations

Quantal analysis of inhibitory synaptic transmission in the dentate gyrus of rat hippocampal slices: a patch‐clamp study.

1990 • 545 citations

Evolutionary history of the ligand-gated ion-channel superfamily of receptors

1995 • 535 citations

Modulation of the GABA receptor complex by a steroid anaesthetic

1984 • 496 citations

Modulation of the N-methyl-D-aspartate channel by extracellular H+.

1990 • 458 citations

Potentiation of NMDA receptor currents by arachidonic acid

1992 • 428 citations

Quaternary Structure of the Native GABA_A Receptor Determined by Electron Microscopic Image Analysis

1994 • 423 citations

GABAA receptor needs two homologous domains of the & beta;-subunit for activation by GABA but not by pentobarbital

1993 • 417 citations

Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

1995 • 408 citations

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

1993 • 402 citations

GABAA receptors: ligand-gated Cl− ion channels modulated by multiple drug-binding sites

1992 • 382 citations

CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS¹

1942 • 348 citations

A new class of GABA agonist

1977 • 338 citations

Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.

1991 • 338 citations

INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY NIPECOTIC ACID, VARIOUS ISOXAZOLES AND RELATED COMPOUNDS

1975 • 329 citations

Functional Modulation of GABA _A Receptors by cAMP-Dependent Protein Phosphorylation

1992 • 322 citations

Physiological evidence for two distinct GABAA responses in rat hippocampus

1993 • 304 citations

Neurosteroids: a new function in the brain

1991 • 296 citations

Zolpidem

1990 • 290 citations

STRUCTURE AND BIOLOGICAL ACTIVITY OF A SERIES OF CONFORMATIONALLY RESTRICTED ANALOGUES OF GABA

1975 • 267 citations

The inhibitory action of noradrenaline and other monoamines on spinal neurones

1966 • 262 citations

Neurosteroid regulation of GABAA receptor single‐channel kinetic properties of mouse spinal cord neurons in culture.

1992 • 241 citations

Diazepam-Binding Inhibitor: A Neuropeptide Located in Selected Neuronal Populations of Rat Brain

1985 • 228 citations

Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons.

1993 • 223 citations

GABA_A receptors are differentially sensitive to zinc: dependence on subunit composition

1991 • 223 citations

Gaba agonists and antagonists

1979 • 222 citations

Noise analysis of miniature IPSCs in adult rat brain slices: properties and modulation of synaptic GABAA receptor channels

1994 • 222 citations

Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture.

1989 • 216 citations

Benzodiazepine and beta‐carboline regulation of single GABAA receptor channels of mouse spinal neurones in culture.

1994 • 214 citations

Neuropharmacology of Amino Acid Inhibitory Transmitters

1978 • 212 citations

Central actions of ibotenic acid and muscimol

1968 • 208 citations

Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

1992 • 203 citations

Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression.

1992 • 200 citations

Neurotransmitter-gated ion channels as unconventional allosteric proteins

1994 • 197 citations

Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

1993 • 194 citations

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1992 • 193 citations

Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties

1990 • 188 citations

Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore

1988 • 187 citations

Ethanol potentiation of GABA_A receptors requires phosphorylation of the alternatively spliced variant of the γ2 subunit

1992 • 178 citations

CIS‐ AND TRANS‐4‐AMINOCROTONIC ACID AS GABA ANALOGUES OF RESTRICTED CONFORMATION

1975 • 176 citations

Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.

1994 • 172 citations

Convulsive action of penicillin

1972 • 170 citations

Diazepam enhancement of low affinity GABA binding to rat brain membranes

1982 • 166 citations

Interleukin-1 augments gamma-aminobutyric acidA receptor function in brain.

1991 • 165 citations

Positive modulation of human gamma-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane.

1993 • 164 citations

Stoichiometry of a recombinant GABAA receptor deduced from mutation-induced rectification

1993 • 164 citations

Glucocorticoid Physiology, Pharmacology and Stress

1986 • 159 citations

Amino acids as chemical transmitters

1979 • 158 citations

Evidence that bicuculline and picrotoxin act at separate sites to antagonize γ-aminobutyric acid in rat cuneate nucleus

1980 • 158 citations

OCCLUSION AND METABOLISM OF γ‐AMINOBUTYRIC ACID BY BRAIN TISSUE*

1958 • 157 citations

Die Wirkung von Diazepam auf die pr�synaptische Hemmung und andere R�ckenmarksreflexe

1967 • 156 citations

Electrophysiological studies on the specific benzodiazepine antagonist Ro 15-1788

1981 • 156 citations

Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus

1976 • 155 citations

Emerging neurochemical concepts in the actions of ethanol at ligand-gated ion channels

1994 • 154 citations

Selective antagonist for the cerebellar granule cell-specific gamma-aminobutyric acid type A receptor.

