Reduction of nitroimidazole derivatives by hydrogenosomal extracts of Trichomonas vaginalis

Energy conservation in chemotrophic anaerobic bacteria

1977 • 3,509 citations

The Establishment of Various Trichomonads of Animals and Man in Axenic Cultures

1957 • 970 citations

Hydrogenosome, a Cytoplasmic Organelle of the Anaerobic Flagellate Tritrichomonas foetus, and Its Role in Pyruvate Metabolism

1973 • 415 citations

Antitrichomonad Action, Mutagenicity, and Reduction of Metronidazole and Other Nitroimidazoles

1976 • 245 citations

Structure-activity Relationships in the Development of Hypoxic Cell Radiosensitizers

1979 • 231 citations

Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.

1980 • 161 citations

One-electron reduction potentials of substituted nitroimidazoles measured by pulse radiolysis

1976 • 145 citations

Correlation between rate constant for reduction and redox potential as a basis for systematic investigation of reaction mechanisms of electron transfer proteins.

1983 • 127 citations

The Selective Toxicity of Antimicrobial Nitroheterocyclic Drugs

1973 • 127 citations

Screening for the mutagenicity of nitro-group containing hypoxic cell radiosensitizers using Salmonella typhimurium strains TA 100 and TA 98

1978 • 91 citations

Hydrogenosomes in Trichomonas vaginalis

1975 • 80 citations

Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes.

1984 • 79 citations

Hydrogenosomal ferredoxin of the anaerobic protozoon, Tritrichomonas foetus.

1983 • 78 citations

Mechanism of antimicrobial action of metronidazole

1979 • 77 citations

A simple hydrogenase-linked assay for ferredoxin and flavodoxin

1979 • 76 citations

Anaerobic reduction of nitroimidazoles by reduced flavin mononucleotide and by xanthine oxidase

1980 • 72 citations

Nitroimidazoles as anaerobic electron acceptors for xanthine oxidase

1982 • 65 citations

On the Reduction of Aliphatic and Aromatic Nitro Compounds byClostridia,the Role of Ferredoxin and its Stabilization

1983 • 64 citations

Metabolic differences between metronidazole resistant and susceptible strains of Tritrichomonas foetus

1984 • 63 citations

Isolation and Properties of Metronidazole-Resistant Mutants of Bacteroides fragilis

1979 • 63 citations

Effect of metronidazole on hydrogen production by Clostridium acetobutylicum

1972 • 62 citations

Studies on the action of nitroimidazole drugs

1983 • 59 citations

Relationship between metronidazole metabolism and bactericidal activity

1980 • 56 citations

Isolation and characterization of Trichomonas vaginalis ferredoxin

1984 • 53 citations

Action of clinically utilized 5-nitroimidazoles on microorganisms.

1981 • 51 citations

Radiosensitization, Mutagenicity, and Toxicity of Escherichia coli by Several Nitrofurans and Nitroimidazoles

1978 • 36 citations

Activity-electroreduction relationship of antimicrobial metronidazole analogs

1978 • 34 citations

The activity of nitro-compounds against Bacteroides fragilis is related to their electron affinity

1981 • 30 citations

A new, fast, and sensitive assay for NADH-ferredoxin oxidoreductase detection in clostridia

1981 • 30 citations

Isolation and Properties of Metronidazole-resistant Mutants of Clostridium Perfringens

1982 • 27 citations

Mechanism of the reduction of organic nitro compounds by chloroplasts

1965 • 26 citations

Quantitative relationship between structure and mutagenic activity in a series of 5-nitroimidazoles

1983 • 21 citations

Reaction of c-Type Cytochromes with the Iron Hexacyanides

1981 • 19 citations

Reduction of nitroimidazoles in model chemical and biological systems

1982 • 17 citations

Nitroimidazoles with antibacterial activity against Neisseria gonorrhoeae

1977 • 13 citations