Acute peripheral inflammation induces moderate glial activation and spinal IL-1β expression that correlates with pain behavior in the rat

Microglia: a sensor for pathological events in the CNS

1996 • 4,309 citations

The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats

1977 • 2,494 citations

Cytokines and the nervous system II: actions and mechanisms of action

1995 • 928 citations

Cytokines and the nervous system I: expression and recognition

1995 • 745 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 • 667 citations

Immune activation: the role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states

1995 • 656 citations

Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

1995 • 573 citations

A neuromodulatory role of interleukin-1β in the hippocampus

1998 • 481 citations

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

1998 • 452 citations

The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior

1999 • 435 citations

Staining of glial fibrillary acidic protein (GFAP) in lumbar spinal cord increases following a sciatic nerve constriction injury

1991 • 396 citations

Interleukin-6-Mediated Hyperalgesia/Allodynia and Increased Spinal IL-6 Expression in a Rat Mononeuropathy Model

1996 • 366 citations

Central neuron–glial and glial–glial interactions following axon injury

1998 • 350 citations

Evidence for the involvement of spinal cord glia in subcutaneous formalin induced hyperalgesia in the rat

1997 • 345 citations

The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat

1994 • 340 citations

Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat

1997 • 338 citations

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

1998 • 323 citations

Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior

1998 • 281 citations

Intravenous lipopolysaccharide induces cyclooxygenase 2-like immunoreactivity in rat brain perivascular microglia and meningeal macrophages

1997 • 279 citations

Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy

1997 • 247 citations

Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor

1995 • 214 citations

The Brain's Immune System

1995 • 170 citations

Astrocytes as mediators of immune and inflammatory responses in the CNS.

1998 • 169 citations

Increase of interleukin-1β mRNA and protein in the spinal cord following experimental traumatic injury in the rat

1997 • 160 citations

GFAP Expression in Lumbar Spinal Cord of Naive and Neuropathic Rats Treated with MK-801

1994 • 141 citations

Global Forebrain Ischemia Results in Differential Cellular Expression of Interleukin-1β (IL-1β) and its Receptor at mRNA and Protein Level

1997 • 131 citations

Optimal scoring strategies and weights for the formalin test in rats

1997 • 110 citations

Differential activation of microglia and astrocytes following trimethyl tin-induced neurodegeneration

1996 • 108 citations

Substance P and Histamine Induce Interleukin‐6 Expression in Human Astrocytoma Cells by a Mechanism Involving Protein Kinase C and Nuclear Factor‐IL‐6

1998 • 62 citations

Distribution of interleukin 1β immunoreactivity within the porcine hypothalamus

1993 • 42 citations