Identification of Two Secreted Phospholipases A2 in Human Epidermis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

The growing phospholipase A2 superfamily of signal transduction enzymes

1997 • 811 citations

The role of phosphatidylserine in recognition of apoptotic cells by phagocytes

1998 • 724 citations

REGULATION AND INHIBITION OF PHOSPHOLIPASE A₂

1999 • 574 citations

Regulatory Functions of Phospholipase A2

1997 • 551 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Cloning and Recombinant Expression of Phospholipase A2 Present in Rheumatoid Arthritic Synovial Fluid

1989 • 542 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

1991 • 413 citations

Percutaneous Transport in Relation to Stratum Corneum Structure and Lipid Composition

1981 • 321 citations

The apoptosis cascade -- morphological and immunohistochemical methods for its visualization

1999 • 316 citations

A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs

1997 • 302 citations

Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization.

1994 • 264 citations

Terminal Epidermal Differentiation of Human Keratinocytes Grown in Chemically Defined Medium on Inert Filter Substrates at the Air-Liquid Interface

1990 • 263 citations

Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2

1997 • 256 citations

Extracellular phospholipase A2 expression and inflammation: the relationship with associated disease states.

1993 • 236 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

Pancreatic Phospholipase A₂: Isolation of the Human Gene and cDNAs from Porcine Pancreas and Human Lung

1986 • 225 citations

Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes.

1995 • 223 citations

Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase.

1994 • 210 citations

Caspase activation in the terminal differentiation of human epidermal keratinocytes

1999 • 196 citations

Structure-function relationships of phospholipases. The anticoagulant region of phospholipases A2.

1987 • 176 citations

Identification of Phosphorylation Sites of Human 85-kDa Cytosolic Phospholipase A2 Expressed in Insect Cells and Present in Human Monocytes

1996 • 165 citations

Characterization of phospholipase A2 (PLA2) activity in gerbil brain: enhanced activities of cytosolic, mitochondrial, and microsomal forms after ischemia and reperfusion

1991 • 151 citations

Lipid Composition and Acid Hydrolase Content of Lamellar Granules of Fetal Rat Epidermis

1985 • 149 citations

Stratum corneum architecture, metabolic activity and interactivity with subjacent cell layers

1996 • 132 citations

Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1.

1988 • 128 citations

A phospholipase A2 in the supernatant fraction of rat spleen. Its similarity to rat pancreatic phospholipase A2.

1988 • 118 citations

Secretory Phospholipase A2 Activity Is Required for Permeability Barrier Homeostasis

1996 • 117 citations

Extracellular processing of phospholipids is required for permeability barrier homeostasis.

1995 • 113 citations

Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion

1996 • 100 citations

Interfacial activation, lysophospholipase and transacylase activity of Group VI Ca2+-independent phospholipase A2

1998 • 94 citations

Characterization and activity of phospholipase A2 in normal human epidermis and in lesion-free epidermis of patients with psoriasis or eczema

1985 • 93 citations

High specificity of human secretory class II phospholipase A2 for phosphatidic acid

1997 • 90 citations

Distribution of pancreatic (group I) and synovial-type (group II) phospholipases A2 in human tissues

1993 • 90 citations

Elevated expression of human nonpancreatic phospholipase A2 in psoriatic tissue

1994 • 81 citations

The level of phospholipase A2 activity is raised in the uninvolved epidermis of psoriasis

1983 • 72 citations

Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia.

1994 • 72 citations

Growth and differentiation of normal human melanocytes in a TPA-free, cholera toxin-free, low-serum medium and influence of keratinocytes

1993 • 69 citations

Enhanced keratinocyte prostaglandin synthesis after UV injury is due to increased phospholipase activity

1993 • 64 citations

Variations in Lipids in Different Layers of Porcine Epidermis

1986 • 59 citations

Expression of group-II phospholipase A2 in malignant and non-malignant human gastric mucosa

1993 • 56 citations

Effect of pancreatic type phospholipase A₂ on isolated porcine cerebral arteries via its specific binding sites

1992 • 54 citations

Extracellular phospholipase A2: causative agent in circulatory collapse of septic shock?

1988 • 46 citations

Epidermal Enzymes: Their Role in Homeostasis and Their Relationships with Dermatoses

1998 • 36 citations

Identification of pancreatic type I secreted phospholipase A2 in human epidermis and its determination by tape stripping

2000 • 33 citations

Identification and characterization of several forms of phospholipase A2 in mouse epidermal keratinocytes

1998 • 27 citations

The role of phospholipase A2 in the physiopathology of osteoarthritis.

1991 • 21 citations

Soluble Phospholipase A2 in Human Pathology: Clinical-Laboratory Interface

1990 • 20 citations

A new approach to the measurement of phospholipase A2 in tissue homogenates and its application to human skin

1986 • 16 citations

Ca2+-Independent Phospholipase A2 Is Required for α2-Adrenergic-Induced Preadipocyte Spreading

1999 • 15 citations

30‐kDa Trypsin‐like Proteases in the Plantar Stratum Corneum

1997 • 10 citations

Phospholipase A2 is secreted by murine keratinocytes after stimulation with IL-1α and TNF-α

1996 • 9 citations

Expression of Two cPLA2 Isoforms in Mouse Epidermis in Vivo

1997 • 4 citations

Differential Activation of Keratinocyte Phospholipase A2S by Tumor Promoters and other Irritants

1997 • 1 citations