Smooth Muscle Differentiation Marker Gene Expression Is Regulated by RhoA-mediated Actin Polymerization

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of differentiation of vascular smooth muscle cells

1995 • 1,681 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

2000 • 1,219 citations

Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling

1998 • 719 citations

Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics

1999 • 656 citations

Multiple protein-binding sites in the 5'-flanking region regulate c-fos expression.

1986 • 516 citations

Effects of Jasplakinolide on the Kinetics of Actin Polymerization

2000 • 504 citations

The serum response element

1992 • 458 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

The ets gene family

1992 • 308 citations

GATA-4 and Nkx-2.5 Coactivate Nkx-2 DNA Binding Targets: Role for Regulating Early Cardiac Gene Expression

1998 • 303 citations

Recruitment of the Tinman Homolog Nkx-2.5 by Serum Response Factor Activates Cardiac α-Actin Gene Transcription

1996 • 277 citations

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [published erratum appears in J Cell Biol 1994 Mar;124(5):865]

1994 • 271 citations

Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 • 260 citations

Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET).

1995 • 255 citations

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation

1998 • 243 citations

Nuclear export of actin: a novel mechanism regulating the subcellular localization of a major cytoskeletal protein

1998 • 239 citations

Regulation of Smooth Muscle α-Actin Expression In Vivo Is Dependent on CArG Elements Within the 5′ and First Intron Promoter Regions

1999 • 237 citations

Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation

1998 • 230 citations

Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies.

1991 • 224 citations

Net, a new ets transcription factor that is activated by Ras.

1994 • 216 citations

A Serum Response Factor-Dependent Transcriptional Regulatory Program Identifies Distinct Smooth Muscle Cell Sublineages

1997 • 211 citations

Transformation mediated by RhoA requires activity of ROCK kinases

1999 • 209 citations

Mechanotransduction of Rat Aortic Vascular Smooth Muscle Cells Requires RhoA and Intact Actin Filaments

1999 • 203 citations

Involvement of Rho-Kinase in Angiotensin II–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells

2000 • 177 citations

Cytoskeletal Rearrangements and Transcriptional Activation of c-fos Serum Response Element by Rho-kinase

1997 • 176 citations

The Smooth Muscle α-Actin Gene Promoter Is Differentially Regulated in Smooth Muscle versus Non-smooth Muscle Cells

1995 • 167 citations

Evidence for Serum Response Factor-Mediated Regulatory Networks GoverningSM22αTranscription in Smooth, Skeletal, and Cardiac Muscle Cells

1997 • 166 citations

Cytoskeletal features of normal andatheromatous human arterial smooth muscle cells

1986 • 163 citations

RhoA Signaling via Serum Response Factor Plays an Obligatory Role in Myogenic Differentiation

1998 • 163 citations

The Rho Family G Proteins Play a Critical Role in Muscle Differentiation

1998 • 152 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Organization and Myogenic Restricted Expression of the Murine Serum Response Factor Gene

1997 • 145 citations

Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase

1996 • 137 citations

Requirement for Rho in Integrin Signalling

1997 • 127 citations

Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation.

1992 • 123 citations

Intranuclear injection of anti-actin antibodies into Xenopus oocytes blocks chromosome condensation

1979 • 122 citations

Activation of the cardiac α-actin promoter depends upon serum response factor,Tinman homologue, Nkx-2.5, and intact serum response elements

1996 • 120 citations

SRF and TEF-1 control of chicken skeletal alpha-actin gene during slow-muscle hypertrophy

1996 • 120 citations

Serum Response Factor-dependent Regulation of the Smooth Muscle Calponin Gene

2000 • 117 citations

Platelet-derived growth factor regulates actin isoform expression and growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cells

1990 • 114 citations

Smooth Muscle α-Actin CArG Elements Coordinate Formation of a Smooth Muscle Cell–Selective, Serum Response Factor–Containing Activation Complex

2000 • 111 citations

Expression of the Smooth Muscle Myosin Heavy Chain Gene Is Regulated by a Negative-acting GC-rich Element Located between Two Positive-acting Serum Response Factor-binding Elements

1997 • 105 citations

Involvement of Multiple cis Elements in Basal- and α-Adrenergic Agonist–Inducible Atrial Natriuretic Factor Transcription

1995 • 104 citations

Physical Interaction between the Mitogen-responsive Serum Response Factor and Myogenic Basic-Helix-Loop-Helix Proteins

1996 • 100 citations

Dominant Negative Murine Serum Response Factor: Alternative Splicing within the Activation Domain Inhibits Transactivation of Serum Response Factor Binding Targets

1999 • 94 citations

A Skeletal Muscle-Specific Enhancer Regulated by Factors Binding to E and CArG Boxes Is Present in the Promoter of the Mouse Myosin Light-Chain 1A Gene

1995 • 91 citations

Myocyte-Specific Enhancer Factor 2 and Thyroid Hormone Receptor Associate and Synergistically Activate the α-Cardiac Myosin Heavy-Chain Gene

1997 • 90 citations

Expression of the Serum Response Factor Gene Is Regulated by Serum Response Factor Binding Sites

1996 • 89 citations

Competition Between Negative Acting YY1versusPositive Acting Serum Response Factor and Tinman Homologue Nkx-2.5 Regulates Cardiac α-Actin Promoter Activity

1997 • 73 citations

Four isoforms of serum response factor that increase or inhibit smooth-muscle-specific promoter activity

2000 • 60 citations

Muscle-specific gene expression. A comparison of cardiac and skeletal muscle transcription strategies.

1993 • 54 citations

Telokin expression in A10 smooth muscle cells requires serum response factor

1997 • 53 citations

Transcriptional Regulation of the Chicken Caldesmon Gene

1995 • 53 citations

Functional Involvement of Serum Response Factor in the Transcriptional Regulation of Caldesmon Gene

1998 • 18 citations

Role of Rho GTPase in the Endothelin-1-Induced Nuclear Signaling

1997 • 18 citations