Measuring dopamine transporter occupancy by cocaine in vivo: Radiotracer considerations

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-¹¹C-Methyl]-(−)-Cocaine PET Studies in Human Subjects

1990 • 1,412 citations

Relationship between subjective effects of cocaine and dopamine transporter occupancy

1997 • 653 citations

SPECT imaging of dopamine and serotonin transporters with [¹²³I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates

1993 • 357 citations

Compartmental Analysis of [¹¹C]Flumazenil Kinetics for the Estimation of Ligand Transport Rate and Receptor Distribution Using Positron Emission Tomography

1991 • 344 citations

Mapping cocaine binding sites in human and baboon brain in vivo

1989 • 300 citations

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography

1992 • 211 citations

Pet study of [¹¹C] β‐CIT binding to monoamine transporters in the monkey and human brain

1994 • 184 citations

In vivo imaging of baboon and human dopamine transporters by positron emission tomography using [¹¹C]WIN 35,428

1993 • 178 citations

Effects of Blood Flow on [¹¹C]Raclopride Binding in the Brain: Model Simulations and Kinetic Analysis of PET Data

1994 • 171 citations

Relationship between psychostimulant-induced "high" and dopamine transporter occupancy.

1996 • 148 citations

High affinity dopamine reuptake inhibitors as potential cocaine antagonists: A strategy for drug development

1990 • 126 citations

A new PET ligand for the dopamine transporter: studies in the human brain.

1995 • 121 citations

Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter

1992 • 81 citations

Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency.

1992 • 80 citations

Euphorigenic doses of cocaine reduce [123I]β-CIT SPECT measures of dopamine transporter availability in human cocaine addicts

1995 • 61 citations

Carbon-11-d-threo-methylphenidate binding to dopamine transporter in baboon brain.

1995 • 61 citations

Plasma input function determination for PET using a commercial laboratory robot

1995 • 53 citations

Carbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study.

1995 • 49 citations

Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909

1991 • 45 citations

Cocaine doses equivalent to those abused by humans occupy most of the dopamine transporters

1996 • 36 citations

Synthesis of the racemate and individual enantiomers of [11C]methylphenidate for studying presynaptic dopaminergic neuron with positron emission tomography

1994 • 33 citations

Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine

1997 • 33 citations

Displacement of RTI-55 from the dopamine transporter by cocaine

1996 • 12 citations

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