Type I interferons produced by dendritic cells promote their phenotypic and functional activation

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors

1999 • 1,679 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Consequences of Cell Death

2000 • 1,382 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal

1999 • 957 citations

Type I Interferons Potently Enhance Humoral Immunity and Can Promote Isotype Switching by Stimulating Dendritic Cells In Vivo

2001 • 942 citations

Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

2000 • 867 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

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Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.

1996 • 653 citations

Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice

2000 • 650 citations

The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.

1992 • 642 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

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Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

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Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

Differential Production of IL-12, IFN-α, and IFN-γ by Mouse Dendritic Cell Subsets

2001 • 496 citations

Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

2000 • 477 citations

Role of interferons and other cytokines in the regulation of the immune response

1995 • 462 citations

IFN-γ production by antigen-presenting cells: mechanisms emerge

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Oligosaccharides of Hyaluronan Are Potent Activators of Dendritic Cells

2000 • 386 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 375 citations

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

1995 • 353 citations

The role of dendritic cells in the induction and regulation of immunity to microbial infection

1999 • 308 citations

Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming

2000 • 285 citations

The function of type I interferons in antimicrobial immunity

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Interferon-α and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent antigen-presenting cells

1998 • 271 citations

The Type I Interferon Receptor: Structure, Function, and Evolution of a Family Business

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Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection.

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A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

The control of T cell responses by dendritic cell subsets

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Coordinated events during bacteria-induced DC maturation

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Self-MHC-restricted peptides recognized by an alloreactive T lymphocyte clone.

1996 • 205 citations

IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.

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Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression

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A Method for the Large Scale Production of Potent Interferon Preparations

1974 • 184 citations

Identification of genes specifically expressed in human activated and mature dendritic cells through serial analysis of gene expression

2000 • 135 citations

Injection of mice with antibody to interferon renders peritoneal macrophages permissive for vesicular stomatitis virus and encephalomyocarditis virus.

1984 • 124 citations

Low Levels of Interferon‐α Induce CD86 (B7.2) Expression and Accelerates Dendritic Cell Maturation from Human Peripheral Blood Mononuclear Cells

1999 • 115 citations

Virus interactions with dendritic cells.

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Interferons, a group of multiple lymphokines

1984 • 103 citations

Interferon-α and -β inhibit the in vitro differentiation of immunocompetent human dendritic cells from CD14+ precursors

2000 • 100 citations

The heat shock protein gp96 induces maturation of dendritic cells and down-regulation of its receptor

2000 • 80 citations

The effects of DNA containing CpG motif on dendritic cells

2000 • 67 citations

Injection of mice with antibody to mouse interferon alpha/beta decreases the level of 2'-5' oligoadenylate synthetase in peritoneal macrophages

1985 • 63 citations

Studies on the Expression of Spontaneous and Induced Interferons in Mouse Peritoneal Macrophages by Means of Monoclonal Antibodies to Mouse Interferons

1987 • 60 citations

Clonal heterogeneity of dendritic cells derived from patients with chronic myeloid leukemia and enhancement of their T-cells stimulatory activity by IFN-α

1999 • 52 citations

Production of Interferon‐α/β by Murine Dendritic Cell Lines Stimulated by Virus and Bacteria

1997 • 44 citations

Correlation between the lipopolysaccharide response of mice and the capacity of mouse peritoneal cells to transfer an antiviral state. Role of endogenous interferon.

1987 • 25 citations

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