Angiotensin type 1 receptor antagonism reverses abnormal coronary vasomotion in atherosclerosis

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

1995 • 1,632 citations

Angiotensin-Converting Enzyme Inhibition With Quinapril Improves Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 1,065 citations

Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity.

1992 • 1,021 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Endothelium‐dependent hyperpolarization of canine coronary smooth muscle

1988 • 785 citations

Control of coronary vascular tone by nitric oxide.

1990 • 713 citations

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.

1997 • 603 citations

Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test.

1988 • 564 citations

The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.

1997 • 481 citations

Increased Accumulation of Tissue ACE in Human Atherosclerotic Coronary Artery Disease

1996 • 431 citations

Atherosclerosis impairs flow-mediated dilation of coronary arteries in humans.

1989 • 421 citations

Endothelium-dependent, flow-induced dilation of isolated coronary arterioles

1990 • 420 citations

Vasoconstriction of stenotic coronary arteries during dynamic exercise in patients with classic angina pectoris: reversibility by nitroglycerin.

1986 • 371 citations

Atherosclerosis influences the vasomotor response of epicardial coronary arteries to exercise.

1989 • 368 citations

Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium

1989 • 346 citations

Role of Bradykinin in Mediating Vascular Effects of Angiotensin-Converting Enzyme Inhibitors in Humans

1997 • 332 citations

Angiotensin II Increases Tissue Endothelin and Induces Vascular Hypertrophy

1997 • 329 citations

Contribution of Nitric Oxide to Metabolic Coronary Vasodilation in the Human Heart

1995 • 314 citations

Coronary Kinin Generation Mediates Nitric Oxide Release After Angiotensin Receptor Stimulation

1995 • 259 citations

Coronary Microcirculation in Health and Disease

1997 • 217 citations

Acute and Chronic Angiotensin-1 Receptor Antagonism Reverses Endothelial Dysfunction in Atherosclerosis

2000 • 196 citations

Paradoxical narrowing of atherosclerotic coronary arteries induced by increases in heart rate.

1990 • 190 citations

Infarct size reduction by AT1-receptor blockade through a signal cascade of AT2-receptor activation, bradykinin and prostaglandins in pigs

1998 • 178 citations

Evidence That Macrophages in Atherosclerotic Lesions Contain Angiotensin II

1998 • 142 citations

The Angiotensin-II Receptor Antagonist, Losartan, Inhibits LDL Lipid Peroxidation and Atherosclerosis in Apolipoprotein E-Deficient Mice

1997 • 138 citations

The Renin-Angiotensin System and Vascular Hypertrophy

1996 • 124 citations

Angiotensin II Increases Monocyte Binding to Endothelial Cells

1996 • 115 citations

Endothelial dysfunction in spontaneously hypertensive rats

1997 • 106 citations

Effect of selective angiotensin II receptor antagonism and angiotensin converting enzyme inhibition on the coronary vasculature in vivo. Intravascular two-dimensional and Doppler ultrasound studies.

1993 • 98 citations

Angiotensin II receptors in endothelial cells

1997 • 65 citations

Coronary microcirculation: autoregulation and metabolic control

1995 • 62 citations

Abnormal flow-mediated epicardial vasomotion in human coronary arteries is improved by angiotensin-converting enzyme inhibition

1999 • 62 citations

Effects of losartan on vasoconstrictor responses to angiotensin II in the forearm vascular bed of healthy volunteers

1996 • 35 citations

Effect of enalaprilat on nitric oxide activity in coronary artery disease

1999 • 33 citations

Impact of Coronary Risk Factors on Contribution of Nitric Oxide and Adenosine to Metabolic Coronary Vasodilation in Humans

1998 • 32 citations

Inhibition of Nitric Oxide Synthesis During the Cold Pressor Test in Patients With Coronary Artery Disease

1997 • 28 citations

Endogenous angiotensin II contributes to basal peripheral vascular tone in sodium deplete but not sodium replete man

1997 • 28 citations

Modulation of Sympathetic Coronary Vasoconstriction by Cardiac Renin-Angiotensin System in Human Coronary Heart Disease

2000 • 27 citations

Effects of losartan on vasoconstrictor responses to angiotensin II in the forearm vascular bed of healthy volunteers

1996 • 12 citations