Transposable elements and the epigenetic regulation of the genome

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

2000 • 8,948 citations

The Significance of Responses of the Genome to Challenge

1984 • 2,520 citations

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

1997 • 2,256 citations

Transposable Elements: Targets for Early Nutritional Effects on Epigenetic Gene Regulation

2003 • 1,970 citations

Mobile Elements: Drivers of Genome Evolution

2004 • 1,833 citations

Selfish genes, the phenotype paradigm and genome evolution

1980 • 1,779 citations

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

2001 • 1,672 citations

A germline-specific class of small RNAs binds mammalian Piwi proteins

2006 • 1,629 citations

Genetic and Functional Diversification of Small RNA Pathways in Plants

2004 • 1,553 citations

A novel class of small RNAs bind to MILI protein in mouse testes

2006 • 1,439 citations

Epigenetic inheritance at the agouti locus in the mouse

1999 • 1,414 citations

Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells

1997 • 1,383 citations

Dnmt3L and the Establishment of Maternal Genomic Imprints

2001 • 1,356 citations

The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans

1999 • 1,286 citations

A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline

2006 • 1,277 citations

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

2005 • 1,253 citations

Role of transposable elements in heterochromatin and epigenetic control

2004 • 1,198 citations

Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L

2004 • 1,130 citations

The DNA sequence of the human X chromosome

2005 • 1,118 citations

Two classes of short interfering RNA in RNA silencing

2002 • 1,022 citations

Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.

1998 • 964 citations

A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal

1998 • 955 citations

The Small RNA Profile during Drosophila melanogaster Development

2003 • 955 citations

RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse

2006 • 897 citations

Maternal epigenetics and methyl supplements affectagoutigene expression inA^vy/amice

1998 • 851 citations

RNAi-mediated pathways in the nucleus

2005 • 839 citations

A novel class of small RNAs in mouse spermatogenic cells

2006 • 827 citations

Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring

2002 • 782 citations

Role of the Arabidopsis DRM Methyltransferases in De Novo DNA Methylation and Gene Silencing

2002 • 732 citations

RNA Polymerase IV Directs Silencing of Endogenous DNA

2005 • 702 citations

Retrotransposons Regulate Host Genes in Mouse Oocytes and Preimplantation Embryos

2004 • 664 citations

Plant Nuclear RNA Polymerase IV Mediates siRNA and DNA Methylation-Dependent Heterochromatin Formation

2005 • 635 citations

Insulators: exploiting transcriptional and epigenetic mechanisms

2006 • 630 citations

The profile of repeat-associated histone lysine methylation states in the mouse epigenome

2005 • 626 citations

A Two-Hit Trigger for siRNA Biogenesis in Plants

2006 • 622 citations

Transposable elements and the evolution of genome size in eukaryotes.

2002 • 600 citations

DNA methyltransferases control telomere length and telomere recombination in mammalian cells

2006 • 580 citations

Origin of a substantial fraction of human regulatory sequences from transposable elements

2003 • 575 citations

The role of RNA interference in heterochromatic silencing

2004 • 563 citations

Doubling genome size without polyploidization: Dynamics of retrotransposition-driven genomic expansions in Oryza australiensis, a wild relative of rice

2006 • 553 citations

Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes

2006 • 553 citations

One-Way Control of FWA Imprinting in Arabidopsis Endosperm by DNA Methylation

2003 • 542 citations

Two RNAi Complexes, RITS and RDRC, Physically Interact and Localize to Noncoding Centromeric RNAs

2004 • 540 citations

DNA Methylation and Epigenetic Inheritance in Plants and Filamentous Fungi

2001 • 501 citations

Metastable epialleles in mammals

2002 • 496 citations

SELFISH DNA: A SEXUALLY-TRANSMITTED NUCLEAR PARASITE

1982 • 490 citations

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

2004 • 484 citations

Mobile elements and mammalian genome evolution

2003 • 475 citations

Stress and transposable elements: co-evolution or useful parasites?

