Different Functional Aspects of the Group II Subfamily (Types IIA and V) and Type X Secretory Phospholipase A2s in Regulating Arachidonic Acid Release and Prostaglandin Generation

Microdetermination of Long-chain Fatty Acids in Plasma and Tissues

1960 • 2,233 citations

Properties and Regulation of Cytosolic Phospholipase A2

1997 • 814 citations

The growing phospholipase A2 superfamily of signal transduction enzymes

1997 • 811 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Regulatory Functions of Phospholipase A2

1997 • 551 citations

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

1995 • 529 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Inhibition of Macrophage Ca2+-independent Phospholipase A2 by Bromoenol Lactone and Trifluoromethyl Ketones

1995 • 401 citations

Molecular Cloning of Human Plasma Membrane Phospholipid Scramblase

1997 • 389 citations

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

1998 • 369 citations

Mammalian non-pancreatic phospholipases A2

1993 • 355 citations

Functional Coupling Between Various Phospholipase A2s and Cyclooxygenases in Immediate and Delayed Prostanoid Biosynthetic Pathways

1999 • 350 citations

Function and Inhibition of Intracellular Calcium-independent Phospholipase A2

1997 • 306 citations

Peroxisome Proliferators Enhance Cyclooxygenase-2 Expression in Epithelial Cells

1999 • 298 citations

A Reassessment of the Low Molecular Weight Phospholipase A2 Gene Family in Mammals

1997 • 284 citations

Cloning and expression of a membrane receptor for secretory phospholipases A2.

1994 • 278 citations

Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages

1996 • 259 citations

Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2

1997 • 256 citations

Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2.

1994 • 224 citations

Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells.

1994 • 219 citations

Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2

1995 • 216 citations

Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2.

1993 • 210 citations

Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

1993 • 206 citations

Cytosolic Phospholipase A2 Is Required for Cytokine-induced Expression of Type IIA Secretory Phospholipase A2 That Mediates Optimal Cyclooxygenase-2-dependent Delayed Prostaglandin E2 Generation in Rat 3Y1 Fibroblasts

1998 • 190 citations

Molecular cloning of pancreatic group I phospholipase A2 receptor.

1994 • 183 citations

Segregated Coupling of Phospholipases A2, Cyclooxygenases, and Terminal Prostanoid Synthases in Different Phases of Prostanoid Biosynthesis in Rat Peritoneal Macrophages

1998 • 179 citations

Functional coupling between secretory phospholipase A₂and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A₂

1998 • 178 citations

Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2

1999 • 176 citations

Level of Expression of Phospholipid Scramblase Regulates Induced Movement of Phosphatidylserine to the Cell Surface

1998 • 171 citations

Functional Association of Type IIA Secretory Phospholipase A2 with the Glycosylphosphatidylinositol-anchored Heparan Sulfate Proteoglycan in the Cyclooxygenase-2-mediated Delayed Prostanoid-biosynthetic Pathway

1999 • 168 citations

Analysis of the Secretory Phospholipase A2 That Mediates Prostaglandin Production in Mast Cells

1997 • 164 citations

Secretory Phospholipase A2 Activates the Cascade of Mitogen-activated Protein Kinases and Cytosolic Phospholipase A2 in the Human Astrocytoma Cell Line 1321N1

1998 • 158 citations

Cloning and Characterization of Novel Mouse and Human Secretory Phospholipase A2s

1999 • 141 citations

Protection against Oxidative Stress-induced Cell Death by Intracellular Platelet-activating Factor-Acetylhydrolase II

1997 • 136 citations

Type II Secretory Phospholipase A2 Associated with Cell Surfaces via C-terminal Heparin-binding Lysine Residues Augments Stimulus-initiated Delayed Prostaglandin Generation

1996 • 133 citations

Transcellular Prostaglandin Production following Mast Cell Activation Is Mediated by Proximal Secretory Phospholipase A2 and Distal Prostaglandin Synthase 1

1996 • 113 citations

The perturbed membrane of cells undergoing apoptosis is susceptible to type II secretory phospholipase A2 to liberate arachidonic acid

1997 • 104 citations

Eicosanoid generation from antigen‐primed mast cells by extracellular mammalian 14‐kDa group II phospholipase A₂

1991 • 95 citations

Regulation of type V phospholipase A₂ expression and function by proinflammatory stimuli

1999 • 89 citations

Action of Human Group IIa Secreted Phospholipase A2on Cell Membranes

1998 • 88 citations

Induction of Cyclooxygenase-2 by Secretory Phospholipases A2 in Nerve Growth Factor-Stimulated Rat Serosal Mast Cells Is Facilitated by Interaction with Fibroblasts and Mediated by a Mechanism Independent of Their Enzymatic Functions

1998 • 88 citations

Tryptophan-Containing Mutant of Human (Group IIa) Secreted Phospholipase A₂ Has a Dramatically Increased Ability To Hydrolyze Phosphatidylcholine Vesicles and Cell Membranes

1998 • 82 citations

Expression and characterization of human group V phospholipase A2

1998 • 81 citations

Inflammatory Activation of Arachidonic Acid Signaling in Murine P388D1 Macrophages via Sphingomyelin Synthesis

1997 • 70 citations

Participation in cellular prostaglandin synthesis of type‐II phospholipase A₂ secreted and anchored on cell‐surface heparan sulfate proteoglycan

1993 • 70 citations

Augmentation of Prostaglandin E2 Production by Mammalian Phospholipase A2 Added Exogenously1

1991 • 58 citations

Immunochemical detection of ‘ platelet type’ phospholipase A2 in the rat

1990 • 53 citations

Monoclonal Antibodies against Rat Platelet Phospholipase A21

1988 • 41 citations

Lipid Peroxide Overcomes the Inability of Platelet Secretory Phospholipase A2 to Hydrolyze Membrane Phospholipids in Rabbit Platelets

1997 • 28 citations

Detection of secretory phospholipase A₂s related but not identical to type IIA isozyme in cultured mast cells

1997 • 19 citations

Human group II 14 kDa phospholipase A2 activates human platelets

1997 • 15 citations