Characterization of Group X Phospholipase A2 as the Major Enzyme Secreted by Human Keratinocytes and its Regulation by the Phorbol Ester TPA

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Human stratum corneum lipids: characterization and regional variations

1983 • 664 citations

REGULATION AND INHIBITION OF PHOSPHOLIPASE A₂

1999 • 574 citations

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

1998 • 369 citations

Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites

2000 • 292 citations

A Reassessment of the Low Molecular Weight Phospholipase A2 Gene Family in Mammals

1997 • 284 citations

Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages

1996 • 259 citations

Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2

1997 • 256 citations

Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2

1995 • 216 citations

Exogenously Added Human Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes Efficiently Release Arachidonic Acid from Adherent Mammalian Cells

2000 • 209 citations

Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

1993 • 206 citations

The Interleukin 1 Receptor: Ligand Interactions and Signal Transduction

1998 • 178 citations

Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2

1999 • 176 citations

Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.

1996 • 172 citations

Localization of Nonpancreatic Secretory Phospholipase A ₂ in Normal and Atherosclerotic Arteries

1997 • 169 citations

Structures, Enzymatic Properties, and Expression of Novel Human and Mouse Secretory Phospholipase A2s

2000 • 165 citations

Analysis of the Secretory Phospholipase A2 That Mediates Prostaglandin Production in Mast Cells

1997 • 164 citations

Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells

1999 • 163 citations

Different Functional Aspects of the Group II Subfamily (Types IIA and V) and Type X Secretory Phospholipase A2s in Regulating Arachidonic Acid Release and Prostaglandin Generation

1999 • 159 citations

Regulation of Delayed Prostaglandin Production in Activated P388D1 Macrophages by Group IV Cytosolic and Group V Secretory Phospholipase A2s

1999 • 154 citations

Cloning and Characterization of Novel Mouse and Human Secretory Phospholipase A2s

1999 • 141 citations

Secretory Phospholipase A2 Activity Is Required for Permeability Barrier Homeostasis

1996 • 117 citations

Induction of Inducible Nitric Oxide Synthase and its Corresponding Tetrahydrobiopterin-Cofactor-Synthesizing Enzyme GTP-Cyclohydrolase I During Cutaneous Wound Repair

1998 • 115 citations

A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate–induced invasion in mouse keratinocytes

1997 • 113 citations

Extracellular processing of phospholipids is required for permeability barrier homeostasis.

1995 • 113 citations

Cloning and Recombinant Expression of a Novel Mouse-secreted Phospholipase A2

1999 • 113 citations

Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-kappa B and expression of ICAM-1.

1998 • 112 citations

Selective Inhibitors of Cytosolic or Secretory Phospholipase A2 Block TNF-Induced Activation of Transcription Factor Nuclear Factor-κB and Expression of ICAM-1

1998 • 89 citations

Regulation of type V phospholipase A₂ expression and function by proinflammatory stimuli

1999 • 89 citations

Elevated expression of human nonpancreatic phospholipase A2 in psoriatic tissue

1994 • 81 citations

Expression and characterization of human group V phospholipase A2

1998 • 81 citations

AP-1 and Ets Transcription Factors Regulate the Expression of the Human SPRR1A Keratinocyte Terminal Differentiation Marker

1998 • 78 citations

Inflammatory Effect of Intradermal Administration of Soluble Phospholipase A2 in Rabbits

1986 • 68 citations

Mesangial Cells Orchestrate Inflammation in the Renal Glomerulus

1994 • 66 citations

Regulation of the cellular expression of secretory and cytosolic phospholipases A2, and cyclooxygenase-2 by peptide growth factors

1998 • 65 citations

Low Molecular Weight Group IIA and Group V Phospholipase A2 Enzymes Have Different Intracellular Locations in Mouse Bone Marrow-derived Mast Cells

1999 • 64 citations

Differential expression of prostaglandin-H synthase isoenzymes in normal and activated keratinocytes in vivo and in vitro

1995 • 63 citations

Retinoids Downregulate Vascular Endothelial Growth Factor/Vascular Permeability Factor Production by Normal Human Keratinocytes

1998 • 60 citations

cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin

1998 • 59 citations

Increased expression of human type IIa secretory phospholipase A2 antigen in arthritic synovium

1998 • 54 citations

Analysis of secretory group II phospholipase A2 expression in human aortic tissue in dependence on the degree of atherosclerosis

1999 • 50 citations

The conversion stage of skin carcinogenesis

1990 • 49 citations

Coordinate expression of secretory phospholipase A₂ and cyclooxygenase-2 in activated human keratinocytes

2000 • 43 citations

Localization of Prostaglandin-H Synthase-1 and -2 in Mouse Skin: Implications for Cutaneous Function

1998 • 40 citations

Localization of group IIc low molecular weight phospholipase A2 mRNA to meiotic cells in the mouse

1997 • 38 citations

Phospholipase A2

1997 • 36 citations

Epidermal Enzymes: Their Role in Homeostasis and Their Relationships with Dermatoses

1998 • 36 citations

The up-regulation of vascular endothelial growth factor in mutated Ha-ras HaCaT cell lines is reduced by a farnesyl transferase inhibitor.

1999 • 36 citations

Phorbol Ester TPA- and Bradykinin-Induced Arachidonic Acid Release from Keratinocytes Is Catalyzed by a Cytosolic Phospholipase A2(cPLA2)

1993 • 35 citations

Secretory low-molecular-weight phospholipases A2 and their specific receptor in bile ducts of patients with intrahepatic calculi: Factors of chronic proliferative cholangitis

1999 • 35 citations

Identification of pancreatic type I secreted phospholipase A2 in human epidermis and its determination by tape stripping

2000 • 33 citations

Enzymatic properties of rat group IIA and V phospholipases A2 compared

1999 • 28 citations

Negative regulation of interleukin‐1β‐activated neutral sphingomyelinase by protein kinase C in rat mesangial cells

1998 • 27 citations

Measurement of anti-inflammatory effects of glucocorticoids on human keratinocytes in vitro. Comparison of normal human keratinocytes with the keratinocyte cell line HaCaT.

1997 • 26 citations

Levels and localization of group II phospholipase A2 and annexin I in interleukin- and dexamethasone-treated rat mesangial cells: evidence against annexin mediation of the dexamethasone-induced inhibition of group II phospholipases A2

1994 • 26 citations

Transforming Growth Factor–α Induces Interleukin-6 in the Human Keratinocyte Cell Line HaCaT Mainly by Transcriptional Activation

1996 • 24 citations

Swine as a model of skin inflammation

1993 • 23 citations

Distribution of immunoreactive pancreatic phospholipase A2 (IPPL-2) in various human tissues.

1987 • 19 citations

Suppression or elevation of cytosolic phospholipase A2 alters keratinocyte prostaglandin synthesis, growth, and apoptosis.

1998 • 18 citations

Identification of Two Secreted Phospholipases A2 in Human Epidermis

2000 • 18 citations

Control of Phospholipase A<sup>2</sup> Gene Expression

1997 • 10 citations

Modulation of cytokine-induced expression of secretory phospholipase A2-type IIA by protein kinase C in rat renal mesangial cells

1999 • 10 citations