Genetics of Experimental Autoimmune Encephalomyelitis

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

A genetic map of the mouse suitable for typing intraspecific crosses.

1992 • 1,114 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

The T Lymphocyte in Experimental Allergic Encephalomyelitis

1990 • 1,005 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE).

1996 • 985 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

Interleukin-12 and its role in the generation of TH1 cells

1993 • 869 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

A full genome search in multiple sclerosis

1996 • 666 citations

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

1996 • 650 citations

A Population-Based Study of Multiple Sclerosis in Twins

1986 • 644 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS

1933 • 629 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease.

1994 • 599 citations

Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes.

1981 • 592 citations

Genetic Control of Autoimmune Diabetes in the Nod Mouse

1995 • 586 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12.

1995 • 560 citations

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy

1988 • 555 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

A Genetic Linkage Map of the Mouse: Current Applications and Future Prospects

1993 • 549 citations

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

1994 • 543 citations

TRANSFER OF ALLERGIC ENCEPHALOMYELITIS IN RATS BY MEANS OF LYMPH NODE CELLS

1960 • 540 citations

Functional diversity of T lymphocytes due to secretion of different cytokine patterns

1991 • 530 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Polygenic control of susceptibility to murine systemic lupus erythematosus

1994 • 484 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma.

1988 • 432 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

Genetic Control of the Antibody Response: Relationship between Immune Response and Histocompatibility ( H-2 ) Type

1969 • 425 citations

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1995 • 422 citations

Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?

1988 • 404 citations

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

1989 • 372 citations

Regulation of Experimental Autoimmune Encephalomyelitis by Natural Killer (NK) Cells

1997 • 360 citations

Lupus susceptibility loci in New Zealand mice.

1994 • 359 citations

Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8 ^-/- Mice

1992 • 359 citations

GENETIC CONTROL OF THE IMMUNE RESPONSE

1972 • 355 citations

A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity

1994 • 347 citations

Review: cytokines and the pathogenesis of multiple sclerosis

1996 • 331 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

Increased interleukin 12 production in progressive multiple sclerosis: Induction by activated CD4⁺T cells via CD40 ligand

1997 • 313 citations

Multiple Sclerosis: Association with HL—A3

1972 • 305 citations

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

1992 • 299 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis

1997 • 267 citations

ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS

1962 • 264 citations

Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

1997 • 239 citations

Experimental allergic encephalomyelitis: successful treatment in vivo with a monoclonal antibody that recognizes T helper cells.

1984 • 222 citations

A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex

1989 • 219 citations

Genetic dissection of autoimmune type I diabetes in the BB rat

1992 • 218 citations

A putative vulnerability locus to multiple sclerosis maps to 5p14–p12 in a region syntenic to the murine locus Eae2

1996 • 209 citations

Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.

1997 • 204 citations

Isoallergic Encephalomyelitis and Radiculitis in Guinea Pigs After One Injection of Brain and Mycobacteria in Water-in-Oil Emulsion

1947 • 199 citations

Tumor Necrosis Factor α and Lymphotoxin α Are Not Required for Induction of Acute Experimental Autoimmune Encephalomyelitis

1997 • 197 citations

A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis

1997 • 187 citations

IL-12 unmasks latent autoimmune disease in resistant mice.

1996 • 182 citations

Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis

1995 • 181 citations

CD4+ suppressor cells inhibit the function of effector cells of experimental autoimmune encephalomyelitis through a mechanism involving transforming growth factor-beta.

1991 • 175 citations

Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice.

1988 • 172 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Acute autoimmune encephalomyelitis in mice. II. Susceptibility is controlled by the combination of H-2 and histamine sensitization genes.

1982 • 162 citations

Differential tumor necrosis factor alpha expression by astrocytes from experimental allergic encephalomyelitis-susceptible and -resistant rat strains.

1991 • 157 citations

LINKAGE OF SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS TO THE MAJOR HISTOCOMPATIBILITY LOCUS IN THE RAT

1973 • 154 citations

Major histocompatibility complex-linked control of the murine immune response to myelin basic protein.

1985 • 154 citations

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

1988 • 154 citations

Genetic Control of Susceptibility to Experimental Allergic Encephalomyelitis in Rats

1973 • 152 citations

The germline repertoire of T cell receptor β-chain genes in patients with chronic progressive multiple sclerosis

1989 • 147 citations

Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition.

1985 • 147 citations

Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner.

1995 • 146 citations

EXPERIMENTAL AUTOIMMUNE ENCEPHALO‐MYELITIS IN MICE: GENETIC CONTROL OF SUSCEPTIBILITY*

1976 • 142 citations

Increased severity of experimental autoimmune encephalomyelitis, chronic macrophage/microglial reactivity, and demyelination in transgenic mice producing tumor necrosis factor‐α in the central nervous system

1997 • 142 citations

Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon‐γ

1996 • 141 citations

Crosses of NOD Mice With the Related NON Strain: A Polygenic Model for IDDM

1995 • 140 citations

Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J x PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant.

1983 • 137 citations

Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage.

1992 • 135 citations

Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice.

1992 • 134 citations

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein.

1996 • 134 citations

Reduced Incidence and Severity of Antigen-induced Autoimmune Diseases in Mice Lacking Interferon Regulatory Factor-1

1997 • 131 citations

Multiple Sclerosis in Twins and Their Relatives

1966 • 130 citations

Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1.