1995 • 152 citations

Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism

1994 • 147 citations

Bicuculline Methochloride as a GABA Antagonist

1972 • 145 citations

ADVERSE REACTIONS TO INTRAVENOUS ANAESTHETICS: A Survey of 100 Reports

1975 • 145 citations

Multiple mechanisms of picrotoxin block of GABA‐induced currents in rat hippocampal neurons.

1993 • 144 citations

3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons.

1994 • 142 citations

Functional diversity of GABA activated Cl− currents in Purkinje versus granule neurons in rat cerebellar slices

1994 • 142 citations

Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?

1993 • 140 citations

Gamma‐aminobutyric acid uptake and the termination of inhibitory synaptic potentials in the rat hippocampal slice.

1985 • 139 citations

General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of intracellular calcium.

1992 • 139 citations

Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms

1985 • 136 citations

Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site

1986 • 134 citations

Estrogen regulation of GABAA receptor subunit mRNA expression in preoptic area and bed nucleus of the stria terminalis of female rat brain

1995 • 133 citations

A novel modulatory binding site for zinc on the GABAA receptor complex in cultured rat neurones.

1992 • 132 citations

Insecticide action at the GABA‐gated chloride channel: Recognition, progress, and prospects

1993 • 131 citations

Abecarnil, a metabolically stable, anxioselective beta-carboline acting at benzodiazepine receptors.

1990 • 130 citations

Analgesic properties of the GABA-minetic thip

1981 • 130 citations

Benzodiazepine and β-adrenergic receptor ligands independently stimulate phospholipid methylation

1979 • 128 citations

Role of GABAA receptors in the actions of alcohol and in alcoholism: recent advances.

1994 • 127 citations

The function of acyl-CoA-binding protein (ACBP)/Diazepam binding inhibitor (DBI)

1993 • 125 citations

Securinine alkaloids: A new class of GABA receptor antagonist

1985 • 121 citations

Potentiation of GABAA-mediated synaptic current by ethanol in hippocampal CA1 neurons: possible role of protein kinase C.

1994 • 117 citations

Rapid changes in GABA binding induced by stress in different areas of the rat brain

1981 • 115 citations

Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

1987 • 113 citations

Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae)

1994 • 112 citations

Differential effect of zinc on the vertebrate GABA_A‐receptor complex

1990 • 112 citations

The Role of Peptides and Amino Acids as Neurotransmitters

1982 • 111 citations

[³H]Bicuculline Methochloride Binding to Low‐Affinity γ‐Aminobutyric Acid Receptor Sites

1983 • 108 citations

Sodium and GABA-activated channels as the targets of pyrethroids and cyclodienes

1992 • 105 citations

Potentiation of GABA-mediated currents by cAMP-dependent protein kinase

1992 • 104 citations

Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogs of 6-(benzyloxy)-4-(methoxymethyl)-.beta.-carboline-3-carboxylic acid ethyl ester

1990 • 104 citations

Synthesis and structure-activity relationships of a series of aminopyridazine derivatives of .gamma.-aminobutyric acid acting as selective GABA-A antagonists

1987 • 104 citations

Pentobarbital: Stereospecific Actions of (+) and (-) Isomers Revealed on Cultured Mammalian Neurons

1980 • 104 citations

Anticonvulsant and anesthetic barbiturates

1979 • 104 citations

Taurine and β-alanine act on both GABA and glycine receptors in Xenopus oocyte injected with mouse brain messenger RNA

1988 • 102 citations

GABAA Receptor Agonists, Partial Agonists, and Antagonists. Design and Therapeutic Prospects

1994 • 102 citations

Penicillin and inhibition in the cat spinal cord

1972 • 99 citations

Structure-activity relationships in steroidal anaesthetics

1975 • 98 citations

Properties of gamma-aminobutyric acid receptor binding with (+)-[3H]bicuculline methiodide in rat cerebellum.

1978 • 93 citations

Chemical instability of the GABA antagonist bicuculline under physiological conditions

1975 • 89 citations

A steroid derivative, R 5135, antagonizes the GABA/benzodiazepine receptor interaction

1981 • 88 citations

Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat.

