Regulation of G proteins by chronic morphine in the rat locus coeruleus

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

Mu and delta receptors belong to a family of receptors that are coupled to potassium channels.

1987 • 616 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Morphine receptors as regulators of adenylate cyclase activity.

1975 • 529 citations

Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats

1973 • 523 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein.

1984 • 411 citations

Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins.

1986 • 380 citations

Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus.

1988 • 280 citations

Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture.

1987 • 266 citations

Cellular mechanisms of opioid tolerance: studies in single brain neurons.

1987 • 260 citations

Multiple Mechanisms of withdrawal from Opioid Drugs

1984 • 241 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Chronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.

1988 • 228 citations

Common α2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices

1987 • 202 citations

Cellular site of opiate dependence

1980 • 201 citations

Demonstration and Characterization of Opiate Inhibition of the Striatal Adenylate Cyclase

1981 • 149 citations

Morphine tolerance and dependence in the locus coeruleus: Single cell studies in brain slices

1983 • 139 citations

Opiate Receptor‐Mediated Inhibition of Adenylate Cyclase in Rat Striatal Plasma Membranes

1982 • 121 citations

Opiate activation of potassium conductance inhibits calcium action potentials in rat locus coeruleus neurones

1983 • 104 citations

Actions of opiates upon single unit activity in the cortex of naive and tolerant rats

1976 • 86 citations

Receptor-regulated G proteins

1986 • 82 citations

Pertussis toxin blocks depressant effects of opioid, monoaminergic and muscarinic agonists on dorsal-horn network responses in spinal cord-ganglion cultures

1987 • 67 citations

Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma X glioma NG108-15 hybrid cells.

1985 • 60 citations

Excitation of locus coeruleus neurons by an adenoine 3′,5′‐cyclic monophosphate‐activated inward current: Extracellular and intracellular studies in rat brain slices

1987 • 55 citations

Isoarecolone can inhibit nicotine binding and produce nicotine-like discriminative stimulus effects in rats

1987 • 54 citations

The biochemical basis of neuropharmacology

1987 • 50 citations

Pertussis toxin treatment modifies opiate action in the rat brain striatum

1985 • 48 citations

Morphine inhibition of calcium fluxes, neurotransmitter release and protein and lipid phosphorylation in brain slices and synaptosomes

1986 • 32 citations

Morphine tolerance and dependence: sensitivity of caudate nucleus neurons

1979 • 27 citations