Mechanisms of Human Papillomavirus E2-Mediated Repression of Viral Oncogene Expression and Cervical Cancer Cell Growth Inhibition

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

1985 • 1,481 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1998 • 1,206 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.

1991 • 872 citations

Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex

1994 • 766 citations

Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines

1987 • 760 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

Repression and activation by multiprotein complexes that alter chromatin structure.

1996 • 444 citations

Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product

1985 • 402 citations

Targeting the E1 Replication Protein to the Papillomavirus Origin of Replication by Complex Formation with the E2 Transactivator

1990 • 396 citations

Bovine papillomavirus E2 trans-activating gene product binds to specific sites in papillomavirus DNA

1987 • 330 citations

Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis.

1987 • 327 citations

Disruption of either the E1 or the E2 regulatory gene of human papillomavirus type 16 increases viral immortalization capacity.

1992 • 315 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

Activation of BPV-1 replication in vitro by the transcription factor E2

1991 • 284 citations

Charles S. Mott prize papillomaviruses in human cancer

1987 • 283 citations

The papillomavirus E2 regulatory proteins.

1991 • 276 citations

Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters

1990 • 265 citations

Papillomaviruses in Human Cancers

2003 • 240 citations

Suppression of cellular proliferation by the papillomavirus E2 protein

1995 • 220 citations

Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis

1997 • 219 citations

The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes

1989 • 218 citations

Human Papillomaviruses and cervical Cancer

1997 • 191 citations

The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID

1994 • 187 citations

Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein

1997 • 187 citations

Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.

1995 • 184 citations

Transient replication of human papillomavirus DNAs

1992 • 177 citations

Integration of human papillomavirus type 16 DNA sequences: a possible early event in the progression of genital tumors

1987 • 163 citations

Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene

1993 • 159 citations

Repression of the Integrated Papillomavirus E6/E7 Promoter Is Required for Growth Suppression of Cervical Cancer Cells

2000 • 156 citations

The functional BPV-1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex.

1991 • 154 citations

Physical Status and Expression of HPV Genes in Cervical Cancers

1997 • 145 citations

Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements

1994 • 141 citations

Integration and Transcription of Human Papillomavirus Type 16 and 18 Sequences in Cell Lines Derived from Cervical Carcinomas

1987 • 134 citations

Functional analysis of E2-mediated repression of the HPV18 P105 promoter.

1991 • 132 citations

Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions

1996 • 123 citations

Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes

1997 • 120 citations

During negative regulation of the human papillomavirus-16E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element

1992 • 115 citations

Transactivation-Competent Bovine Papillomavirus E2 Protein Is Specifically Required for Efficient Repression of Human Papillomavirus Oncogene Expression and for Acute Growth Inhibition of Cervical Carcinoma Cell Lines

1998 • 112 citations

The Chromatin Structure of the Long Control Region of Human Papillomavirus Type 16 Represses Viral Oncoprotein Expression

1999 • 111 citations

Interplay between chromatin structure and transcription

1995 • 110 citations

Control of human papillomavirus type 11 origin of replication by the E2 family of transcription regulatory proteins

1992 • 99 citations

Interplay of viral and cellular proteins along the long control region of human papillomavirus type 18

1988 • 98 citations

Transactivation by the E2 Protein of Oncogenic Human Papillomavirus Type 31 Is Not Essential for Early and Late Viral Functions

1998 • 93 citations

Bovine papillomavirus type 1 E2 transcriptional regulators directly bind two cellular transcription factors, TFIID and TFIIB

1995 • 91 citations

Activation of the endogenous p53 growth inhibitory pathway in HeLa cervical carcinoma cells by expression of the bovine papillomavirus E2 gene.

1996 • 90 citations

Mapping and characterization of the interaction domains of human papillomavirus type 16 E1 and E2 proteins

1997 • 80 citations

The E2 transcriptional repressor can compensate for Sp1 activation of the human papillomavirus type 18 early promoter

1994 • 78 citations

The bovine papillomavirus 1 E2 protein contains two activation domains: one that interacts with TBP and another that functions after TBP binding.

1995 • 73 citations

Calcium Phosphate Transfection

1997 • 68 citations

Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance.

1990 • 66 citations

Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication

1996 • 66 citations

Papillomaviruses in Human Cancer

1997 • 58 citations

Transcription Factor E2 Regulates BPV-1 DNA Replication In Vitro by Direct Protein-Protein Interaction

1991 • 53 citations

Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins

1997 • 46 citations

Transcriptional activation function is not required for stimulation of DNA replication by bovine papillomavirus type 1 E2

1996 • 42 citations

A Fifteen-Amino-Acid Peptide Inhibits Human Papillomavirus E1-E2 Interaction and Human Papillomavirus DNA Replication In Vitro

1998 • 38 citations

Both viral E2 protein and the cellular factor PEBP2 regulate transcription via E2 consensus sites within the bovine papillomavirus type 4 long control region

1995 • 27 citations

Activation domain-mediated enhancement of activator binding to chromatin in mammalian cells.

1996 • 25 citations

Early promoters of genital and cutaneous human papillomaviruses are differentially regulated by the bovine papillomavirus type 1 E2 gene product

1992 • 22 citations

Cooperative Activation of Transcription by Bovine Papillomavirus Type 1 E2 Can Occur over a Large Distance

1990 • 12 citations

Human Papillomaviruses and Cancer: A Retrospective

1997 • 4 citations