1988 • 87 citations

High affinity of the naturally-occurring biflavonoid, amentoflavon, to brain benzodiazepine receptors in vitro

1988 • 87 citations

Pharmacology of Barbiturates: Electrophysiological and Neurochemical Studies

1983 • 87 citations

Anaesthetic concentrations of alcohols potentiate GABAA receptor-mediated currents: lack of subunit specificity

1994 • 86 citations

Differential antagonism by epipregnanolone of alphaxalone and pregnanolone potentiation of [3H]flunitrazepam binding suggests more than one class of binding site for steroids at GABAA receptors

1993 • 85 citations

The rapidly expanding range of neuronal benzodiazepine receptor ligands

1993 • 84 citations

Steroid Modulation of the GABA _A Receptor Complex: Electrophysiological Studies

2007 • 83 citations

GABA agonists and antagonists

1992 • 83 citations

GABA ρ2 receptor pharmacological profile: GABA recognition site similarities to ρ1

1993 • 83 citations

Pharmacological receptors and general permeability phenomena of cell membranes

1965 • 82 citations

Prediction of Receptor Properties and Binding Affinity of Ligands to Benzodiazepine/GABAA Receptors Using Artificial Neural Networks

1995 • 81 citations

Multiple distinct subunits of the gamma-aminobutyric acid-A receptor protein show different ligand-binding affinities.

1990 • 81 citations

Increased GABA binding in mouse brain following acute swim stress

1981 • 81 citations

Glycine, strychnine, picrotoxin and spinal inhibition

1969 • 80 citations

Ethanol differentially modulates GABA_A receptor‐mediated chloride currents in hippocampal, cortical, and septal neurons in rat brain slices

1994 • 79 citations

The rat β₁ ‐subunit of the GABA_A receptor forms a picrotoxin‐sensitive anion channel open in the absence of GABA

1989 • 76 citations

The influence of estrus cycle on neurosteroid potency at the gamma-aminobutyric acidA receptor complex.

1993 • 76 citations

Spontaneous and GABA-evoked chloride channels on pituitary intermediate lobe cells and their internal Ca requirements

1987 • 76 citations

Brain γ-aminobutyric acid receptor binding is normal in rats with thioacetamide-induced hepatic encephalopathy despite elevated plasma γ-aminobutyric acid-like activity

1987 • 75 citations

Antagonist-type interaction of glucocorticoids with the GABA receptor-coupled chloride channel

1987 • 75 citations

γ‐AMINOBUTYRIC ACID AGONISTS: AN in vitro COMPARISON BETWEEN DEPRESSION OF SPINAL SYNAPTIC ACTIVITY AND DEPOLARIZATION OF SPINAL ROOT FIBRES IN THE RAT

1980 • 75 citations

Structure and molecular modeling of GABAA receptor antagonists

1992 • 75 citations

Current potentiation by diazepam but not GABA sensitivity is determined by a single histidine residue

1993 • 74 citations

Differential modulation of GABAA receptor-channel complex by polyvalent cations in rat dorsal root ganglion neurons

1993 • 74 citations

Antagonism of GABA_A receptors by 4-quinolones

1993 • 72 citations

Presence of a low molecular weight endogenous inhibitor on 3H-muscimol binding in synaptic membranes

1980 • 71 citations

Compounds from Danshen. Part 4. Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen)

1991 • 71 citations

Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor

1994 • 71 citations

Natural mutation of GABAA receptor α6 subunit alters benzodiazepine affinity but not allosteric GABA effects

1993 • 70 citations

Some properties of 3H-diazepam displacing activity from human urine

1979 • 70 citations

Benzodiazepine receptors and diazepam binding inhibitor: A possible link between stress, anxiety and the immune system

1993 • 69 citations

α subunits influence Zn block of γ2 containing GABAA receptor currents

1995 • 66 citations

Neuropoisons: Their Pathophysiological Actions

2012 • 66 citations

Assembly of GABAA receptor subunits determines sorting and localization in polarized cells

1993 • 65 citations

Dual activation of GABAA and glycine receptors by β-alanine: inverse modulation by progesterone and 5α-pregnan-3α-ol-20-one

1993 • 65 citations

Trichloroethanol potentiates synaptic transmission mediated by gamma-aminobutyric acidA receptors in hippocampal neurons.

1993 • 64 citations

Disruption of GABA-dependent chloride flux by cyclodienes and hexachlorocyclohexanes in primary cultures of cortical neurons.

1994 • 63 citations

Synthetic analogs for the study of GABA as a neurotransmitter

1983 • 63 citations

Pitrazepin, a novel GABAA antagonist

1984 • 63 citations

The effect of phospholipases and proteases on the binding of γ-aminobutyric acid to junctional complexes of rat cerebellum

1976 • 62 citations

Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia Miltiorrhiza

1991 • 61 citations

Volatile anesthetics bidirectionally and stereospecifically modulate ligand binding to GABA receptors

1994 • 61 citations

Differential pharmacological effects of benzodiazepine receptor inverse agonists.

