Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Cancer Statistics, 2006

2006 • 5,351 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer

2003 • 3,194 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer

2005 • 1,985 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells

2003 • 1,252 citations

Cancer incidence and mortality in Europe, 2004

2005 • 1,218 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma

1996 • 1,110 citations

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

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Colorectal cancer

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Celecoxib for the Prevention of Sporadic Colorectal Adenomas

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Cancer incidence and mortality in Europe

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PROSTAGLANDINS AND CANCER

2005 • 857 citations

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1997 • 734 citations

Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice

2001 • 585 citations

Prostaglandin E2 Induces FOXP3 Gene Expression and T Regulatory Cell Function in Human CD4+ T Cells

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Generation of Human Cytotoxic T Cells Specific for Human Carcinoembryonic Antigen Epitopes From Patients Immunized With Recombinant Vaccinia-CEA Vaccine

1995 • 506 citations

Tumor Cyclooxygenase-2/Prostaglandin E2–Dependent Promotion of FOXP3 Expression and CD4+CD25+ T Regulatory Cell Activities in Lung Cancer

2005 • 491 citations

CD4⁺CD25⁺ regulatory T cells in patients with gastrointestinal malignancies

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Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression

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Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.

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Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.

1999 • 363 citations

Transient regulatory T-cells: A state attained by all activated human T-cells

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A Large Cohort Study of Long-Term Daily Use of Adult-Strength Aspirin and Cancer Incidence

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NSAIDs and Cancer Prevention: Targets Downstream of COX-2

2006 • 298 citations

FOXP3+CD4+CD25+ Adaptive Regulatory T Cells Express Cyclooxygenase-2 and Suppress Effector T Cells by a Prostaglandin E2-Dependent Mechanism

2006 • 239 citations

CD4+CD25+FOXP3+ Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer

2006 • 213 citations

Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen.

1997 • 210 citations

Depletion of CD4+CD25+ Regulatory Cells Augments the Generation of Specific Immune T Cells in Tumor-Draining Lymph Nodes

2002 • 206 citations

Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.

2007 • 171 citations

Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.

2002 • 142 citations

Identification of HLA-A3-restricted cytotoxic T lymphocyte epitopes from carcinoembryonic antigen and HER-2/neu by primary in vitro immunization with peptide-pulsed dendritic cells.

1999 • 127 citations

In situ analysis of FOXP3+ regulatory T cells in human colorectal cancer

2006 • 122 citations

Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumor-reactive cytotoxic T lymphocyte

1999 • 101 citations

Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity

2005 • 90 citations

Prospective Study of Urinary Prostaglandin E₂ Metabolite and Colorectal Cancer Risk

2006 • 90 citations

The role of cytokines in immunological tolerance: potential for therapy

2000 • 75 citations

Cyclooxygenase 2 Inhibition Promotes IFN-γ-Dependent Enhancement of Antitumor Responses

2005 • 69 citations

CD4(+) T cells from healthy subjects and colon cancer patients recognize a carcinoembryonic antigen-specific immunodominant epitope.

2003 • 53 citations

Monoclonal antibody EG2 does not provide reliable immunohistochemical discrimination between resting and activated eosinophils

1994 • 48 citations

Strategies for cancer therapy using carcinoembryonic antigen vaccines

2000 • 38 citations

Immunochemical measurement of prostaglandin or prostaglandin-like activity from normal and neoplastic cultured tissue.

1971 • 34 citations

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