Curcumin inhibits protease-activated receptor-2 and -4-mediated mast cell activation

Mast cells

1997 • 1,636 citations

Proteinase-activated Receptors

2006 • 1,166 citations

Cloning and characterization of human protease-activated receptor 4

1998 • 807 citations

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1996 • 457 citations

Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin

1998 • 399 citations

Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2

2002 • 377 citations

Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells

2001 • 371 citations

Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IκB kinase and NFκB activation in macrophages

2000 • 356 citations

Molecular Cloning and Functional Expression of the Gene Encoding the Human Proteinase‐Activated Receptor 2

1995 • 334 citations

Delayed Onset of Inflammation in Protease-Activated Receptor-2-Deficient Mice

2000 • 277 citations

Curcumin prevents and ameliorates trinitrobenzene sulfonic acid–induced colitis in mice

2002 • 255 citations

Curcumin (Diferuloylmethane) Inhibition of Tumor Necrosis Factor (TNF)-Mediated Adhesion of Monocytes to Endothelial Cells by Suppression of Cell Surface Expression of Adhesion Molecules and of Nuclear Factor-κB Activation

1998 • 243 citations

Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.

1990 • 236 citations

Human lung tryptase. Purification and characterization.

1984 • 172 citations

Mast cell tumor necrosis factor α production is regulated by MEK kinases

1997 • 152 citations

PROTEINASE-ACTIVATED RECEPTORS

2006 • 149 citations

Release of Mast Cell Tryptase from Human Colorectal Mucosa in Inflammatory Bowel Disease

2001 • 140 citations

Tryptase Activates the Mitogen-Activated Protein Kinase/Activator Protein-1 Pathway in Human Peripheral Blood Eosinophils, Causing Cytokine Production and Release

2002 • 122 citations

Increased vascular permeability by a specific agonist of protease‐activated receptor‐2 in rat hindpaw

1998 • 120 citations

Mast cells and inflammatory mediators in chronic ulcerative colitis

2002 • 117 citations

p38 MAP KINASE REGULATES TNF-α PRODUCTION IN HUMAN ASTROCYTES AND MICROGLIA BY MULTIPLE MECHANISMS

2000 • 112 citations

Expression of Protease-Activated Receptor 2 in Ulcerative Colitis

2003 • 92 citations

Treatment of mildly to moderately active ulcerative colitis with a tryptase inhibitor (APC 2059): an open‐label pilot study

2002 • 85 citations

Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient Ws/Ws rats

2000 • 78 citations

Trypsin Stimulates Production of Cytokines from Peritoneal Macrophages In Vitro and In Vivo

2000 • 66 citations

Trypsin induces tumour necrosis factor‐α secretion from a human leukemic mast cell line

2003 • 25 citations

Murine monoclonal anti-tNF antibody administration has a beneficial effect on inflammatory bowel disease that develops in IL-10 knockout mice.

2002 • 24 citations

Proteinase-Activated Receptor-4 is implicated in the pathogenesis of Dextran Sodium Sulfate colitis

2003 • 7 citations