1983 • 61 citations

The analgesic effect of the GABA‐agonist THIP in patients with chronic pain of malignant origin. A phase‐1‐2 study.

1983 • 60 citations

GABA Receptors and Phospholipids

1978 • 59 citations

Sex differences in the response of rats to drugs affecting GABAergic transmission

1985 • 59 citations

Kinetics of open channel block by penicillin of single GABAA receptor channels from mouse spinal cord neurones in culture.

1992 • 58 citations

Glycine and spinal inhibition

1967 • 58 citations

Antibodies Specific for α‐Subunit Subtypes of GABA_A Receptors Reveal Brain Regional Heterogeneity

1993 • 58 citations

Enhancement by anesthetic and convulsant barbiturates of GABA binding to rat brain synaptosomal membranes

1981 • 58 citations

Avermectin B_la Modulation of γ‐Aminobutyric Acid/Benzodiazepine Receptor Binding in Mammalian Brain

1985 • 58 citations

Activation of Calcium‐Phospholipid‐Dependent Protein Kinase Enhances Benzodiazepine and Barbiturate Potentiation of the GABA_A Receptor

1993 • 57 citations

Adrenalectomy Selectively Regulates GABAA Receptor Subunit Expression in the Hippocampus

1994 • 56 citations

Sex difference in response to alphaxalone anaesthesia may be oestrogen dependent

1982 • 56 citations

Effects of fenamates and other nonsteroidal anti-inflammatory drugs on rat brain GABAA receptors expressed in Xenopus oocytes.

1994 • 55 citations

GABA triggers a Cl− efflux from cultured mouse oligodendrocytes

1989 • 55 citations

Ethanol inhibits a neuronal ATP-gated ion channel.

1993 • 54 citations

[Effect of diazepam on presynaptic inhibition and other spinal reflexes].

1967 • 54 citations

Synthesis and Photochemistry of Photolabile Derivatives of .gamma.-Aminobutyric Acid for Chemical Kinetic Investigations of the .gamma.-Aminobutyric Acid Receptor in the Millisecond Time Region

1994 • 54 citations

Transamination of analogues of γ-aminobutyric acid by extracts of rat brain mitochondria

1973 • 54 citations

Actions of avermectin B_1a on the γ‐aminobutyric Acid_A receptor and chloride channels in rat brain

1986 • 53 citations

Benzodiazepine Suppression of Cortisol Secretion: A Measure of Anxiolytic Activity?

1986 • 53 citations

Ammonia potentiates GABAA response in dissociated rat cortical neurons

1993 • 52 citations

4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogs of THIP. Synthesis and biological activity

1983 • 52 citations

GABA?The quintessential neurotransmitter: Electroneutrality, fidelity, specificity, and a model for the ligand binding site of GABAA receptors

1993 • 51 citations

Etomidate potentiation of GABAA receptor gated current depends on the subunit composition

1995 • 51 citations

Thermodynamics of gamma-aminobutyric acid type A receptor binding differentiate agonists from antagonists.

1994 • 51 citations

THE PHYSIOLOGICAL ACTION OF CHOLESTEROL

1927 • 51 citations

Antagonism by penicillin of γ-aminobutyric acid depolarizations at presynaptic sites in rat olfactory cortex and cuneate nucleus in vitro

1980 • 51 citations

Sex and strain differences in GABA receptor binding after chronic ethanol drinking in mice

1980 • 50 citations

Muscimol and the uptake of ?-aminobutyric acid by rat brain slices

1971 • 50 citations

Neurochemical Studies on Quinolone Antibiotics: Effects on Glutamate, GABA and Adenosine Systems in Mammalian CNS

1989 • 49 citations

Pregnenolone—from selye to Alzheimer and a model of the pregnenolone sulfate binding site on the GABAA receptor

1995 • 48 citations

New developments on the search for the endogenous ligand(s) of central benzodiazepine receptors

1988 • 48 citations

GABA agonists. Resolution, absolute stereochemistry and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol

1985 • 47 citations

Bidirectional effects of benzodiazepine receptor ligands against picrotoxin- and pentylenetetrazol-induced seizures

1983 • 47 citations

Molecular Determinants of General Anesthetic Action: Role of GABA_A Receptor Structure

1993 • 46 citations

Currents Activated by GABA and their Modulation by Zn²⁺ in Cerebellar Granule Cells in Culture

1993 • 46 citations

Antagonism of inhibitory amino acids by the steroid derivative RU5135

1985 • 45 citations

Testosterone Enhances GABA and Taurine but not N‐Methyl‐D,L‐Aspartate Stimulation of Gonadotropin Secretion in the Goldfish: Possible Sex Steroid Feedback Mechanisms

1993 • 45 citations

Flavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extract.

