Integrated approach for evaluating species and interindividual differences in responsiveness to dioxins and structural analogs.

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

1991 • 963 citations

Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P45 0IA1 gene

1990 • 487 citations

Genetic and Molecular Aspects of 2,3,7,8-Tetra-Chlorodibenzo-P-Dioxin Action

1990 • 446 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs

1978 • 387 citations

Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

1980 • 374 citations

Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analyzed in cryopreserved lymphocytes.

1982 • 269 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

1975 • 238 citations

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA.

1990 • 189 citations

Human CYP1A1 gene: cosegregation of the enzyme inducibility phenotype and an RFLP.

1991 • 176 citations

TEN-YEAR MORTALITY STUDY OF THE POPULATION INVOLVED IN THE SEVESO INCIDENT IN 1976

1989 • 154 citations

Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

1991 • 148 citations

Suppression of B cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1986 • 140 citations

Photoaffinity labeling of the Ah receptor.

1986 • 139 citations

Long-term carcinogenesis studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexachlorodibenzo-p-dioxins

1991 • 109 citations

Selective effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and corticosteroid on in vitro lymphocyte maturation.

1988 • 101 citations

A review of the genetic toxicology of chlorinated dibenzo-p-dioxins

1977 • 100 citations

alpha-Naphthoflavone antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced murine lymphocyte ethoxyresorufin-O-deethylase activity and immunosuppression.

1987 • 97 citations

Is environmental carcinogenesis modulated by host polymorphism?

1991 • 96 citations

Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah locus

1990 • 85 citations

Purification and N-terminal amino acid sequence of the Ah receptor from the C57BL/6J mouse.

1991 • 83 citations

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice

1991 • 76 citations

Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo--dioxin

1974 • 74 citations

Dioxins and the ah receptor

1989 • 74 citations

Dioxin Risks Revisited

1991 • 74 citations

Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system

1991 • 71 citations

Placental markers of human exposure to polychlorinated biphenyls and polychlorinated dibenzofurans.

1987 • 68 citations

Variations in extent of aryl hydrocarbon hydroxylase induction in cultured human lymphocytes.

1973 • 61 citations

Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor.

1991 • 56 citations

Induction of 7-ethoxycoumarin O-deethylase activity in cultured human epithelial cells by 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD): Evidence for TCDD receptor

1983 • 47 citations

An in vitro model for studying the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin to human thymus

1987 • 40 citations

Relationships among benzo(a)pyrene metabolism, benzo(a)pyrene-diol-epoxide:DNA adduct formation, and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers.

1989 • 39 citations

The Ah receptor, cytochrome P450IA1 mRNA induction, and aryl hydrocarbon hydroxylase in a human lymphoblastoid cell line

1991 • 38 citations

Factors influencing the induction of DNA single strand breaks in rats by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

1989 • 38 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulation of tyrosine phosphorylation in B lymphocytes: potential role in immunosuppression.

1991 • 37 citations

Genetic And Molecular Aspects Of 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Action

1990 • 31 citations

Mechanism of action of peptide hormones and catecholamines

1985 • 27 citations

Important aspects of the evidence for TCDD carcinogenicity in man.

1993 • 26 citations

Receptor-mediated carcinogenesis.

1992 • 24 citations

Genetically mediated induction of aryl hydrocarbon hydroxylase activity in human lymphoblastoid cells by polychlorinated dibenzofuran isomers and 2,3,7,8-tetrachlorodibenzo-p-dioxin

1985 • 23 citations

Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors

1991 • 21 citations

Mechanisms of dioxin tumor promotion: Implications for risk assessment

1992 • 12 citations

Human risks from 2,3,7,8-tetrachlorodibenzo-p-dioxin and hexachlorodibenzo-p-dioxins.

1990 • 11 citations

Placental markers of human exposure to polychlorinated dibenzofurans and polychlorinated biphenyls: implications for risk assessment.

1990 • 7 citations

Important Aspects of the Evidence for TCDD Carcinogenicity in Man

1993 • 5 citations

Receptor-Mediated Carcinogenesis

2010 • 1 citations