Comparable changes in synaptic dopamine induced by methylphenidate and by cocaine in the baboon brain

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

1987 • 2,189 citations

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method

1997 • 1,147 citations

Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects

1997 • 843 citations

Relationship between subjective effects of cocaine and dopamine transporter occupancy

1997 • 653 citations

Is Methylphenidate Like Cocaine?

1995 • 575 citations

Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys.

1989 • 389 citations

Imaging endogenous dopamine competition with [¹¹C]raclopride in the human brain

1994 • 378 citations

Endogenous dopamine lowers the dopamine D₂ receptor density as measured by [³H]raclopride: Implications for positron emission tomography of the human brain

1989 • 298 citations

Amphetamine, cocaine, and fencamfamine: relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics

1991 • 289 citations

Striatal binding of the PET ligand ¹¹C‐raclopride is altered by drugs that modify synaptic dopamine levels

1993 • 285 citations

Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans

1997 • 266 citations

Effects of cocaine and related drugs in nonhuman primates. I. [3H]cocaine binding sites in caudate-putamen.

1989 • 236 citations

A choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey.

1975 • 235 citations

Cocaine: An in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum

1989 • 218 citations

Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters

1996 • 199 citations

Individual differences in basal and cocaine-stimulated extracellular dopamine in the nucleus accumbens using quantitative microdialysis

1992 • 196 citations

Pharmacology of the enantiomers of threo-methylphenidate.

1987 • 192 citations

Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain.

1993 • 183 citations

Effects of Blood Flow on [¹¹C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET Data

1994 • 171 citations

Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: Comparison to amphetamine

1989 • 156 citations

Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects.

1996 • 155 citations

Chiral drugs: comparison of the pharmacokinetics of [ 11 C] d-threo and l-threo -methylphenidate in the human and baboon brain

1997 • 153 citations

PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects

1997 • 151 citations

Relationship between psychostimulant-induced "high" and dopamine transporter occupancy.

1996 • 148 citations

In Vivo Microdialysis as a Technique to Monitor Drug Transport: Correlation of Extracellular Cocaine Levels and Dopamine Overflow in the Rat Brain

1988 • 141 citations

Intravenous methylphenidate abuse. Prototype for prescription drug abuse.

1991 • 137 citations

Comparison of the effects of cocaine and other inhibitors of dopamine uptake in rat striatum, nucleus accumbens, olfactory tubercle, and medial prefrontal cortex

1990 • 128 citations

Mapping muscarinic receptors in human and baboon brain using [N‐¹¹C‐methyl]‐benztropine

1990 • 113 citations

Intravenous Methylphenidate Abuse

1991 • 94 citations

Characterisation of methylphenidate and nomifensine induced dopamine release in rat striatum using in vivo brain microdialysis

1991 • 87 citations

Rate of binding of various inhibitors at the dopamine transporter in vivo

1995 • 76 citations

Pharmacokinetics and in vivo specificity of [^LLC]dl‐threo‐methylphenidate for the presynaptic dopaminergic neuron

1994 • 75 citations

Behavioral and Cardiovascular Effects of Intravenous Methylphenidate in Normal Subjects and Cocaine Abusers

1997 • 70 citations

Measuring dopamine transporter occupancy by cocaine in vivo: Radiotracer considerations

1998 • 67 citations

Carbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study.

1995 • 49 citations

Use of Positron Emission Tomography to Study the Dynamics of Psychostimulant-Induced Dopamine Release

1997 • 48 citations

Pharmacokinetics and pharmacodynamics of methylphenidate enantiomers in rats

1996 • 37 citations

Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters

1996 • 36 citations

Dopamine release during cocaine self-administration in rats: effect of SCH23390

1995 • 25 citations

Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey.

1992 • 23 citations

Biochemical Characterization of Dopamine Receptors

1997 • 22 citations

Differential Effects of Chloral Hydrate and Pentobarbital Sodium on a Cocaine Level and Its Catecholamine Response in the Medial Prefrontal Cortex: A Comparison with Conscious Rats

1995 • 20 citations

Endogenously released dopamine inhibits the binding of dopaminergic PET and SPECT ligands in superfused rat striatal slices

1996 • 20 citations