1994 • 45 citations

Steroids and neuronal activity

1991 • 44 citations

Effects of 5-HT3 receptor antagonists on binding and function of mouse and human GABAA receptors

1994 • 44 citations

Functional Heterogeneity of Hippocampal GABA_A Receptors

1993 • 44 citations

Phospholipid Methylation Increases [³H]Diazepam and [³H]GABA Binding in Membrane Preparations of Rat Cerebellum

1983 • 43 citations

Effects of Antiepileptic Drugs on GABA Responses and on Reduction of GABA Responses by PTZ and DMCM on Mouse Neurons in Cell Culture

1989 • 43 citations

Sex Differences in the Effects of Acute Swim Stress on Binding to GABA_A Receptors in Mouse Brain

1993 • 43 citations

Electrophysiological studies of the GABA_A receptor ligand, 4‐PIOL, on cultured hippocampal neurones

1991 • 42 citations

Neurosteroid analogs: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles

1993 • 42 citations

Gamma-aminobutyric acidA receptor function is inhibited by microtubule depolymerization.

1994 • 40 citations

Interactions between three pyridazinyl-GABA derivatives and central GABA and glycine receptors in the rat, an in vivo microiontophoretic study

1986 • 39 citations

Phospholipids and benzodiazepine recognition sites of brain synaptic membranes

1981 • 38 citations

Bidirectional Modulation of GABA‐Gated Chloride Channels by Divalent Cations: Inhibition by Ca²⁺ and Enhancement by Mg²⁺

1994 • 38 citations

Convulsant doses of penicillin shorten the lifetime of GABA‐induced channels in cultured central neurones

1986 • 38 citations

Purines interact with ‘central’ but not ‘peripheral’ benzodiazepine binding sites

1982 • 37 citations

Cortisol: A potent biphasic modulator at GABAA-receptor complexes in the guinea pig isolated ileum

1987 • 37 citations

.alpha.-Spirocyclopentyl- and .alpha.-spirocyclopropyl-.gamma.-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant .alpha.,.alpha.-disubstituted .gamma.-butyrolactones

1994 • 36 citations

Selective effects of dieldrin on the GABAA receptor-channel subunits expressed in human embryonic kidney cells

1994 • 36 citations

Ovarian steroid modulation of [3H]muscimol binding in the spinal cord of the rat

1991 • 35 citations

Pharmacology of Neurosteroid Biosynthesis. Role of the Mitochondrial DBI Receptor (MDR) Complex

1994 • 35 citations

Time course of GABA and glycine actions on cat spinal neurones: Effect of pentobarbitone

1978 • 35 citations

Selective potentiation of GABA-mediated Cl− current by lanthanum ion in subtypes of cloned GABAA receptors

1992 • 34 citations

Stress — the neglected variable in experimental pharmacology and toxicology

1987 • 34 citations

Characterization of GAVAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes

1987 • 34 citations

DL-Tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy

1992 • 34 citations

(+)‐Hydrastine, a potent competitive antagonist at mammalian GABA_A receptors

1990 • 33 citations

Evidence for association of a high affinity avermectin binding site with the benzodiazepine receptor

1984 • 33 citations

CoMFA validation of the superposition of six classes of compounds which block GABA receptors non-competitively

1993 • 33 citations

GABA‐Mimetic Activity and Effects on Diazepam Binding of Aminosulphonic Acids Structurally Related to Piperidine‐4‐Sulphonic Acid

1985 • 33 citations

Effects of diuretics on GABA‐gated chloride current in frog isolated sensory neurones

1988 • 32 citations

Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions

1986 • 31 citations

Isothiouronium compounds as γ‐aminobutyric acid agonists

1986 • 31 citations

The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission

1987 • 31 citations

Functional changes in GABAA receptor stimulation during the oestrous cycle of the rat

1991 • 30 citations

Differences in the interactions between GABA and benzodiazepine binding sites

1982 • 30 citations

Liposome‐entrapped GABA modifies behavioral and electrographic changes of penicillin‐induced epileptic activity

1982 • 30 citations

Purine inhibition of [3H]-γ-aminobutyric acid receptor binding to rat brain membranes

1980 • 30 citations

Regulation of gaba receptor binding to synaptic plasma membrane of rat cerebral cortex: The role of endogenous phospholipids

