Drug Membrane Interaction and the Importance for Drug Transport, Distribution, Accumulation, Efficacy and Resistance

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Reversal of Chloroquine Resistance in Plasmodium falciparum by Verapamil

1987 • 558 citations

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

1988 • 514 citations

Reevaluating equilibrium and kinetic binding parameters for lipophilic drugs based on a structural model for drug interactions with biological membranes

1991 • 194 citations

QSAR: Rational approaches to the design of bioactive compounds

1991 • 185 citations

QSAR and strategies in the design of bioactive compounds

1985 • 156 citations

Estimated conformation, orientation, and accumulation of dynorphin A-(1-13)-tridecapeptide on the surface of neutral lipid membranes

1986 • 105 citations

Trends in medicinal chemistry

1988 • 99 citations

The liposome as a model membrane in correlations of partitioning with alpha-adrenoceptor agonist activities.

1990 • 55 citations

Possible molecular basis for the pharmacokinetics and pharmacodynamics of three membrane-active drugs: Propranolol, nimodipine and amiodarone+

1988 • 53 citations

Membrane effects of antiinflammatory agents. 2. Interaction of nonsteroidal antiinflammatory drugs with liposome and purple membranes

1981 • 47 citations

The Importance of Drug‐Membrane Interaction in Drug Research and Development

1992 • 43 citations

New approaches to drug design and delivery based on drug-membrane interactions.

1991 • 35 citations

Nuclear magnetic resonance and differential scanning calorimetry as tools for studying drug-membrane interactions

1991 • 22 citations

A semiautomated 96-well plate assay for protein kinase C

1990 • 15 citations

Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate

1985 • 14 citations

QSAR and Multivariate Data Analysis of Amphiphilic Benzylamines and their Interaction with Various Phospholipids Determined by Different Methods

1989 • 14 citations

Phosphatidylserine monolayers as models for drug uptake into membranes and tissue

1990 • 8 citations

QSAR and Molecular Modelling for a Series of Isomeric X‐Sulfanilamido‐1‐phenylpyrazoles

1993 • 5 citations

Computer Modeling and NMR Studies of Interactions Between Phospholipids and Benzylamines

1992 • 4 citations