Chapter III. 1. Mutations in human breast cancer cells: Dominantly-acting oncogenes and tumor suppressor genes suggest strategies for targeted interference

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

Epidermal growth factor.

1990 • 1,645 citations

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1988 • 1,160 citations

Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes

1984 • 906 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

The Product of the Human c- erb B-2 Gene: a 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity

1986 • 805 citations

The role of gene dosage and genetic transpositions in carcinogenesis

1981 • 670 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor.

1979 • 530 citations

A non-AUG translational initiation in c-myc exon 1 generates an N-terminally distinct protein whose synthesis is disrupted in Burkitt's lymphomas

1988 • 481 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.

1986 • 413 citations

Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene

1989 • 395 citations

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13).

1986 • 371 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells

1989 • 355 citations

Amplification of the neu (c-erbB-2) oncogene in human mammmary tumors is relatively frequent and is often accompanied by amplification of the linked c-erbA oncogene.

1987 • 335 citations

Reduction to Homozygosity of Genes on Chromosome 11 in Human Breast Neoplasia

1987 • 329 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Negative autoregulation of c-myc transcription.

1990 • 247 citations

ALLELE LOSS ON SHORT ARM OF CHROMOSOME 17 IN BREAST CANCERS

1988 • 236 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription.

1988 • 196 citations

Amplification of the int-2 gene in primary human breast tumors.

1988 • 172 citations

Mutations in Human Breast Cancer: An Overview

1989 • 155 citations

Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis.

1988 • 149 citations

Oncogenic Activation of p185^neu Stimulates Tyrosine Phosphorylation In Vivo

1988 • 142 citations

Loss of heterozygosity on chromosomes 17 and 18 in breast carcinoma: two additional regions identified.

1990 • 123 citations

The int genes in mammary tumorigenesis and in normal development

1988 • 117 citations

The amplification unit on chromosome 11q13 in aggressive primary human breast tumors entails the bcl-1, int-2 and hst loci.

1989 • 114 citations

DNA replication origin and transcriptional enhancer in c-myc gene share the c-myc protein binding sequences.

1989 • 106 citations

The ninth Gordon Hamilton-Fairley memorial lecture: Hereditary cancers: clues to mechanisms of carcinogenesis

1989 • 105 citations

Presence of Two Members of c-erbA Receptor Gene Family (c-erbAbeta and c-erbA2) in Smallest Region of Somatic Homozygosity on Chromosome 3p21-p25 in Human Breast Carcinoma

1989 • 99 citations

In situ c-myc expression and genomic status of the c-myc locus in infiltrating ductal carcinomas of the breast.

1988 • 90 citations

Oncogenic activation of p185neu stimulates tyrosine phosphorylation in vivo.

1988 • 87 citations

In Vivo Amplification and Rearrangement of c-myc Oncogene in Human Breast Tumors

1988 • 84 citations

Molecular mechanisms of oncogenesis.

1989 • 84 citations

Genetic alterations in primary breast cancer

1989 • 49 citations

The Therapeutic Implications of the Molecular Biology of Breast Cancer

1991 • 6 citations