1997 • 129 citations

Transfėr of Allergic Encephalomyelitis by Lymph Node Cells in Inbred Guinea Pigs

1961 • 128 citations

Mapping of the IDDM Locus Idd3 to a 0.35-cM Interval Containing the Interleukin-2 Gene

1997 • 128 citations

A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.

1988 • 126 citations

Experimental Allergic Encephalomyelitis in Inbred and Outbred Mice

1973 • 121 citations

Multiple Sclerosis and High Incidence of a B Lymphocyte Antigen

1976 • 120 citations

EXPERIMENTAL DISSEMINATED ENCEPHALOMYELITIS IN WHITE MICE

1949 • 118 citations

Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice.

1996 • 115 citations

The immunopathology of experimental allergic encephalomyelitis. I. Quantitative analysis of inflammatory cells in situ.

1984 • 111 citations

Experimental autoimmune encephalomyelitis in IL-4-deficient mice

1997 • 111 citations

Genetic analysis of experimental allergic encephalomyelitis in mice.

1995 • 111 citations

CD4⁺ suppressor cells of autoimmune encephalomyelitis respond to T cell receptor‐associated determinants on effector cells by interleukin‐4 secretion

1992 • 108 citations

Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse.

1982 • 95 citations

Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis.

1997 • 92 citations

Encephalitogenic Epitopes of Myelin Basic Protein

1989 • 89 citations

Genetic Control of Susceptibility to Experimental Allergic Encephalomyelitis and the Ag-B Locus of Rats

1975 • 89 citations

Induction of experimental allergic encephalomyelitis in genetically resistant strains of mice

1980 • 81 citations

Interferon γ- and interleukin-4-secreting cells in multiple sclerosis

1993 • 80 citations

Susceptibility to multiple sclerosis is associated with the proximal immunoglobulin heavy chain variable region.

1991 • 79 citations

Exposure to T helper 2 cytokines in vivo before encounter with antigen selects for T helper subsets via alterations in antigen-presenting cell function.

1996 • 71 citations

Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects.

1988 • 70 citations

Multiple sclerosis in a nationwide series of twins

1987 • 69 citations

DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis

1990 • 67 citations

Simple Method for Enhancing Development of Acute Disseminated Encephalomyelitis in Mice.

1955 • 67 citations

Experimental allergic encephalomyelitis (EAE) in mice: primary control of EAE susceptibility is outside the H-2 complex.

1982 • 61 citations

HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees.

1980 • 58 citations

Concomitant detection of changes in myelin basic protein and permeability of blood-spinal cord barrier in acute experimental autoimmune encephalomyelitis by electroimmunoblotting

1985 • 52 citations

Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.

1996 • 52 citations

A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains

1992 • 47 citations

Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains

1987 • 47 citations

Linkage of severity of experimental allergic encephalomyelitis to the rat major histocompatibility locus.

1980 • 45 citations

Experimental allergic encephalomyelitis in congenic strains of mice

1974 • 39 citations

Association between susceptibility to experimental allergic encephalomyelitis and the major histocompatibility system in congenic rat strains.

1978 • 38 citations

Host genetic regulation of acute MHV-4 viral encephalomyelitis and acute experimental autoimmune encephalomyelitis in (BALB/cKe × SJL/J) recombinant-inbred mice

1985 • 38 citations

Production of experimental allergic encephalomyelitis with the aid of pertussigen in mouse strains considered genetically resistant

1984 • 34 citations

Encephalomyelitis in the Rat Following Intracutaneous Injection of Central Nervous System Tissue with Adjuvant

1952 • 31 citations

Genetic differences in the T cell receptor alleles of LEW rats and their encephalomyelitis‐resistant derivative, LER, and their impact on the inheritance of EAE resistance

1991 • 30 citations

Genetic control of resistance to clinical EAE accompanied by histological symptoms

1990 • 24 citations

Polygenic control of experimental allergic encephalomyelitis in Biozzi ABH and BALB/c mice

1997 • 24 citations

Genetic resistance to the induction of experimental allergic encephalomyelitis in Lewis rats. I. Genetic analysis of an apparent mutant strain with phenotypic resistance to experimental allergic encephalomyelitis.

1981 • 23 citations

Role of Heredity in Experimental Disseminated Encephalomyelitis in Mice

1954 • 21 citations

HLA genetic determinants in familial MS

1987 • 20 citations

Biological Properties and Variations of Reactions of the Encephalitogenic Agent in Nervous Tissues

1953 • 18 citations

Genetic resistance in experimental autoimmune encephalomyelitis

1989 • 15 citations

Minor lymphocyte stimulating (Mls) gene products in mice influence their genetic resistance or susceptibility to induction of autoimmune encephalomyelitis

1990 • 12 citations

DISSOCIATION BETWEEN HISTOLOGICAL AND CLINICAL SIGNS OF EXPERIMENTAL AUTO‐IMMUNE ENCEPHALOMYELITIS

1986 • 10 citations

Influence of T-cell receptor genes on chronic experimental autoimmune encephalomyelitis

1993 • 9 citations

Rat Experimental Autoimmune Encephalomyelitis

1994 • 7 citations

Experimental autoimmune encephalomyelitis in hybrids between Lewis and Brown Norway rats

1982 • 5 citations

Deleted Work

1955 • 0 citations