Increased vascular permeability by a specific agonist of protease‐activated receptor‐2 in rat hindpaw

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

1991 • 2,981 citations

Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine

1971 • 1,433 citations

Molecular cloning of a potential proteinase activated receptor.

1994 • 887 citations

Protease-activated receptor 3 is a second thrombin receptor in humans

1997 • 878 citations

Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

1997 • 592 citations

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

1996 • 457 citations

The Proteinase-activated Receptor 2 Is Induced by Inflammatory Mediators in Human Endothelial Cells

1996 • 352 citations

Thrombin functions as an inflammatory mediator through activation of its receptor.

1996 • 260 citations

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1997 • 240 citations

Ligand Cross-reactivity within the Protease-activated Receptor Family

1996 • 210 citations

Thrombin-induced degranulation of cultured bone marrow-derived mast cells.

1984 • 97 citations

Thrombin-Mediated Increase in Vascular Endothelial Permeability

1992 • 97 citations

Proteinase-activated receptor-2 in rat aorta: structural requirements for agonist activity of receptor-activating peptides.

1996 • 94 citations

Vascular actions of thrombin receptor peptide

1992 • 91 citations

[6] Tryptase: A mast cell serine protease

1994 • 90 citations

Protease-mediated signalling: new paradigms for cell regulation and drug development

1996 • 79 citations

Identification of potential activators of proteinase‐activated receptor‐2¹

1997 • 66 citations

Dual endothelium‐dependent vascular activities of proteinase‐activated receptor‐2‐activating peptides: evidence for receptor heterogeneity

1998 • 57 citations

Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2).

1997 • 18 citations