Differentiation of Genetic Versus Epigenetic Mechanisms of Toxicity and Its Application to Risk Assessment

DNA Methylation and Gene Function

1980 • 2,069 citations

Rate of depurination of native deoxyribonucleic acid

1972 • 1,488 citations

Chemical Mutagens. Principles and Methods for Their Detection.

1974 • 1,473 citations

Normal genetically mosaic mice produced from malignant teratocarcinoma cells.

1975 • 1,175 citations

Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli.

1976 • 942 citations

Complementary base pairing and the origin of substitution mutations

1976 • 835 citations

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

1974 • 725 citations

Detection of chemical carcinogens by unscheduled DNA synthesis in rat liver primary cell cultures.

1977 • 470 citations

Fate of teratocarcinoma cells injected into early mouse embryos

1975 • 461 citations

A General Theory of Carcinogenesis

1973 • 456 citations

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

1979 • 412 citations

Origin of Malignant Tumors.

1929 • 325 citations

Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents

1977 • 304 citations

N-nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis.

1979 • 276 citations

Spontaneous Mutation: Comparative Rates of Spontaneous Mutation

1969 • 268 citations

DNA excision-repair processes in human cells can eliminate the cytotoxic and mutagenic consequences of ultraviolet irradiation

1979 • 245 citations

Mutagenicity of carcinogenic methylating agents is associated with a specific DNA modification

1980 • 234 citations

Mutagenicity in vitro and potential carcinogenicity of chlorinated ethylenes as a function of metabolic oxirane formation

1975 • 232 citations

Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues

1979 • 221 citations

Heat-induced depyrimidination of deoxyribonucleic acid in neutral solution

1973 • 213 citations

A new theory of carcinogenesis

1979 • 201 citations

Mutagenic and carcinogenic N-nitroso compounds: Possible environmental hazards

1976 • 201 citations

DNA repair synthesis of cultured human cells as a rapid bioassay for chemical carcinogens

1975 • 176 citations

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

1979 • 165 citations

Transplantation of Pluripotential Nuclei from Triploid Frog Tumors

1969 • 160 citations

On the fidelity of DNA replication. Effect of divalent metal ion activators and deoxyrionucleoside triphosphate pools on in vitro mutagenesis.

1979 • 151 citations

On the Fidelity of DNA Replication

1979 • 144 citations

On the distributions of frequencies of mutation to genes determining harmful traits in man

1967 • 124 citations

1,4-Dioxane. I. Results of a 2-year ingestion study in rats

1974 • 121 citations

Induction of an error-prone mode of DNA repair in UV-irradiated monkey kidney cells

1980 • 120 citations

The pharmacokinetics and macromolecular interactions of perchloroethylene in mice and rats as related to oncogenicity

1980 • 120 citations

Results of a two year chronic toxicity study with hexachlorobutadiene in rats

1977 • 115 citations

Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts

1977 • 109 citations

“Private” Genetic Variants and the Frequency of Mutation Among South American Indians

1973 • 107 citations

Subcutaneous sarcoma as an index of carcinogenic potency

1966 • 99 citations

Vitamin C is positive in the DNA synthesis inhibition and sister-chromatid exchange tests

1979 • 97 citations

The Detection of Chemical Mutagens/Carcinogens by DNA Repair and Mutagenesis in Liver Cultures

1980 • 96 citations

Error-free excision of the cytotoxic,mutagenic N2-deoxyguanosine DNA adduct formed in human fibroblasts by (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

1980 • 87 citations

Modification of Mutagenic Activity

1980 • 76 citations

Effects of depurination on the fidelity of DNA synthesis

1979 • 76 citations

Studies on the Carcinogenic Activity of Protein-Denaturing Agents: Hepatocarcinogenicity of Dioxane<xref ref-type="fn" rid="FN2">2</xref>

1965 • 76 citations

Induction of Carcinomas in the Nasal Cavity of Rats by Dioxane

1970 • 75 citations

Differentiation of the mechanisms of oncogenicity of 1,4-dioxane and 1,3-hexachlorobutadiene in the rat

1981 • 75 citations

On the fidelity of DNA replication. Metal activation of Escherichia coli DNA polymerase I.

1979 • 65 citations

Metabolic activation of chlorinated ethylenes: dependence of mutagenic effect on electrophilic reactivity of the metabolically formed epoxides

1977 • 63 citations

DNA AS A TARGET OF ALKYLATING CARCINOGENS

1980 • 61 citations

Effects of vinylidene chloride on DNA synthesis and DNA repair in the rat and mouse: A comparative study with dimethylnitrosamine

1980 • 58 citations

A test for mutation theory of cancer: Carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide

1977 • 56 citations

Aberrant methylation of liver DNA in rats during hepatotoxicity

1981 • 56 citations

DNA REPAIR AND MUTAGENESIS IN MAMMALIAN CELLS*^,†

1978 • 55 citations

1,4-Dioxane. II. Results of a 2-year inhalation study in rats

1974 • 51 citations

Inhibition of Phorbol Ester-Induced Tumor Promotion in Mice by Vitamin A Analog and Anti-inflammatory Steroid<xref ref-type="fn" rid="FN2">2</xref>

1979 • 51 citations

Established Principles and Unresolved Problems in Carcinogenesis

1978 • 50 citations

Mutagenic activity of chloroethylenes analysed by screening system tests

1977 • 50 citations

Mutagenicity of dimethylnitrosamine to mammalian cells as determined by the use of mouse liver microsomes

1975 • 49 citations

Primary Carcinoma of the Liver

1975 • 48 citations

Enhancement of mutagenesis during cell replication of cultured liver epithelial cells

1978 • 37 citations

RELATIONSHIP BETWEEN MUTAGENESIS AND CARCINOGENESIS*

1978 • 35 citations

Facilitation by pyrimidine deoxyribonucleosides and hypoxanthine of mutagenic and cytotoxic effects of monofunctional alkylating agents in Chinese hamster cells

1979 • 33 citations

Bacterial mutagenesis: Review of new insights

1980 • 32 citations

Chromosome aberrations in mammalian cells exposed to vitamin C and multiple vitamin pills

1980 • 24 citations

HOW EFFICIENT IS IMMUNOLOGICAL SURVEILLANCE AGAINST CANCER AND WHY DOES IT FAIL ?

1974 • 23 citations

Steroids and carcinogenesis

1975 • 22 citations

Comparison and Evaluation of Some Experimental Designs for Use in Carcinogen Screening<xref ref-type="fn" rid="FN1">2</xref>

1979 • 16 citations

Effect of Partial Hepatectomy on Tumor Incidence and Metabolism of Mice Fed Thioacetamide

1976 • 15 citations

High-performance liquid chromatographic profiles of low-molecular-weight, u.v.-absorbing compounds in the sera of beagles exposed to cigarette smoke

1981 • 10 citations

DNA damage, cell survival and DNA repair in Chinese hamster ovary cells after in vitro metabolic activation of dimethylnitrosamine and benzo[a]pyrene

1980 • 10 citations