Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages.

1992 • 3,279 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

2001 • 1,264 citations

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

1998 • 1,226 citations

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

2001 • 1,094 citations

CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism

2001 • 1,070 citations

The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

2001 • 990 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 975 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 856 citations

Expression cloning of SR-BI, a CD36-related class B scavenger receptor.

1994 • 818 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism

1999 • 758 citations

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

1996 • 726 citations

High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase

2001 • 712 citations

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

1996 • 649 citations

The scavenger cell pathway for lipoprotein degradation: Specificity of the binding site that mediates the uptake of negatively‐charged LDL by macrophages

1980 • 543 citations

Charting the Fate of the “Good Cholesterol”: Identification and Characterization of the High-Density Lipoprotein Receptor SR-BI

1999 • 515 citations

Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology

1999 • 496 citations

Glycation Products and the Pathogenesis of Diabetic Complications

1992 • 493 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.

1991 • 415 citations

A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes.

1989 • 377 citations

CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

2002 • 371 citations

Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.

1990 • 360 citations

Identification of Microglial Signal Transduction Pathways Mediating a Neurotoxic Response to Amyloidogenic Fragments of β-Amyloid and Prion Proteins

1999 • 353 citations

Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes

1997 • 323 citations

The role of AGEs in aging: causation or correlation

2001 • 321 citations

Scavenger receptor family proteins: roles for atherosclerosis, host defence and disorders of the central nervous system

1998 • 268 citations

Regulated expression of CD36 during monocyte-to-macrophage differentiation: potential role of CD36 in foam cell formation

1996 • 260 citations

Nonopsonic monocyte/macrophage phagocytosis of Plasmodium falciparum–parasitized erythrocytes: a role for CD36 in malarial clearance

2000 • 256 citations

beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes.

1998 • 253 citations

CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products

2001 • 242 citations

CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium

1996 • 220 citations

β-Amyloid Fibrils Activate Parallel Mitogen-Activated Protein Kinase Pathways in Microglia and THP1 Monocytes

1998 • 201 citations

Lipoproteins in the Central Nervous System

2000 • 200 citations

Aβ-Induced Inflammatory Processes in Microglia Cells of APP23 Transgenic Mice

2001 • 199 citations

Oxidized LDL–Induced NF-κB Activation and Subsequent Expression of Proinflammatory Genes Are Defective in Monocyte-Derived Macrophages From CD36-Deficient Patients

2000 • 197 citations

Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors.

1994 • 182 citations

Scavenger Receptor Class B Type I-mediated Reverse Cholesterol Transport Is Inhibited by Advanced Glycation End Products

2001 • 173 citations

Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis.

1995 • 168 citations

Expression of Human Scavenger Receptor Class B Type I in Cultured Human Monocyte-Derived Macrophages and Atherosclerotic Lesions

1999 • 167 citations

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.

1996 • 152 citations

SRB1, a Class B Scavenger Receptor, Recognizes both Negatively Charged Liposomes and Apoptotic Cells

1996 • 144 citations

Activation of monocytes and platelets by monoclonal antibodies or malaria-infected erythrocytes binding to the CD36 surface receptor in vitro.

1989 • 143 citations

Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL‐associated vitamin E

2001 • 142 citations

Phagocytosis and development: back to the future

1999 • 125 citations

Scavenger receptors: diverse activities and promiscuous binding of polyanionic ligands

1998 • 124 citations

Upregulation of the macrophage scavenger receptor in response to different forms of injury in the CNS

1994 • 120 citations

Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar β-amyloid

2001 • 120 citations

Identification on Human CD36 of a Domain (155-183) Implicated in Binding Oxidized Low-Density Lipoproteins (Ox-LDL)

1996 • 116 citations

Expression of Scavenger Receptor Class B, Type I, by Astrocytes and Vascular Smooth Muscle Cells in Normal Adult Mouse and Human Brain and in Alzheimer’s Disease Brain

2001 • 114 citations

Platelet glycoprotein IV (CD36) deficiency is associated with the absence (type I) or the presence (type II) of glycoprotein IV on monocytes

1994 • 114 citations

Oxidized LDL Increases and Interferon-γ Decreases Expression of CD36 in Human Monocyte–Derived Macrophages

1998 • 105 citations

Regulation of β-amyloid stimulated proinflammatory responses by peroxisome proliferator-activated receptor α

