The effects of DNA containing CpG motif on dendritic cells

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

1996 • 1,498 citations

Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene Immunization

1996 • 1,078 citations

CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity

1997 • 1,008 citations

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

1998 • 809 citations

Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo.

1996 • 800 citations

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.

1996 • 764 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

1997 • 526 citations

Contribution of CpG motifs to the immunogenicity of DNA vaccines.

1997 • 519 citations

Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides.

1996 • 438 citations

Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor‐α‐mediated shock

1997 • 422 citations

Type I Interferon-mediated Stimulation of T Cells by CpG DNA

1998 • 361 citations

CpG Motifs in Bacterial DNA Activate Leukocytes Through the pH-Dependent Generation of Reactive Oxygen Species

1998 • 331 citations

Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway.

1996 • 288 citations

Immunostimulatory DNA: Sequence‐dependent production of potentially harmful or useful cytokines

1997 • 248 citations

Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein

1997 • 241 citations

Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesisin vitro

1999 • 231 citations

CpG-Containing Oligonucleotides Are Efficient Adjuvants for Induction of Protective Antiviral Immune Responses with T-Cell Peptide Vaccines

1999 • 132 citations

Oligonucleotide Adjuvants for T Helper 1 (Th1)–specific Vaccination

1997 • 109 citations

Dendritic cells

1998 • 107 citations