Disruption of Lens Fiber Cell Differentiation and Survival at Multiple Stages by Region-Specific Expression of Truncated FGF Receptors

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.

1991 • 1,358 citations

Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos

1991 • 1,103 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

1996 • 867 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Lens Differentiation in Vertebrates

1981 • 638 citations

Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development

1998 • 618 citations

Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2

1998 • 593 citations

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1998 • 555 citations

Fibroblast Growth Factors as Multifunctional Signaling Factors

1998 • 489 citations

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice

1998 • 437 citations

Targeted expression of a dominant negative FGF receptor blocks branching morphogenesis and epithelial differentiation of the mouse lung.

1994 • 432 citations

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.

1994 • 406 citations

Fibroblast growth factor 2 control of vascular tone

1998 • 376 citations

Involvement of heparan sulfate and related molecules in sequestration and growth promoting activity of fibroblast growth factor

1996 • 287 citations

A truncated form of fibroblast growth factor receptor 1 inhibits signal transduction by multiple types of fibroblast growth factor receptor.

1992 • 272 citations

Lens Development: Fiber Elongation and Lens Orientation

1963 • 243 citations

Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice.

1985 • 242 citations

Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation.

1993 • 240 citations

Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice

1995 • 222 citations

Lens metabolic cooperation: a study of mouse lens transport and permeability visualized with freeze-substitution autoradiography and electron microscopy.

1980 • 194 citations

Overlapping effects of different members of the FGF family on lens fiber differentiation in transgenic mice

1998 • 178 citations

Expression of a truncated FGF receptor results in defective lens development in transgenic mice

1995 • 176 citations

FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens

1995 • 154 citations

In Situ Detection of β-Galactosidase in Lenses of Transgenic Mice with a γ-Crystallin/ lacZ Gene

1987 • 137 citations

The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity

1998 • 130 citations

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

1993 • 123 citations

The Role of Fibroblast Growth Factor in Eye Lens Development^a

1991 • 118 citations

Disregulation of Ocular Morphogenesis by Lens-Specific Expression of FGF-3/Int-2 in Transgenic Mice

1998 • 106 citations

Identification of Glypican as a Dual Modulator of the Biological Activity of Fibroblast Growth Factors

1997 • 105 citations

Divalent Cations and Heparin/Heparan Sulfate Cooperate to Control Assembly and Activity of the Fibroblast Growth Factor Receptor Complex

1996 • 103 citations

Dye Transfer Between Cells of the Lens

1996 • 93 citations

Intercellular communication between epithelial and fiber cells of the eye lens

1994 • 92 citations

Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor.

1996 • 90 citations

Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth.

1997 • 89 citations

Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens: implications for lens polarity and growth patterns.

1993 • 87 citations

Evidence for two physiologically distinct gap junctions expressed by the chick lens epithelial cell.

1986 • 76 citations

Fibroblast growth factor receptor signalling has a role in lobuloalveolar development of the mammary gland

1997 • 75 citations

Distribution of Acidic and Basic Fibroblast Growth Factors (FGF) in the Foetal Rat Eye: Implications for Lens Development

1992 • 74 citations

The electrical coupling of epithelium and fibers in the frog lens

1983 • 74 citations

Fibre differentiation and polarity in the mammalian lens: a key role for FGF

1997 • 72 citations

Retinal degeneration in transgenic mice with photoreceptor-specific expression of a dominant-negative fibroblast growth factor receptor

1996 • 72 citations

Induction and Maintenance of Differentiation of Rat Lens Epithelium by FGF-2, Insulin and IGF-1

1998 • 72 citations

Overexpression of FGF-2 modulates fiber cell differentiation and survival in the mouse lens

1997 • 68 citations

Lens-specific promoter activity of a mouse gamma-crystallin gene.

1985 • 67 citations

Heparan sulfate fibroblast growth factor receptor complex: Structure-function relationships

1994 • 66 citations

Expression of FGF-1 and FGF-2 mRNA during lens morphogenesis, differentiation and growth

1997 • 65 citations

Cataracts and abnormal proliferation of the lens epithelium in mice carrying the CatFr gene

1969 • 62 citations

FGF receptor-1 (flg) expression is correlated with fibre differentiation during rat lens morphogenesis and growth

1996 • 54 citations

Differentiation and oncogenesis: phenotypically distinct lens tumors in transgenic mice.

1989 • 48 citations

Binding of FGF-1 and FGF-2 to Heparan Sulphate Proteoglycans of the Mammalian Lens Capsule

1997 • 46 citations

Homologous and heterologous enhancers modulate spatial expression but not cell-type specificity of the murine γF-crystallin promoter

1990 • 42 citations