Error-free excision of the cytotoxic,mutagenic N2-deoxyguanosine DNA adduct formed in human fibroblasts by (+/-)-7 beta, 8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

Polycyclic Hydrocarbons and Cancer

1981 • 737 citations

Benzo[ a ]pyrene Diol Epoxides as Intermediates in Nucleic Acid Binding in Vitro and in Vivo

1976 • 584 citations

DNA excision-repair processes in human cells can eliminate the cytotoxic and mutagenic consequences of ultraviolet irradiation

1979 • 245 citations

Repair of Potentially Lethal Radiation DamageIn VitroandIn Vivo

1973 • 194 citations

Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids

1977 • 169 citations

Deficient recovery from potentially lethal radiation damage in ataxia telangiectasia and xeroderma pigmentosum

1978 • 159 citations

Identification of the major adducts formed by reaction of benzo(a)pyrene diol epoxide with DNA in vitro.

1977 • 138 citations

Repair of potentially lethal lesions in x-irradiated, density-inhibited Chinese hamster cells: metabolic effects and hypoxia.

1973 • 86 citations

The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moieties

1978 • 72 citations

Development of a liquid-holding technique for the study of DNA-repair in human diploid fibroblasts

1979 • 70 citations

Formation of DNA adducts in 10T1/2 mouse embryo fibroblasts incubated with benzo(a)pyrene or dihydrodiol oxide derivatives.

1979 • 70 citations

Correlation among the rates of dimer excision, DNA repair replication, and recovery of human cells from potentially lethal damage induced by ultraviolet radiation

1979 • 62 citations

The nature of benzo(a)pyrene-DNA adducts formed in hamster embryo cells depends on the length of time of exposure to benzo(a)pyrene

1977 • 55 citations

A comparison of the DNA binding, cytotoxicity and repair synthesis induced in human fibroblasts by reactive derivatives of aromatic amide carcinogens

1980 • 52 citations

Reactive derivatives of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene cause S1 nuclease sensitive sites in DNA and “uv-like” repair

1977 • 45 citations

Excision repair by human fibroblasts of DNA damaged by r-7, t-8-dihydroxy-t-9,10-OXY-7,8,9,10-tetrahydrobenzo(a)pyrene

1978 • 44 citations

Modification of DNA by the benzo[a]pyrene metabolite diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

1978 • 41 citations

Formation and excision of covalent deoxyribonucleic acid adducts of benzo[a]pyrene 4,5-epoxide and benzo[a]pyrenediol epoxide I in human lung cells A549

1980 • 38 citations