Transforming Growth Factor-Beta Expression in Mouse Lung Carcinogenesis

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Genomic sequencing.

1984 • 8,343 citations

Handbook of experimental pharmacology

1984 • 1,599 citations

Synthesis of messenger RNAs for transforming growth factors alpha and beta and the epidermal growth factor receptor by human tumors.

1987 • 895 citations

The Transforming Growth Factor-βs

1991 • 882 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors

1987 • 710 citations

The TGF-β family and its composite receptors

1994 • 539 citations

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

1987 • 498 citations

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts.

1987 • 467 citations

Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.

1990 • 449 citations

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability.

1995 • 445 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse.

1989 • 338 citations

T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.

1987 • 337 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

5462925 Transforming growth factor beta2,3

1996 • 255 citations

Murine Transforming Growth Factor-β2 cDNA Sequence and Expression in Adult Tissues and Embryos

1989 • 220 citations

Missense mutations of the transforming growth factor beta type II receptor in human head and neck squamous carcinoma cells.

1995 • 216 citations

Inhibition of growth by transforming growth factor-beta following fusion of two nonresponsive human carcinoma cell lines. Implication of the type II receptor in growth inhibitory responses.

1992 • 176 citations

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

1991 • 174 citations

Expression of transforming growth factor alpha in normal human adult kidney and enhanced expression of transforming growth factors alpha and beta 1 in renal cell carcinoma.

1989 • 143 citations

Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma.

1992 • 135 citations

Sequence and expression of a cDNA encoding MyD118: a novel myeloid differentiation primary response gene induced by multiple cytokines.

1991 • 133 citations

Increased secretion of type beta transforming growth factor accompanies viral transformation of cells.

1985 • 132 citations

Regulation of growth and differentiation of human keratinocytes by type beta transforming growth factor and epidermal growth factor.

1987 • 124 citations

Transcripts for transforming growth factors in human breast cancer: clinical correlates

1990 • 107 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

TGFβ₁ and TGFβ₂ are potential growth regulators for low‐grade and malignant gliomas in vitro: Evidence in support of an autocrine hypothesis

1991 • 107 citations

Ki-ras and p53 mutations are early and late events, respectively, in urethane-induced pulmonary carcinogenesis in A/J mice

1996 • 103 citations

Loss of functional cell surface transforming growth factor β (TGF-β) type 1 receptor correlates with insensitivity to TGF-β in chronic lymphocytic leukemia

1997 • 101 citations

Expression of TGF‐β and procollagen type I and type III in human gastric carcinomas

1989 • 99 citations

At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice

1994 • 84 citations

Transforming Growth Factor‐Beta

1991 • 82 citations

Cloning by Polymerase Chain Reaction of a New Mouse TGF-β, mTGF-β3

1990 • 70 citations

A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.

1994 • 65 citations

Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.

1991 • 64 citations

Expression of transforming growth factor beta ligand and receptor messenger RNAs in lung cancer cell lines.

1995 • 55 citations

Growth suppression by transforming growth factor β1 of human small-cell lung cancer cell lines is associated with expression of the type II receptor

1994 • 47 citations

Expression of transforming growth factor β (TGFβ) receptors and expression of TGFβ1, TGFβ2 and TGFβ3 in human small cell lung cancer cell lines

1993 • 46 citations

Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells.

1988 • 42 citations

Hormonal regulation of transforming growth factor β-2 expression in human prostate cancer

1993 • 35 citations

Multimodality Therapy for Stage IIIA (N2) Lung Cancer

1993 • 29 citations

Pattern of Growth Factor, Proto-Oncogene and Carcinoembryonic Antigen Gene Expression in Human Colorectal Carcinoma Cell Lines

1992 • 11 citations

Expression of Transforming Growth Factor-β1, 2, and 3 m RNAand Protein in Human Cancers

1994 • 8 citations