Dynamin Is a Minibrain Kinase/Dual Specificity Yak1-related Kinase 1A Substrate

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Nuclear targeting sequences — a consensus?

1991 • 1,908 citations

The DNA sequence of human chromosome 21

2000 • 1,406 citations

Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

1995 • 816 citations

Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

1995 • 760 citations

Dynamin and Its Role in Membrane Fission

2000 • 689 citations

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

1998 • 665 citations

The GTPase dynamin binds to and is activated by a subset of SH3 domains

1993 • 557 citations

Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

1998 • 542 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

Disruption of neurotransmission in Drosophila mushroom body blocks retrieval but not acquisition of memory

2001 • 468 citations

The Role of Drosophila Mushroom Body Signaling in Olfactory Memory

2001 • 456 citations

GTPase activity of dynamin and resulting conformation change are essential for endocytosis

2001 • 451 citations

A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

1996 • 408 citations

Dynamin and its partners: a progress report

1998 • 403 citations

The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain

1997 • 383 citations

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome

2001 • 382 citations

minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila

1995 • 374 citations

Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis

1999 • 364 citations

The dynamin family of mechanoenzymes: pinching in new places

2000 • 345 citations

Endophilin/SH3p4 Is Required for the Transition from Early to Late Stages in Clathrin-Mediated Synaptic Vesicle Endocytosis

1999 • 328 citations

The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bɛ at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

2001 • 319 citations

Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome

1997 • 318 citations

Role of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes

1998 • 310 citations

Fission and Uncoating of Synaptic Clathrin-Coated Vesicles Are Perturbed by Disruption of Interactions with the SH3 Domain of Endophilin

2000 • 297 citations

Sequence Characteristics, Subcellular Localization, and Substrate Specificity of DYRK-related Kinases, a Novel Family of Dual Specificity Protein Kinases

1998 • 274 citations

Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals

1993 • 272 citations

The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site

2001 • 266 citations

The SH3 Domain of Amphiphysin Binds the Proline-rich Domain of Dynamin at a Single Site That Defines a New SH3 Binding Consensus Sequence

1997 • 256 citations

Dyrk, a Dual Specificity Protein Kinase with Unique Structural Features Whose Activity Is Dependent on Tyrosine Residues between Subdomains VII and VIII

1996 • 248 citations

The amphiphysin family of proteins and their role in endocytosis at the synapse

1998 • 246 citations

Specificity Determinants of Substrate Recognition by the Protein Kinase DYRK1A

2000 • 231 citations

Structural and Functional Characteristics of Dyrk, a Novel Subfamily of Protein Kinases with Dual Specificity

1998 • 219 citations

A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region

1996 • 212 citations

Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase.

1989 • 199 citations

Differential expression and regulation of multiple dynamins.

1994 • 172 citations

Isolation of Human and Murine Homologues of theDrosophilaMinibrain Gene: Human Homologue Maps to 21q22.2 in the Down Syndrome “Critical Region”

1996 • 171 citations

Identification of the Major Synaptojanin-binding Proteins in Brain

1997 • 169 citations

The SH3 Domains of Endophilin and Amphiphysin Bind to the Proline-rich Region of Synaptojanin 1 at Distinct Sites That Display an Unconventional Binding Specificity

1999 • 128 citations

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

1997 • 125 citations

Activation of Androgen Receptor Function by a Novel Nuclear Protein Kinase

1998 • 118 citations

Cloning of a Human Homolog of theDrosophila Minibrain/Rat Dyrk Gene from “the Down Syndrome Critical Region” of Chromosome 21

1996 • 118 citations

Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter

1990 • 116 citations

Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.

2000 • 101 citations

Molecular interaction of dihydropyridine receptors with type-1 ryanodine receptors in rat brain

2001 • 91 citations

Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division

2001 • 89 citations

A Novel SH3-Containing Human Gene Family Preferentially Expressed in the Central Nervous System

1997 • 89 citations

Insulin Stimulates Sequestration of β-Adrenergic Receptors and Enhanced Association of β-Adrenergic Receptors with Grb2 via Tyrosine 350

1998 • 87 citations

Dynamin GTPase is stimulated by crosslinking through the C-terminal proline-rich domain.

1995 • 85 citations

Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.

1997 • 75 citations

A complex of GRB2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment.

1994 • 71 citations

[35] Assessing activities of blotted protein kinases

1991 • 54 citations

Down syndrome and mouse models

1998 • 54 citations

Dephosphorylation of Synaptosomal Proteins P96 and P139 Is Regulated by Both Depolarization and Calcium, but Not by a Rise in Cytosolic Calcium Alone

1987 • 48 citations

Expression of the Mnb (dyrk) Protein in Adult and Embryonic Mouse Tissues

1998 • 46 citations

Mutagenesis of the H-ras p21 at glycine-60 residue disrupts GTP-induced conformational change

1995 • 45 citations

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin

2001 • 44 citations

Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34

2000 • 41 citations

The MurineDyrkProtein Maps to Chromosome 16, Localizes to the Nucleus, and Can Form Multimers

1997 • 38 citations

High Affinity Binding of Brain Myosin-Va to F-actin Induced by Calcium in the Presence of ATP

2001 • 30 citations

Primary structure of human amphiphysin, the dominant autoantigen of paraneoplastic Stiff—Man syndrome, and mapping of its gene (AMPH) to chromosome 7p13–p14

1995 • 26 citations

Dynamin Associates with Src-Homology Collagen (SHC) and Becomes Tyrosine Phosphorylated in Response to Insulin

1998 • 25 citations

Signaling Through Grb2/Ash-Control of the Ras Pathway and Cytoskeleton

1998 • 22 citations

A solid-phase assay for the phosphorylation of proteins blotted on nitrocellulose membrane filters

1986 • 22 citations

Localisation of a human homologue of the Drosophila mnb and rat Dyrk genes to chromosome 21q22.2

1997 • 21 citations

MurineMyak, a member of a family of yeastYAK1-related genes, is highly expressed in hormonally modulated epithelia in the reproductive system and in the embryonic central nervous system

2000 • 6 citations

Minibrain (MNBH) is a single copy gene mapping to human chromosome 21q22.2

1997 • 4 citations