1981 • 29 citations

Comparison of the analgesic actions of THIP and morphine

1983 • 29 citations

A comparison of the actions of pentobarbitone and etomidate on [3H]GABA binding to crude synaptosomal rat brain membranes

1981 • 29 citations

Bicuculline blocks nicotinic acetylcholine response in isolated intermediate lobe cells of the pig

1991 • 29 citations

GABA‐A agonists and GABA uptake inhibitors: Structure‐activity relationships

1990 • 29 citations

The GABA_A receptor channel mediated chloride ion translocation through the plasma membrane: New insights from ³⁶Cl⁻ ion flux measurements

1993 • 29 citations

Pyridazinyl-GABA derivatives as GABA and glycine antagonists in the spinal cord of the cat

1986 • 29 citations

Bromide, in the therapeutic concentration, enhances GABA-activated currents in cultured neurons of rat cerebral cortex

1994 • 28 citations

The effects of anaesthetic and convulsant barbiturates on the efflux of [3H]d-aspartate from brain minislices

1980 • 28 citations

Inhibition of Glutamate Release by Arachidonic Acid in Rat Cerebrocortical Synaptosomes

1991 • 28 citations

Inhibition of acetylcholinesterase by bicuculline and related alkaloids

1975 • 28 citations

Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.

1990 • 28 citations

Neonatal stress and long-term modulation of GABA receptors in rat brain

1990 • 27 citations

γ-Aminobutyric acid receptor binding antagonism by the amidine steroid RU5135

1984 • 27 citations

Taurine allosterically modulates flunitrazepam binding to synaptic membranes

1992 • 27 citations

Sex differences in GABAA receptor binding in rat brain measured by an improved in vitro binding assay

1990 • 27 citations

Voltage-dependent modulation of GABAA receptor channel desensitization in rat hippocampal neurons

1994 • 27 citations

Glycine antagonism by RU 5135

1985 • 26 citations

Comparative Photoaffinity Labeling Study between Azidophenyl, Difluoroazidophenyl, and Tetrafluoroazidophenyl Derivatives for the GABA-Gated Chloride Channels

1995 • 26 citations

Activation of Cl? channels by avermectin in rat cultured hippocampal neurons

1993 • 26 citations

Diazotization and Thiocyanate Differentiate Agonists from Antagonists for the High‐ and Low‐Affinity Receptors of γ‐Aminobutyric Acid

1984 • 26 citations

Pentobarbitone slows the dissociation of GABA from rat brain synaptosomal binding sites

1981 • 25 citations

Contrasting regulation by GABA of the displacement of benzodiazepine antagonist binding by benzodiazepine agonists and purines

1982 • 25 citations

Mono N-Aryl ethylenediamine and piperazine derivatives are GABAA receptor blockers: Implications for psychiatry

1993 • 25 citations

Inhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofulein.

1994 • 24 citations

On the GABA_A receptor: A molecular modeling approach

1989 • 24 citations

Influence of membrane potential on conductance sublevels of chloride channels activated by GABA

1994 • 24 citations

Effects of Amitriptyline on GABA-stimulated 36Cl− uptake in relation to a behavioral model of depression

1995 • 24 citations

GABA RECEPTORS: AS COMPLEX AS ABC?

1994 • 24 citations

Synthesis of Analogues of GABA. III. All Four Stereoisomers of 3-Aminocyclopentanecarboxylic Acid and a Stereochemical Correlation with Amidinomycin

1979 • 24 citations

δ-Guanidinovaleric acid as an endogenous and specific GABA-receptor antagonist: electroencephalographic study

1987 • 23 citations

Effects of taurine on cell morphology and expression of low-affinity GABA receptors in cultured cerebellar granule cells

1989 • 23 citations

Effects of 5-hydroxytryptamine on central neurones antagonized by bicuculline and picrotoxin

1981 • 23 citations

Diazepam stimulates the binding of GABA and muscimol but not thip to rat brain membranes

1983 • 23 citations

Modulatory action of arachidonic acid on GABAA/chloride channel receptor function in adult and aged brain cortex membranes

1993 • 23 citations

Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist.

