Drosophila rasiRNA Pathway Mutations Disrupt Embryonic Axis Specification through Activation of an ATR/Chk2 DNA Damage Response

A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

1989 • 2,555 citations

A microRNA in a Multiple-Turnover RNAi Enzyme Complex

2002 • 2,052 citations

Dicer is essential for mouse development

2003 • 1,896 citations

Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing

2001 • 1,847 citations

A germline-specific class of small RNAs binds mammalian Piwi proteins

2006 • 1,629 citations

Chk1 and Chk2 kinases in checkpoint control and cancer

2003 • 1,458 citations

A novel class of small RNAs bind to MILI protein in mouse testes

2006 • 1,439 citations

MicroRNAs Regulate Brain Morphogenesis in Zebrafish

2005 • 1,287 citations

A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline

2006 • 1,277 citations

Distinct Roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA Silencing Pathways

2004 • 1,254 citations

miwi, a Murine Homolog of piwi, Encodes a Cytoplasmic Protein Essential for Spermatogenesis

2002 • 840 citations

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

2004 • 831 citations

A novel class of small RNAs in mouse spermatogenic cells

2006 • 827 citations

Histone H2A variants H2AX and H2AZ

2002 • 749 citations

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

2001 • 745 citations

RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila

2006 • 695 citations

Stem cell division is regulated by the microRNA pathway

2005 • 678 citations

A Protein Sensor for siRNA Asymmetry

2004 • 584 citations

Essential function in vivo for Dicer-2 in host defense against RNA viruses in drosophila

2006 • 539 citations

Normal microRNA Maturation and Germ-Line Stem Cell Maintenance Requires Loquacious, a Double-Stranded RNA-Binding Domain Protein

2005 • 537 citations

Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.

1991 • 504 citations

Polarization of both major body axes in Drosophila by gurken-torpedo signalling

1995 • 485 citations

Dicer is essential for formation of the heterochromatin structure in vertebrate cells

2004 • 484 citations

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila

1995 • 480 citations

The Human LINE-1 Retrotransposon Creates DNA Double-strand Breaks

2006 • 459 citations

Chk2 kinase — a busy messenger

2001 • 396 citations

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

2002 • 393 citations

FlyBase: genes and gene models

2004 • 383 citations

RISC Assembly Defects in the Drosophila RNAi Mutant armitage

2004 • 377 citations

Germ line and soma cooperate during oogenesis to establish the dorsoventral pattern of egg shell and embryo in Drosophila melanogaster

1987 • 373 citations

Regulation of the Drosophila segmentation gene hunchback by two maternal morphogenetic centres

1988 • 366 citations

Localization of vasa protein to the Drosophila pole plasm is independent of its RNA-binding and helicase activities

1994 • 328 citations

RNA interference is required for normal centromere function in fission yeast.

2003 • 316 citations

Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage

2004 • 305 citations

mei-W68 in Drosophila melanogaster encodes a Spo11 homolog: evidence that the mechanism for initiating meiotic recombination is conserved

1998 • 297 citations

vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development

1998 • 292 citations

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

1995 • 278 citations

Two mouse piwi-related genes: miwi and mili

2001 • 271 citations

DNA double-strand break-induced phosphorylation of Drosophila histone variant H2Av helps prevent radiation-induced apoptosis

2002 • 271 citations

A central role for microtubules in the differentiation of Drosophila oocytes

1993 • 252 citations

Identification and characterization of small RNAs involved in RNA silencing

2005 • 245 citations

The Drosophila SDE3 Homolog armitage Is Required for oskar mRNA Silencing and Embryonic Axis Specification

2004 • 242 citations

Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis

1999 • 213 citations

Human LINE-1 retrotransposon induces DNA damage and apoptosis in cancer cells

2006 • 211 citations

okra and spindle-B encode components of the RAD52 DNA repair pathway and affect meiosis and patterning in Drosophila oogenesis

1998 • 211 citations

The Role of the RNAi Machinery in Heterochromatin Formation

2005 • 208 citations

Drosophila Checkpoint Kinase 2 Couples Centrosome Function and Spindle Assembly to Genomic Integrity

2003 • 199 citations

In Vivo Analysis of Drosophila bicoid mRNA Localization Reveals a Novel Microtubule-Dependent Axis Specification Pathway

2001 • 194 citations

Large-scale chromatin structural domains within mitotic and interphase chromosomes in vivo and in vitro

1989 • 194 citations

Dissection of a Natural RNA Silencing Process in the Drosophila melanogaster Germ Line

2004 • 191 citations

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E

2002 • 184 citations

An essential role of DmRad51/SpnA in DNA repair and meiotic checkpoint control

2003 • 170 citations

Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases.

1995 • 156 citations

Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes

1997 • 154 citations

Oskar anchoring restricts pole plasm formation to the posterior of theDrosophilaoocyte

2002 • 147 citations

Activation of a Meiotic Checkpoint during Drosophila Oogenesis Regulates the Translation of Gurken through Chk2/Mnk

2002 • 143 citations

Dicer is required for chromosome segregation and gene silencing in fission yeast cells

2002 • 139 citations

Gamma radiation increases endonuclease-dependent L1 retrotransposition in a cultured cell assay

2006 • 137 citations

The RNA Interference Proteins and Vasa Locus are Involved in the Silencing of Retrotransposons in the Female Germline ofDrosophila melanogaster

2004 • 136 citations

Transcriptional activation of short interspersed elements by DNA-damaging agents

2000 • 132 citations

Relationship of DNA double-strand breaks to synapsis in Drosophila

2003 • 131 citations

DNA repair: Spot(light)s on chromatin

2001 • 131 citations

DNA damage activates transcription and transposition of yeast Ty retrotransposons

1989 • 129 citations

Drosophila argonaute-2 is required early in embryogenesis for the assembly of centric/centromeric heterochromatin, nuclear division, nuclear migration, and germ-cell formation

2005 • 119 citations

The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2.

1995 • 108 citations

Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect

2004 • 101 citations

Two retrotransposons maintain telomeres in Drosophila

2005 • 89 citations

Chapter 25 Immunofluorescence Analysis of the Cytoskeleton during Oogenesis and Early Embryogenesis

1994 • 86 citations

The Drosophila spn-D Gene Encodes a RAD51C-Like Protein That Is Required Exclusively During Meiosis

2003 • 82 citations

All Paired Up with No Place to Go: Pairing, Synapsis, and DSB Formation in a Balancer Heterozygote

2005 • 77 citations

A role of the Drosophila homeless gene in repression of Stellate in male meiosis

2001 • 76 citations

THE EFFECT OF mei-41 ON rDNA REDUNDANCY IN DROSOPHILA MELANOGASTER

1983 • 32 citations

Stellate repeats: targets of silencing and modules causing cis-inactivation and trans-activation.

2003 • 9 citations

Deleted Work

1955 • 0 citations

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