2000 • 469 citations

RAG1 Core and V(D)J Recombination Signal Sequences Were Derived from Transib Transposons

2005 • 467 citations

Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi

2003 • 444 citations

Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation

2006 • 436 citations

Dependence of Heterochromatic Histone H3 Methylation Patterns on the Arabidopsis Gene DDM1

2002 • 434 citations

The Arabidopsis Chromatin-Modifying Nuclear siRNA Pathway Involves a Nucleolar RNA Processing Center

2006 • 428 citations

Distinct Mechanisms Determine Transposon Inheritance and Methylation via Small Interfering RNA and Histone Modification

2003 • 403 citations

Atypical RNA polymerase subunits required for RNA-directed DNA methylation

2005 • 397 citations

Differential lineage-specific amplification of transposable elements is responsible for genome size variation in Gossypium

2006 • 397 citations

L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells

2006 • 386 citations

An ARGONAUTE4-Containing Nuclear Processing Center Colocalized with Cajal Bodies in Arabidopsis thaliana

2006 • 379 citations

Tethering RITS to a Nascent Transcript Initiates RNAi- and Heterochromatin-Dependent Gene Silencing

2006 • 376 citations

Reinforcement of silencing at transposons and highly repeated sequences requires the concerted action of two distinct RNA polymerases IV in Arabidopsis

2005 • 373 citations

An RNA-dependent RNA polymerase is required for paramutation in maize

2006 • 366 citations

Transposable elements and host genome evolution

2000 • 341 citations

Retrotransposons as epigenetic mediators of phenotypic variation in mammals

2001 • 339 citations

Position effect variegation at fission yeast centromeres

1994 • 332 citations

RNAi-Independent Heterochromatin Nucleation by the Stress-Activated ATF/CREB Family Proteins

2004 • 321 citations

RNAi-Mediated Allelic trans-Interaction at the Imprinted Rtl1/Peg11 Locus

2005 • 313 citations

A molecular view of plant centromeres

2003 • 305 citations

Drosophila rasiRNA Pathway Mutations Disrupt Embryonic Axis Specification through Activation of an ATR/Chk2 DNA Damage Response

2007 • 291 citations

CENP-B box is required for de novo centromere chromatin assembly on human alphoid DNA

2002 • 291 citations

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

2005 • 275 citations

Differential chromatin structure within a tandem array 100 kb upstream of the maize b1 locus is associated with paramutation

2002 • 272 citations

Co-evolution of X-chromosome inactivation and imprinting in mammals

2005 • 263 citations

Endogenous targets of RNA-directed DNA methylation and Pol IV in Arabidopsis

2006 • 262 citations

A Retrotransposon-Derived Gene, PEG10, Is a Novel Imprinted Gene Located on Human Chromosome 7q21

2001 • 257 citations

Dynamic Reprogramming of DNA Methylation at an Epigenetically Sensitive Allele in Mice

2006 • 244 citations

Evidence for a piwi-Dependent RNA Silencing of the gypsy Endogenous Retrovirus by the Drosophila melanogaster flamenco Gene

2004 • 236 citations

Many Human Genes Are Transcribed from the Antisense Promoter of L1 Retrotransposon

2002 • 223 citations

Remarkable variation in maize genome structure inferred from haplotype diversity at the bz locus

2006 • 222 citations

Taming of transposable elements by homology-dependent gene silencing

1999 • 221 citations

Antisense intergenic transcription in V(D)J recombination

2004 • 220 citations

Small RNAs in genome rearrangement in Tetrahymena

2004 • 210 citations

Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila

2003 • 207 citations

Maintenance of heterochromatin by RNA interference of tandem repeats

2003 • 203 citations

A Genome-Wide Screen Identifies 27 Genes Involved in Transposon Silencing in C. elegans

2003 • 198 citations

Argonaute Slicing Is Required for Heterochromatic Silencing and Spreading

2006 • 195 citations

Differential Regulation of Strand-Specific Transcripts from Arabidopsis Centromeric Satellite Repeats

2005 • 183 citations

Structural and Functional Dynamics of Human Centromeric Chromatin

2006 • 182 citations

Heritable transposon silencing initiated by a naturally occurring transposon inverted duplication

2005 • 177 citations

Two-Step Recruitment of RNA-Directed DNA Methylation to Tandem Repeats

2006 • 175 citations

Asymmetric Methylation in the Hypermethylated CpG Promoter Region of the Human L1 Retrotransposon

1997 • 169 citations

The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells

2003 • 167 citations

Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline

2006 • 164 citations

Short interspersed transposable elements (SINEs) are excluded from imprinted regions in the human genome

2001 • 156 citations

The role of heterochromatin in centromere function

2005 • 151 citations

Fitness cost of LINE-1 (L1) activity in humans

2006 • 140 citations

RNA interference and heterochromatin in the fission yeast Schizosaccharomyces pombe

2005 • 139 citations

RNA interference machinery influences the nuclear organization of a chromatin insulator

2006 • 138 citations

High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes

2003 • 138 citations

Lsh, an epigenetic guardian of repetitive elements

2004 • 138 citations

Genome-Wide Analysis of mRNAs Regulated by Drosha and Argonaute Proteins in Drosophila melanogaster

2006 • 137 citations

Global Effects on Gene Expression in Fission Yeast by Silencing and RNA Interference Machineries

2005 • 137 citations

L1 Antisense Promoter Drives Tissue‐Specific Transcriptionof Human Genes

2006 • 128 citations

Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells

2006 • 122 citations

Coordinate suppression of mutations caused by Robertson's mutator transposons in maize.