1991 • 23 citations

Endogenous inhibitors of picrotoxinin-convulsant binding sites in rat brain

1980 • 22 citations

Modification of responses to sensory and hippocampal stimuli in neurons of the rat mediobasal hypothalamus in the presence of iontophoretically applied cortisol

1981 • 22 citations

Alkyl-substituted γ-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex

1993 • 21 citations

Water-soluble steroidal anaesthetics

1979 • 21 citations

γ‐Aminobutyric Acid Receptor Ionophore Complexes: Differential Effects of Deltamethrin, Dichlorodiphenyltrichloroethane, and Some Novel Insecticides in a Rat Brain Membrane Preparation

1987 • 20 citations

Activation of γ‐aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B_1a

1991 • 20 citations

Corticosteroid receptors and the central nervous system

1994 • 20 citations

Benzodiazepines and barbiturate potentiate the pre- and postsynaptic gamma-aminobutyric acid (GABA)A receptor-mediated response in the enteric nervous system of guinea pig small intestine.

1988 • 19 citations

Brain Region-Specific Effects of Neuroactive Steroids on the Affinity and Density of the GABA-Binding Site

1993 • 19 citations

Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors

1985 • 19 citations

Reductions in blood pressure, heart rate and renal sympathetic nervous discharge after imidazole-4-acetic acid: mediation through central gamma-aminobutyric acid (GABA) receptor stimulation.

1981 • 18 citations

Indomethacin/ibuprofen-like anti-inflammatory agents selectively potentiate the gamma-aminobutyric acid-antagonistic effects of several norfloxacin-like quinolone antibacterial agents on [35S]t-butylbicyclophosphorothionate binding.

1993 • 18 citations

Synthesis and pharmacological characterization of l-trans-4-tetrazolylproline (ly300020): A novel systemically-active ampa receptor agonist

1993 • 18 citations

Cortisone: a potent GABAA antagonist in the guinea-pig isolated ileum

1990 • 18 citations

Beware the builders: Construction noise changes [14C]GABA release and uptake from amygdaloid and hippocampal slices in the rat

1993 • 18 citations

Modulation of [3H]flunitrazepam binding to rat cerebellar benzodiazepine receptors by phosphatidylserine

1987 • 17 citations

Pregnenolone and its sulphate modulate GABAA-receptor-mediated contractile responses in the guinea-pig isolated ileum

1987 • 17 citations

Increased γ‐Aminobutyric Acid Receptor Function in the Cerebral Cortex of Myoclonic Calves with an Hereditary Deficit in Glycine/Strychnine Receptors

1990 • 17 citations

Direct excitant action of convulsant barbiturates

1981 • 17 citations

Actions of pentobarbitone and derivatives with modified 5-butyl substituents on GABA and diazepam binding to rat brain synaptosomal membranes

1983 • 16 citations

GABA activated chloride currents in cultured rat hippocampal and septal region neurons can be inhibited by curare and atropine

1988 • 16 citations

Radioautographic Evidence that the GABA_A Receptor Antagonist SR 95531 is a Substrate Inhibitor of MAO‐A in the Rat and Human Locus Coeruleus

1994 • 16 citations

Novel arylaminopyridazine-GABA receptor antagonists examined electrophysiologically in Ascaris suum

1995 • 16 citations

Effects of cortisol on GABAA receptor-mediated responses compared in guinea-pig ileum and rat cuneate nucleus

1989 • 16 citations

Benzodiazepines and steroidogenesis

1992 • 16 citations

Picrodendrins, a New Group of Picrotoxane Terpenoids: Structure-Activity Profile of Action at the GABA_AReceptor-coupled Picrotoxinin Binding Site in Rat Brain

1994 • 15 citations

Ligand Structural Specificity of GABA_A Receptors in Guinea Pig Ileum

1991 • 15 citations

GABA_<scp>a</scp> AGONISTS AS TARGETS FOR DRUG DEVELOPMENT

1992 • 14 citations

ZAPA, (Z)‐3‐[(aminoiminomethyl)thio]‐2‐propenoic acid hydrochloride, a potent agonist at GABA‐receptors on the Ascaris muscle cell

1988 • 14 citations

The bicuculline - like properties of dopamine sulfate in rat brain

1984 • 13 citations

Interaction of La3+ with GABAA receptors in rat cerebrocortical membranes as detected with [35S]t-butylbicyclophosphorothionate binding

1993 • 13 citations

Thiomuscimol, a new photoaffinity label for the GABAA receptor

1995 • 13 citations

Diazepam enhances the action but not the binding of the GABA analog, THIP

1984 • 13 citations

Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.

1984 • 13 citations

Penicillin‐induced potentiation of glycine receptor‐operated choride current in rat ventro‐medial hypothalamic neurones

1992 • 12 citations

Modulation of the GABAA-like autoreceptor by barbiturates but not by steroids

1993 • 11 citations

Zur Physiologie und Pharmakologie der Sterine

1936 • 11 citations

Amino acid antagonists and the depression of cuneate neurones by -aminobutyric acid (GABA) and glycine.

