DNA damage, cell survival and DNA repair in Chinese hamster ovary cells after in vitro metabolic activation of dimethylnitrosamine and benzo[a]pyrene

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine

1956 • 877 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

Reconstruction in vivo of Irradiated Escherichia coli Deoxyribonucleic Acid; the Rejoining of Broken Pieces

1966 • 727 citations

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

1964 • 687 citations

Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells.

1976 • 483 citations

Some chemical aspects of dose-response relationships in alkylation mutagenesis

1974 • 284 citations

Evidence for Repair of Ultra-Violet Damaged Deoxyribonucleic Acid in Cultured Mammalian Cells

1964 • 277 citations

Repair Processes for Photochemical Damage in Mammalian Cells

1974 • 245 citations

Mutagenic and carcinogenic N-nitroso compounds: Possible environmental hazards

1976 • 201 citations

The Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals

1978 • 173 citations

Mechanism of Alkylation of Nucleic Acids by Nitrosodimethylamine

1968 • 162 citations

In vitro DNA damage/alkaline elution assay for predicting carcinogenic potential

1976 • 150 citations

Liver homogenate-mediated mutagenesis in Chinese hamster V79 cells by polycyclic aromatic hydrocarbons and aflatoxins

1977 • 150 citations

Metabolism of benzo[a]pyrene

1975 • 148 citations

Mutability of different genetic loci in mammalian cells by metabolically activated carcinogenic polycyclic hydrocarbons.

1976 • 148 citations

Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA

1977 • 146 citations

Detection of DNA damage induced in vivo following exposure of rats to carcinogens.

1978 • 140 citations

Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.

1977 • 138 citations

Patterns of damage and repair of liver DNA induced by carcinogenic methylating agents in vivo.

1973 • 130 citations

Effect of DNA repair on the cytotoxicity and mutagenicity of polycyclic hydrocarbon derivatives in normal and xeroderma pigmentosum human fibroblasts

1977 • 109 citations

Metabolism of benzo(a)pyrene and identification of the major benzo(a)pyrene-DNA adducts in cultured human colon.

1978 • 107 citations

Microsome-mediated mutagenesis in V79 Chinese hamster cells by various nitrosamines.

1977 • 102 citations

Dual role of epoxide hydratase in both activation and inactivation of benzo(a)pyrene

1977 • 101 citations

The Effect of Oxygen on DNA Single-strand Breaks Produced by Ionizing Radiation in Mammalian Cells

1972 • 86 citations

Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool

1977 • 85 citations

Reduction of benzo(a)pyrene mutagenicity by dihydrodiol dehydrogenase

1979 • 83 citations

Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides.

1977 • 83 citations

The measurement of chemically-induced DNA repair synthesis in human cells by BND-Cellulose chromatography

1975 • 81 citations

Mutagenicity of isomeric diol-epoxides of benzo[a]pyrene and benz[a]anthracene in S. typhimurium TA98 and TA100 and in V79 Chinese hamster cells

1977 • 79 citations

DNA and RNA adducts formed in hamster embryo cell cultures exposed to benzo[a]pyrene

1978 • 78 citations

Sites in nucleic acids reacting with alkylating agents of differing carcinogenicity or mutagenicity

1977 • 77 citations

DNA Strand Scission by Benzo[ a ]pyrene Diol Epoxides

1977 • 75 citations

The nature of single-strand breaks in DNA following treatment of L-cells with methylating agents

1973 • 65 citations

In Vitro Repair of Apurinic Sites in DNA

1974 • 50 citations

Mutagenicity of dimethylnitrosamine to mammalian cells as determined by the use of mouse liver microsomes

1975 • 49 citations

Repair synthesis and sedimentation analysis of DNA of human cells exposed to dimethylnitrosamine and activated dimethylnitrosamine

1973 • 46 citations

Repair of DNA damage induced by benzo(a)pyrene diol-epoxides I and II in human alveolar tumor cells.

1978 • 44 citations

Phosphotriesters in rat liver deoxyribonucleic acid after the administration of the carcinogen NN-dimethylnitrosamine in vivo

1975 • 42 citations

Removal of methylated purines from rat liver DNA after administration of dimethylnitrosamine.

1978 • 40 citations

Methylation of DNA in rat liver and intestine by dimethylnitrosamine and N-methylnitrosourea

1977 • 37 citations

Repair of DNA damaged by mutagenic metabolites of benzo(a)pyrene in human cells

1978 • 34 citations

Use of high concentrations of dimethylnitrosamine in bacterial lethality, mutagenesis, and enzymological studies.

1978 • 28 citations

In vivo repair of rat liver DNA damaged by dimethylnitrosamine or diethylnitrosamine

1977 • 26 citations

Differences in patterns of structural change by rat liver DNA following administration of dimethylnitrosamine and methyl methanesulfonate.

1977 • 26 citations

The recovery of normal DNA replication kinetics in ultraviolet-irradiated Chinese hamster cells

1977 • 23 citations

Bromodeoxyuridine resistance induced in mouse lymphoma cells by microsomal activation of dimethylnitrosamine

1976 • 22 citations

The interaction of the 7,8-dihydrodiol-9, 10-oxides of benzo(a)pyrene with bacteriophages R17 and T7

1977 • 16 citations

Postreplication repair of DNA in human fibroblasts after UV irradiation or treatment with metabolites of benzo(a)pyrene

1978 • 15 citations