Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
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References (79)
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
1982 • 3,563 citations
Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.
1959 • 1,751 citations
Down's syndrome
2003 • 1,286 citations
PSD-95 Involvement in Maturation of Excitatory Synapses
2000 • 1,238 citations
Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity
2001 • 1,236 citations
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
1985 • 1,125 citations
The pyramidal neuron of the cerebral cortex: Morphological and chemical characteristics of the synaptic inputs
1992 • 954 citations
A mouse model for Down syndrome exhibits learning and behaviour deficits
1995 • 891 citations
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
2002 • 806 citations
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
2000 • 792 citations
Regulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
2001 • 685 citations
Inactivity Produces Increases in Neurotransmitter Release and Synapse Size
2001 • 620 citations
The Vesicular GABA Transporter, VGAT, Localizes to Synaptic Vesicles in Sets of Glycinergic as Well as GABAergic Neurons
1998 • 601 citations
A Prospective Study of Alzheimer Disease in Down Syndrome
1989 • 550 citations
Accessory factors in clathrin-dependent synaptic vesicle endocytosis
2000 • 513 citations
The Neuropsychology of Down Syndrome: Evidence for Hippocampal Dysfunction
2003 • 508 citations
Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome
2004 • 462 citations
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways
2000 • 459 citations
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome
1996 • 445 citations
Neuroanatomy of Down’s Syndrome: A High-Resolution MRI Study
2001 • 430 citations
Principles and Practices of Unbiased Stereology: An Introduction for Bioscientists
2002 • 409 citations
Dynamin and its partners: a progress report
1998 • 403 citations
Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP
2001 • 383 citations
The Neuronal Rho-GEF Kalirin-7 Interacts with PDZ Domain–Containing Proteins and Regulates Dendritic Morphogenesis
2001 • 375 citations
Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
2001 • 336 citations
Synaptic activation of kainate receptors on hippocampal interneurons
1998 • 316 citations
GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells
1998 • 316 citations
Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative golgi study
1981 • 300 citations
Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis
2005 • 295 citations
Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study
1972 • 286 citations
Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study
1976 • 283 citations
Coupling actin dynamics and membrane dynamics during endocytosis
2002 • 280 citations
Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
2000 • 276 citations
Dendritic atrophy in children with Down's syndrome
1986 • 275 citations
A behavioral assessment of Ts65Dn mice: a putative Down syndrome model
1995 • 246 citations
Loss of Cholinergic Phenotype in Basal Forebrain Coincides with Cognitive Decline in a Mouse Model of Down's Syndrome
2000 • 227 citations
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome
1997 • 225 citations
THE DENSITY OF SYNAPSES AND NEURONS IN NORMAL, MENTALLY DEFECTIVE AND AGEING HUMAN BRAINS
1975 • 223 citations
Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
2003 • 210 citations
Postsynaptic targets of somatostatin-immunoreactive interneurons in the rat hippocampus
1999 • 206 citations
Molecular mechanisms of CNS synaptogenesis
2002 • 204 citations
Abnormalities of the nucleus basalis in Down's syndrome
1985 • 199 citations
Quantitative fine-structural analysis of olfactory cortical synapses
1999 • 198 citations
Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study
2001 • 198 citations
Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months.
1990 • 198 citations
Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus
1990 • 194 citations
Regulation of Tiam1–Rac signalling
2003 • 193 citations
Down's syndrome
1984 • 191 citations
Synapse-Associated Protein-97 Isoform-Specific Regulation of Surface AMPA Receptors and Synaptic Function in Cultured Neurons
2003 • 188 citations
Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome
1980 • 185 citations
Regulating the actin cytoskeleton during vesicular transport
2002 • 182 citations
Some assembly required: the development of neuronal synapses
2003 • 181 citations
The absence of a major Ca 2+ signaling pathway in GABAergic neurons of the hippocampus
1998 • 181 citations
Genetic Dissection of Region Associated with Behavioral Abnormalities in Mouse Models for Down Syndrome
2000 • 170 citations
Motor dysfunction in a mouse model for Down syndrome
1999 • 166 citations
Impaired short- and long-term memory in Ts65Dn mice, a model for Down syndrome
1998 • 163 citations
Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome
1998 • 149 citations
Alterations of Neocortical Pyramidal Cell Phenotype in the Ts65Dn Mouse Model of Down Syndrome: Effects of Environmental Enrichment
2003 • 148 citations
Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system
2003 • 132 citations
Normal and Aberrant Neuronal Development in the Cerebral Cortex of Human Fetus and Young Infant
1975 • 130 citations
Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice
2000 • 127 citations
Dendritic and histochemical development and ageing in patients with Down's syndrome
1994 • 123 citations
Spatial memory deficits in segmental trisomic Ts65Dn mice
1996 • 121 citations
Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
2001 • 113 citations
Dynamin Is a Minibrain Kinase/Dual Specificity Yak1-related Kinase 1A Substrate
2002 • 104 citations
Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice
1998 • 100 citations
Dimensions and density of dendritic spines from rat dentate granule cells based on reconstructions from serial electron micrographs
1997 • 86 citations
Distribution of GABAergic synapses and their targets in the dentate gyrus of rat: a quantitative immunoelectron microscopic analysis.
1993 • 83 citations
Evidence of Arrest of Neurogenesis and Synaptogenesis in Brains of Patients with Down's Syndrome
1984 • 79 citations
Reciprocal relationship between size of postsynaptic densities and their number: Constancy in contact area
1984 • 68 citations
A simple dot-immunobinding assay for quantification of synaptophysin-like immunoreactivity in human brain.
1994 • 63 citations
Axon arbors and synaptic connections of a vulnerable population of interneurons in the dentate gyrus in vivo
2002 • 62 citations
Mitogenesis and endocytosis: What's at the INTERSECTIoN?
2001 • 53 citations
Robust synaptic plasticity of striatal cells following partial deafferentation
1990 • 48 citations
Down Syndrome in Neurobiological Perspective: An Emphasis on Spatial Cognition
1993 • 46 citations
Behavioral phenotype of individuals with Down syndrome
2000 • 40 citations
Quantitative analysis of immunofluorescence and lipofuscin distribution in human cortical areas by dual-channel confocal laser scanning microscopy
1996 • 26 citations
Use-dependent inhibition of dendritic spines
2002 • 16 citations
Dual channel confocal laser scanning microscopy of lucifer yellow-microinjected human brain cells combined with Texas red immunofluorescence
1994 • 15 citations