A labile transcriptional repressor modulates endotoxin tolerance.

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Activation in vitro of NF-κB" by phosphorylation of its inhibitor IκB"

1990 • 1,202 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Dysregulation of in vitro cytokine production by monocytes during sepsis.

1991 • 747 citations

Characterization of a functional NF-kappa B site in the human interleukin 1 beta promoter: evidence for a positive autoregulatory loop.

1993 • 600 citations

Gamma interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin 1, and urokinase genes, which are controlled by short-lived repressors.

1986 • 532 citations

Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.

1993 • 530 citations

Amplification and Adaptation in Regulatory and Sensory Systems

1982 • 464 citations

Purified human IκB can rapidly dissociate the complex of the NF-κB transcription factor with its cognate DNA

1990 • 445 citations

G protein—coupled receptor kinases

1993 • 434 citations

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

1992 • 324 citations

Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy

1992 • 322 citations

Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells

1993 • 239 citations

Adaptation to bacterial lipopolysaccharide controls lipopolysaccharide-induced tumor necrosis factor production in rabbit macrophages.

1990 • 214 citations

Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction.

1986 • 204 citations

Intravenous endotoxin suppresses the cytokine response of peripheral blood mononuclear cells of healthy humans.

1993 • 195 citations

Tolerance to endotoxin-induced expression of the interleukin-1 beta gene in blood neutrophils of humans with the sepsis syndrome.

1993 • 192 citations

Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex.

1992 • 181 citations

The human prointerleukin 1 beta gene requires DNA sequences both proximal and distal to the transcription start site for tissue-specific induction.

1993 • 180 citations

Lipopolysaccharide-induced selective priming effects on tumor necrosis factor alpha and nitric oxide production in mouse peritoneal macrophages.

1993 • 175 citations

Lipopolysaccharide Induces Hyporesponsiveness to Its Own Action in RAW 264.7 Cells

1989 • 162 citations

Characterization of a Functional NF-κB Site in the Human Interleukin 1β Promoter: Evidence for a Positive Autoregulatory Loop

1993 • 156 citations

Molecular mechanisms in down-regulation of tumor necrosis factor expression.

1990 • 120 citations

Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression.

1989 • 116 citations

Functional and Physical Associations between NF-κB and C/EBP Family Members: a Rel Domain-bZIP Interaction

1993 • 112 citations

Endotoxin tolerance: independent regulation of interleukin-1 and tumor necrosis factor expression

1991 • 107 citations

Review: Transcriptional and post-transcriptional regulation of interleukin 1 gene expression

1992 • 103 citations

In vitro desensitization to lipopolysaccharide suppresses tumour necrosis factor, interleukin-1 and interleukin-6 gene expression in a similar fashion.

1992 • 92 citations

A CRE/ATF-Like Site in the Upstream Regulatory Sequence of the Human Interleukin 1β Gene Is Necessary for Induction in U937 and THP-1 Monocytic Cell Lines

1993 • 85 citations

Labile proteins play a dual role in the control of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene regulation.

1992 • 52 citations

The Human Prointerleukin 1β Gene Requires DNA Sequences Both Proximal and Distal to the Transcription Start Site for Tissue-Specific Induction

1993 • 37 citations

Molecular regulation of human interleukin 2 and T-cell function by interleukin 4.

1993 • 35 citations

Purifying nascent mRNA from nuclear run-on assays using guanidinium isothiocyanate.

1993 • 26 citations