Cloning and Characterization of Novel Mouse and Human Secretory Phospholipase A2s

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Genomic sequencing.

1984 • 8,343 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

Diversity of group types, regulation, and function of phospholipase A2.

1994 • 1,444 citations

The growing phospholipase A2 superfamily of signal transduction enzymes

1997 • 811 citations

Structure and Properties of a Human Non-pancreatic Phospholipase A2

1989 • 668 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Cloning and Recombinant Expression of Phospholipase A2 Present in Rheumatoid Arthritic Synovial Fluid

1989 • 542 citations

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

1995 • 529 citations

Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants.

1977 • 406 citations

Induction of phospholipase A2 gene expression in human hepatoma cells by mediators of the acute phase response

1991 • 406 citations

Role of secretory phospholipases A2 in the pathobiology of disease.

1986 • 382 citations

The Functions of Five Distinct Mammalian Phospholipase A2s in Regulating Arachidonic Acid Release

1998 • 369 citations

Antigen‐induced arthritis in mice

1977 • 334 citations

A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains

1995 • 327 citations

The apolipoprotein multigene family: biosynthesis, structure, structure-function relationships, and evolution.

1988 • 315 citations

A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs

1997 • 302 citations

A Reassessment of the Low Molecular Weight Phospholipase A2 Gene Family in Mammals

1997 • 284 citations

Novel Group V Phospholipase A2 Involved in Arachidonic Acid Mobilization in Murine P388D1 Macrophages

1996 • 259 citations

Cloning, Chromosomal Mapping, and Expression of a Novel Human Secretory Phospholipase A2

1997 • 256 citations

Sepsis-induced apoptosis of the thymocytes in mice.

1994 • 237 citations

A Novel Calcium-independent Phospholipase A2, cPLA2-γ, That Is Prenylated and Contains Homology to cPLA2

1998 • 230 citations

Pancreatic Phospholipase A₂: Isolation of the Human Gene and cDNAs from Porcine Pancreas and Human Lung

1986 • 225 citations

Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2.

1994 • 224 citations

Molecular nature of phospholipases A2 involved in prostaglandin I2 synthesis in human umbilical vein endothelial cells. Possible participation of cytosolic and extracellular type II phospholipases A2.

1993 • 210 citations

Potent Inhibitors of Secretory Phospholipase A2: Synthesis and Inhibitory Activities of Indolizine and Indene Derivatives

1996 • 210 citations

Purification and properties of an anionic zymogen of phospholipase a from porcine pancreas

1968 • 189 citations

Molecular cloning of pancreatic group I phospholipase A2 receptor.

1994 • 183 citations

Group II phospholipase A₂ mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells

1990 • 182 citations

Novel proliferative effect of phospholipase A2 in Swiss 3T3 cells via specific binding site.

1991 • 174 citations

Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.

1996 • 172 citations

Thromboxane A2: Its generation and role in platelet activation

1989 • 166 citations

Analysis of the Secretory Phospholipase A2 That Mediates Prostaglandin Production in Mast Cells

1997 • 164 citations

Circulating phospholipase A2 activity associated with sepsis and septic shock is indistinguishable from that associated with rheumatoid arthritis

1991 • 156 citations

Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule.

1985 • 141 citations

Resistance to Endotoxic Shock in Phospholipase A2 Receptor-deficient Mice

1997 • 134 citations

Type II Secretory Phospholipase A2 Associated with Cell Surfaces via C-terminal Heparin-binding Lysine Residues Augments Stimulus-initiated Delayed Prostaglandin Generation

1996 • 133 citations

Structural determinants of the action against Escherichia coli of a human inflammatory fluid phospholipase A2 in concert with polymorphonuclear leukocytes

1994 • 129 citations

Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1.

1988 • 128 citations

Cloning and characterization of novel rat and mouse low molecular weight Ca(2+)-dependent phospholipase A2s containing 16 cysteines.

1994 • 115 citations

cDNA Cloning and Expression of Intracellular Platelet-activating Factor (PAF) Acetylhydrolase II

1996 • 111 citations

Characterization of a high affinity binding site for pancreatic-type phospholipase A2 in the rat. Its cellular and tissue distribution.

1992 • 101 citations

Low-Molecular-Weight, Calcium-Dependent Phospholipase A2Genes Are Linked and Map to Homologous Chromosome Regions in Mouse and Human

1996 • 97 citations

A Heparin-sensitive Phospholipase A2 and Prostaglandin Endoperoxide Synthase-2 Are Functionally Linked in the Delayed Phase of Prostaglandin D2 Generation in Mouse Bone Marrow-derived Mast Cells

1996 • 96 citations

Use of long sequence alignments to study the evolution and regulation of mammalian globin gene clusters.

1993 • 90 citations

Serum phospholipase A2 correlates with disease activity in rheumatoid arthritis.

1988 • 87 citations

Pancreatic-type phospholipase A2 induces group II phospholipase A2 expression and prostaglandin biosynthesis in rat mesangial cells.

1994 • 83 citations

Structural Comparison of phospholipase‐A₂‐binding Regions in phospholipase‐A₂ Receptors from Various Mammals

1994 • 82 citations

Structure and function of phospholipase A2 receptor

1995 • 72 citations

Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site.

1993 • 67 citations

Increased Concentrations of Synovial-Type Phospholipase A<sub>2</sub> in Serum and Pulmonary and Renal Complications in Acute Pancreatitis

1992 • 66 citations

Reverse-phase high-performance liquid chromatographic assay of phospholipases: application of spectrophotometric detection to rat phospholipase A2 isozymes

1993 • 60 citations

Conversion of pig pancreas phospholipase A2 by protein engineering into enzyme active against Escherichia coli treated with the bactericidal/permeability-increasing protein

1991 • 50 citations

The purification and characterization of a phospholipase A₂ activity from the 106 000 × g pellet (microsomal fraction) of bovine brain acting on phosphatidylinositol

1982 • 38 citations

A simple and sensitive method for determining transcription initiation site: identification of two transcription initiation sites in rat group II phospholipase A₂gene

1990 • 29 citations

Dependence of thymocyte apoptosis on protein kinase C and phospholipase A₂

1994 • 28 citations

The phospholipase A2 of human spermatozoa; purification and partial sequence

1992 • 25 citations

Intercellular interactions in the interphase death of irradiated thymocytes.

1993 • 19 citations

Intercellular Interactions in the Interphase Death of Irradiated Thymocytes

1993 • 13 citations

Increased activity of group II phospholipase A₂ in plasma in rat sodium deoxycholate induced acute pancreatitis

1997 • 13 citations

TaqI dimorphic site in a human pancreatic phospholipase A2 (PLA2) gene localized on chromosome 12

1994 • 2 citations