2001 • 100 citations

Identification of a Domain (155–183) on CD36 Implicated in the Phagocytosis of Apoptotic Neutrophils

1996 • 96 citations

Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells

2000 • 93 citations

Complementary Roles for Scavenger Receptor A and CD36 of Human Monocyte–derived Macrophages in Adhesion to Surfaces Coated with Oxidized Low-Density Lipoproteins and in Secretion of H2O2

1998 • 86 citations

Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice

1999 • 85 citations

Human Retinal Pigment Epithelial Cells Express Scavenger Receptors BI and BII

2002 • 82 citations

The inflammatory response in the CNS

1992 • 72 citations

Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase

2000 • 70 citations

Elimination of the Class A Scavenger Receptor Does Not Affect Amyloid Plaque Formation or Neurodegeneration in Transgenic Mice Expressing Human Amyloid Protein Precursors

1999 • 66 citations

Lipopolysaccharide Inhibits the Expression of the Scavenger Receptor Cla-1 in Human Monocytes and Macrophages

1999 • 62 citations

CD36 Induction on Human Monocytes upon Adhesion to Tumor Necrosis Factor-activated Endothelial Cells

1995 • 62 citations

New Scavenger Receptor-Like Receptors for the Binding of Lipopolysaccharide to Liver Endothelial and Kupffer Cells

1998 • 61 citations

Scavenger receptor class B type I expression and elemental analysis in cerebellum and parietal cortex regions of the Alzheimer's disease brain

2002 • 60 citations

Series Introduction: Multiligand receptors and human disease

2001 • 59 citations

The Multiple Roles of Macrophage Scavenger Receptors (MSR) in vivo : Resistance to Atherosclerosis and Susceptibility to Infection in MSR Knockout Mice

1997 • 57 citations

Scavenger receptor-like receptors for the binding of lipopolysaccharide and lipoteichoic acid to liver endothelial and Kupffer cells

2001 • 55 citations

Oxidized lipoproteins increase reactive oxygen species formation in microglia and astrocyte cell lines

1999 • 54 citations

Cerebrospinal fluid lipoproteins are more vulnerable to oxidation in Alzheimer's disease and are neurotoxic when oxidized ex vivo

1999 • 54 citations

The Role of the Mouse Macrophage Scavenger Receptor in Myelin Phagocytosis

1997 • 54 citations

Series Introduction: Multiligand receptors and human disease

2001 • 52 citations

Immunohistochemical Evidence for a Macrophage Scavenger Receptor in Mato Cells and Reactive Microglia of Ischemia and Alzheimer's Disease

1998 • 50 citations

Human CD36 deficiency is associated with elevation in low-density lipoprotein-cholesterol

2000 • 48 citations

Identification of an immunodominant functional domain on human CD36 antigen using human-mouse chimaeric proteins and homologue-replacement mutagenesis

1995 • 45 citations

Uptake of fibrillar β-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice

2001 • 43 citations

Absent myocardial iodine-123-BMIPP uptake and platelet/monocyte CD36 deficiency.

1998 • 41 citations

Expression of receptors for native and chemically modified low‐density lipoproteins in brain microvessels

1997 • 40 citations

Apolipoprotein E, Smooth Muscle Cells and the Pathogenesis of Cerebral Amyloid Angiopathy: the Potential Role of Impaired Cerebrovascular Aβ Clearance

2000 • 36 citations

CD11b/CD18 Mediates Production of Reactive Oxygen Species by Mouse and Human Macrophages Adherent to Matrixes Containing Oxidized LDL

2001 • 35 citations

Modulation of microglia phenotype.

1994 • 34 citations

Amyloid β protein activates PKC-δ and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia

2001 • 34 citations

Scavenger receptor mRNAs in rat brain microglia are induced by kainic acid lesioning and by cytokines

1997 • 34 citations

High‐Density Lipoprotein Aggregated by Oxidation Induces Degeneration of Neuronal Cells

1997 • 32 citations

Oxidized High-Density Lipoprotein Induces Neuron Death

2000 • 28 citations

Membrane unpacking and the rapid disposal of apoptotic cells

1995 • 26 citations

Activation of the M-CSF gene in mouse macrophages immortalized by retroviruses carrying a v-myc oncogene.

1991 • 21 citations

Onion-Bulb Formation after a Single Compression Injury in the Macrophage Scavenger Receptor Knockout Mice

2000 • 15 citations