1994 • 117 citations

Dnmt1 Expression in Pre- and Postimplantation Embryogenesis and the Maintenance of IAP Silencing

2004 • 115 citations

Repeated Recruitment of LTR Retrotransposons as Promoters by the Anti-Apoptotic Locus NAIP during Mammalian Evolution

2007 • 114 citations

Active retrotransposition by a synthetic L1 element in mice

2006 • 112 citations

A Small Family of Sushi-Class Retrotransposon-Derived Genes in Mammals and Their Relation to Genomic Imprinting

2005 • 112 citations

Alu repeated DNAs are differentially methylated in primate germ cells

1994 • 107 citations

Extensive individual variation in L1 retrotransposition capability contributes to human genetic diversity

2006 • 104 citations

cis-Acting Determinants of Heterochromatin Formation on Drosophila melanogaster Chromosome Four

2004 • 103 citations

Centromeres put epigenetics in the driver's seat

2006 • 102 citations

Initiation, Establishment, and Maintenance of Heritable MuDR Transposon Silencing in Maize Are Mediated by Distinct Factors

2006 • 100 citations

Functional Genomics Reveals Relationships Between the Retrovirus-Like Ty1 Element and Its Host Saccharomyces cerevisiae

2003 • 98 citations

Paramutation of the r1 Locus of Maize Is Associated With Increased Cytosine Methylation

1998 • 97 citations

Evolutionary dynamics of transposable elements at the centromere

2004 • 95 citations

Genetics and epigenetics in flower pigmentation associated with transposable elements in morning glories

2004 • 93 citations

SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing.

2003 • 92 citations

Two retrotransposons maintain telomeres in Drosophila

2005 • 89 citations

Epigenetic regulation of the maize Spm transposable element: Novel activation of a methylated promoter by TnpA

1994 • 85 citations

The DXPas34 Repeat Regulates Random and Imprinted X Inactivation

2007 • 80 citations

Epigenetic Control of CACTA Transposon Mobility in Arabidopsis thaliana

2004 • 80 citations

Interindividual variability and parent of origin DNA methylation differences at specific human Alu elements

2005 • 77 citations

A SNF2‐like protein facilitates dynamic control of DNA methylation

2005 • 76 citations

Element 1360 and RNAi Components Contribute to HP1-Dependent Silencing of a Pericentric Reporter

2006 • 74 citations

Association of Lsh, a Regulator of DNA Methylation, with Pericentromeric Heterochromatin Is Dependent on Intact Heterochromatin

2003 • 72 citations

RNA silencing in Drosophila

2005 • 71 citations

Regulatory changes as a consequence of transposon insertion

1999 • 71 citations

Genome evolution mediated by Ty elements in <i>Saccharomyces</i>

2005 • 64 citations

Meiotically Stable Natural Epialleles of Sadhu, a Novel Arabidopsis Retroposon

2006 • 61 citations

Components of action of the regulators Spm and Ac

1965 • 61 citations

Drosophila melanogaster P Transposable Elements: Mechanisms of Transposition and Regulation

2004 • 60 citations

Repetitive elements in imprinted genes

2006 • 60 citations

What transposable elements tell us about genome organization and evolution: the case of <i>Drosophila</i>

2005 • 59 citations

aubergine mutations in Drosophila melanogaster impair P cytotype determination by telomeric P elements inserted in heterochromatin.

2004 • 58 citations

Do LINEs Have a Role in X‐Chromosome Inactivation?

2006 • 50 citations

Reciprocal differences in female recombination associated with hybrid dysgenesis inDrosophila Melanogaster

1977 • 46 citations

Genetic and epigenetic regulation of IgH gene assembly

2006 • 39 citations

Transcriptionally Silenced Transgenes in Maize Are Activated by Three Mutations Defective in Paramutation

2006 • 39 citations

Telomeric transgenes and trans-silencing in Drosophila.

2003 • 37 citations

A temperature cline in copy number for 412 but not roo/B104 retrotransposons in populations of Drosophila simulans

1998 • 32 citations

The Mutant Phenotype Associated With P-Element Alleles of the vestigial Locus in Drosophila melanogaster May Be Caused by a Readthrough Transcript Initiated at the P-Element Promoter

2001 • 21 citations

RNA interference has a role in regulating Drosophila telomeres.

2006 • 4 citations