Inhibition of Cryptococcus neoformans replication by nitrogen oxides supports the role of these molecules as effectors of macrophage-mediated cytostasis

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells.

1982 • 349 citations

Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

1988 • 337 citations

Virulence of Cryptococcus neoformans. Regulation of capsule synthesis by carbon dioxide.

1985 • 320 citations

Reactions of nitric oxide coordinated to transition metals

1979 • 299 citations

Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

1988 • 243 citations

Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages

1984 • 183 citations

Synthesis of nitrogen oxides from L-arginine by macrophage cytosol: Requirement for inducible and constitutive components

1989 • 148 citations

Human Alveolar and Peritoneal Macrophages Mediate Fungistasis Independently of L-Arginine Oxidation to Nitrite or Nitrate

1990 • 136 citations

Fungicidal activity of IFN-gamma-activated macrophages. Extracellular killing of Cryptococcus neoformans.

1989 • 131 citations

The inorganic chemistry of nitrogen

1964 • 96 citations

Differential stimulation of murine resident peritoneal cells by selectively opsonized encapsulated and acapsular Cryptococcus neoformans

1988 • 95 citations

Mitochondrial iron loss from leukemia cells injured by macrophages. A possible mechanism for electron transport chain defects.

1988 • 85 citations

Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect

1977 • 84 citations

Macrophage-mediated fungistasis in vitro: requirements for intracellular and extracellular cytotoxicity.

1986 • 79 citations