1973 • 11 citations

Astroglia‐released factor shows similar effects as benzodiazepine inverse agonists

1994 • 11 citations

Methods for removing endogenous factors from CNS membrane preparations: Differences in [3H]GABA binding parameters and developmental-related effects

1993 • 10 citations

Barbiturates and calcium-activated adenosine triphosphatase

1979 • 10 citations

m‐Sulfonate Benzene Diazonium Chloride: A Powerful Affinity Label for the γ‐Aminobutyric Acid Binding Site from Rat Brain

1992 • 10 citations

U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.

1993 • 10 citations

ZAPA, a substrate for the neuronal high affinity GABA uptake system in rat brain slices

1991 • 10 citations

Strychnine-insensitive glycine binding to cerebral cortical membranes in developing and ageing mice

1993 • 10 citations

Inhibition of GABAA receptor-mediated current responses by enoxacin (new quinolone) and felbinac (non-steroidal anti-inflammatory drug) in Xenopus oocytes injected with mouse-brain messenger RNA.

1993 • 9 citations

Selective blockade of benzodiazepine receptors by Ro 15-1788 prevents foot shock-induced decrease of low affinity γ-aminobutyric acid receptors

1985 • 9 citations

2-Imino-1,3,4-thiadiazole Derivatives of GABA as GABAA Antagonists

1990 • 9 citations

Pitrazepin: a central glycine and GABA antagonist

1986 • 9 citations

Synergistic effect of phosphatidylserine with ?-aminobutyric acid in antagonizing the isoniazid-induced convulsions in mice

1984 • 9 citations

Electrophysiological and metabolic effects of a convulsant barbiturate on dissociated mouse primary sensory neurons.

1995 • 8 citations

Benzodiazepine Receptor Ligands with Positive and Negative Efficacy

1984 • 8 citations

Convulsant effects of cunaniol, a polyacetylenic alcohol isolated from the plant Clibadium sylvestre, on frogs and mice

1969 • 8 citations

An antinociceptive profile of kojic amine: An analogue of γ-aminobutyric acid (GABA)

1987 • 8 citations

Gamma-aminobutyric acidA receptor function is modulated by cyclic GMP

1995 • 8 citations

Isolation of endogenous modulators for the GABAA and taurine receptors

1993 • 7 citations

Does bicuculline antagonize NMDA receptors? Further evidence in the rat striatum

1994 • 7 citations

Effects of gamma-aminobutyric acid on the compound action potential of the rat superior cervical ganglion.

1993 • 7 citations

Sodium-Independent, High-Affinity Binding of [3H]γ-Aminobutyric Acid in Human Neurological Disorders

1979 • 7 citations

In Vivo Formation of Benzodiazepine-like Molecules in Mammalian Brain

1993 • 6 citations

Bis(2-chloroalkyl)amides of Acylated Amino Acids. Modified Nitrogen Mustards¹

1965 • 5 citations

Cannabinoid metabolite interacts with benzodiazepine receptor

1992 • 5 citations

Structural factors governing agonist and antagonist activity in the GABAA system

1988 • 5 citations

Penicilin-induced triphasic modulation of GABAA receptor-operated chloride current in frog sensory neuron

1992 • 5 citations

Caprolactam-barbiturate interaction at the GABAA receptor complex in the guinea-pig intestine

1986 • 5 citations

Differential modulation of γ-aminobutyric acid receptors by caprolactam derivatives with central nervous system depressant on convulsant activity

1985 • 5 citations

Synthesis of Substituted (+)-Bicuculline Derivatives Through Chloromethylation

1990 • 5 citations

m-Sulphonate benzene diazonium chloride: A novel GABAA receptor antagonist

1994 • 4 citations

Effects of a depressant/convulsant pair of glutarimides on neuronal activity in the isolated spinal cord of the immature rat

1985 • 3 citations

The synthesis of 1,8-disubstituted 10,11-dihydrodibenz[b,f]oxepin-10-ones. analogues of anaesthetic steroids

1991 • 3 citations

Formation of γ‐Amino‐β‐Hydroxybutyric Acid from 2‐Hydroxyputrescine in Rat Brain

1988 • 3 citations

Effect of phosphatidylserine on the basal and GABA-activated Cl? permeation across single nerve membranes from rabbit Deiters' neurons

1990 • 2 citations

Esters of 6‐(4′‐fluorobenzylamino)‐β‐ carboline‐3‐carboxylic acid as potential benzodiazepine imaging agents for P.E.T.

1995 • 1 citations