Increased proteinase expression during tumor progression of tissue inhibitor of metalloproteinases cell lines down-modulated for levels: a new transformation paradigm?

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

A Method for Isolation of Intact, Translationally Active Ribonucleic Acid

1983 • 1,469 citations

Hereditary cancer, oncogenes, and antioncogenes.

1985 • 1,261 citations

Structure and biological activity of basement membrane proteins

1989 • 967 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

Mechanisms of Tumor Progression

2010 • 608 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Tumor Suppressor Genes: The Puzzle and the Promise

1989 • 488 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Expression of extracellular matrix components is regulated by substratum.

1990 • 345 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Molecular cloning of the cDNA for a growth factor-inducible gene with strong homology to S-100, a calcium-binding protein.

1986 • 265 citations

The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors.

1986 • 260 citations

Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis

1989 • 238 citations

Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene.

1985 • 209 citations

Elevated expression of secreted phosphoprotein I (osteopontin, 2ar) as a consequence of neoplastic transformation.

1989 • 205 citations

The identification of the major excreted protein (MEP) from a transformed mouse fibroblast cell line as a catalytically active precursor form of cathepsin L

1987 • 172 citations

Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion.

1989 • 158 citations

A growth-responsive gene (16C8) in normal mouse fibroblasts homologous to a human collagenase inhibitor with erythroid-potentiating activity: evidence for inducible and constitutive transcripts

1986 • 155 citations

Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.

1987 • 151 citations

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

1987 • 127 citations

Secreted phosphoprotein mrna is induced during multi‐stage carcinogenesis in mouse skin and correlates with the metastatic potential of murine fibroblasts

1990 • 118 citations

Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells.

1989 • 103 citations

Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane

1988 • 102 citations

Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases

1989 • 97 citations

Mechanism for selective secretion of a lysosomal protease by transformed mouse fibroblasts

1989 • 79 citations

Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.

1990 • 52 citations

Mechanisms of Cellular Invasiveness: A Comparison of Amnion Invasion In Vitro and Metastatic Behavior In Vivo

1989 • 42 citations

On the use of anti-sense RNA: down-regulation of mRNA encoding a metalloproteinase inhibitor.

1987 • 24 citations

Cancer progression: The ultimate challenge

1989 • 14 citations

Oncogenic consequences of down-modulating TIMP expression in 3T3 cells with antisense RNA.

1992 • 8 citations